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Respiratory Research
Published in: Respiratory Research 6/2001

Open Access 01-12-2001 | Review

The role of collagenase in emphysema

Authors: Robert Foronjy, Jeanine D'Armiento

Published in: Respiratory Research | Issue 6/2001

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Abstract

The extracellular matrix is essential for the integrity of the lung and when disrupted can lead to the architectural changes seen in emphysema. The etiology of emphysema is believed to be due to an imbalance in the proteases and antiproteases within the lung. Studies have focused on elastolytic enzymes as the primary agents in disease pathogenesis, however, recent data suggest that collagenases may also be involved in the destruction of lung tissue in emphysema. It is hoped that this expanded understanding of the pathophysiology of emphysema will lead to improved therapy in the treatment of the disease.
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Metadata
Title
The role of collagenase in emphysema
Authors
Robert Foronjy
Jeanine D'Armiento
Publication date
01-12-2001
Publisher
BioMed Central
Published in
Respiratory Research / Issue 6/2001
Electronic ISSN: 1465-993X
DOI
https://doi.org/10.1186/rr85

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