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International Orthopaedics
Published in: International Orthopaedics 7/2018

01-07-2018 | Review Article

The role of autophagy in steroid necrosis of the femoral head: a comprehensive research review

Authors: Pan Luo, Fuqiang Gao, Jun Han, Wei Sun, Zirong Li

Published in: International Orthopaedics | Issue 7/2018

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Abstract

Steroid-induced osteonecrosis of the femoral head (ONFH) has the incidence of 9–40% in patients receiving long-term treatment and is mainly involved in the middle and young people. It is mostly bilateral, with a wide range of necrosis and high disability rate, which brings disaster for patients and families. The experimental study shows that autophagy participates in the pathological process of steroid ONFH and is closely related to apoptosis, and the interaction between autophagy and bone cells is related to the dose of hormones. Moreover, autophagy also affects the interaction between osteoblasts and osteoclasts in ONFH. In the present review, we have discussed the role of autophagy in the pathological process of the steroid-induced ONFH.
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Metadata
Title
The role of autophagy in steroid necrosis of the femoral head: a comprehensive research review
Authors
Pan Luo
Fuqiang Gao
Jun Han
Wei Sun
Zirong Li
Publication date
01-07-2018
Publisher
Springer Berlin Heidelberg
Published in
International Orthopaedics / Issue 7/2018
Print ISSN: 0341-2695
Electronic ISSN: 1432-5195
DOI
https://doi.org/10.1007/s00264-018-3994-8

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