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Annals of General Psychiatry
Published in: Annals of General Psychiatry 1/2015

Open Access 01-12-2015 | Review

The role of cognitive dysfunction in the symptoms and remission from depression

Authors: Xenia Gonda, Maurizio Pompili, Gianluca Serafini, Andre F. Carvalho, Zoltan Rihmer, Peter Dome

Published in: Annals of General Psychiatry | Issue 1/2015

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Abstract

The disability and burden associated with major depression comes only in part from its affective symptoms; cognitive dysfunctions associated with depression also play a crucial role. Furthermore, these cognitive impairments during depression are manifold and multilevel affecting elementary and more complex cognitive processes equally. Several models from different directions tried to evaluate, conceptualize and understand the depth and magnitude of cognitive dysfunctions in depression and their bidirectional interactions with other types of depressive symptomatology including mood symptoms. In the current review, we briefly overview different types of cognitive symptoms and deficits related to major depression including hot and cold as well as trait- and state-like cognitive alterations and we also describe current knowledge related to the impact of cognitive impairments on the course and outcomes of depression including remission, residual symptoms, function, and response to treatment. We also emphasize shortcomings of currently available treatments for depression in sufficiently improving cognitive dysfunctions and point out the need for newer pharmacological approaches especially in cooperation with psychotherapeutic interventions.
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Metadata
Title
The role of cognitive dysfunction in the symptoms and remission from depression
Authors
Xenia Gonda
Maurizio Pompili
Gianluca Serafini
Andre F. Carvalho
Zoltan Rihmer
Peter Dome
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Annals of General Psychiatry / Issue 1/2015
Electronic ISSN: 1744-859X
DOI
https://doi.org/10.1186/s12991-015-0068-9

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