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Magnetic Resonance Materials in Physics, Biology and Medicine

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01-04-2012 | Research Article

The response to rapid infusion of fentanyl in the human brain measured using pulsed arterial spin labelling

Authors: Fernando O. Zelaya, Evangelos Zois, Christopher Muller-Pollard, David J. Lythgoe, Sarah Lee, Caroline Andrews, Trevor Smart, Patricia Conrod, William Vennart, Steven C. R. Williams, Mitul A. Mehta, Laurence J. Reed

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 2/2012

Abstract

Objective

We evaluated the sensitivity of pulsed Arterial Spin Labelling (pASL) for the detection of changes in regional cerebral blood perfusion (CBP) during and after intra-venous (i.v.) infusion of an opioid agonist (fentanyl) and an opioid antagonist (naloxone).

Materials and methods

Twenty-three subjects were scanned four times, receiving i.v. infusion of fentanyl, naloxone, placebo and a second fentanyl administration, in four separate scanning sessions in randomised order. End-tidal CO₂, respiration rate and heart rate were recorded continuously throughout each scan. pASL time series were collected using single shot EPI for 15 min (including 5 min of baseline prior to infusion).

Results

Significant increases in CBP were detected during and after administration of fentanyl, (when compared to placebo and naloxone), in most areas of high concentration of mu-opioid receptors (thalamus, lingual gyrus, para-hippocampal gyrus, and insula); near-significant increases were also observed in the insula. No increases in perfusion were observed during or after naloxone infusion. No correlation was found between regional rCBF changes and end-tidal CO₂, respiration rate or heart rate. Good reliability was found between the first and second fentanyl sessions but the regions of high reliability did not overlap completely with those of highest perfusion change.

Conclusion

pASL is a suitable method for examining rapid, dynamic effects of opioid administration on brain physiology.

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Title: The response to rapid infusion of fentanyl in the human brain measured using pulsed arterial spin labelling
Authors: Fernando O. Zelaya
Evangelos Zois
Christopher Muller-Pollard
David J. Lythgoe
Sarah Lee
Caroline Andrews
Trevor Smart
Patricia Conrod
William Vennart
Steven C. R. Williams
Mitul A. Mehta
Laurence J. Reed
Publication date: 01-04-2012
Publisher: Springer-Verlag
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 2/2012
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-011-0293-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The response to rapid infusion of fentanyl in the human brain measured using pulsed arterial spin labelling

Abstract

Objective

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Materials and methods

Results

Conclusion

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