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Health and Quality of Life Outcomes
Published in: Health and Quality of Life Outcomes 1/2011

Open Access 01-12-2011 | Research

The relative impact of vision impairment and cardiovascular disease on quality of life: the example of pseudoxanthoma elasticum

Authors: Robert P Finger, Eva Fenwick, Manjula Marella, Peter Charbel Issa, Hendrik PN Scholl, Frank G Holz, Ecosse L Lamoureux

Published in: Health and Quality of Life Outcomes | Issue 1/2011

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Abstract

Objective

To investigate the impact of pseudoxanthoma elasticum (PXE), a rare hereditary disease of concurrent vision impairment (VI) and cardiovascular complications (CVCs), on vision-related (VRQoL) and health-related quality of life (HRQoL).

Methods

VRQoL and HRQoL were assessed using the Impact of Vision Impairment (IVI) questionnaire and the Short Form Health Survey (SF-36) in 107 PXE patients. Patients were stratified into four groups: A = no VI or CVC; B = CVCs only; C = VI only; and D = both VI and CVCs.

Results

Following Rasch analysis, the IVI was found to function as a vision-specific functioning and emotional well-being subscale, and the SF-36 as a health-related physical functioning and mental health subscale. The presence of VI and CVC were significant predictors of vision-specific functioning and emotional well-being (p < 0.001), with a clinically meaningful decrement in vision-specific functioning in patients with VI. No associations were found for the SF-36 Physical Functioning and Mental Health scores between any groups.

Conclusions

Vision impaired patients with PXE report significantly poorer vision-specific functioning than PXE patients without VI. In contrast, the relative impact of PXE on reported general HRQoL was much less. Our results suggest that vision impairment has the larger impact on QoL in this sample.
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Metadata
Title
The relative impact of vision impairment and cardiovascular disease on quality of life: the example of pseudoxanthoma elasticum
Authors
Robert P Finger
Eva Fenwick
Manjula Marella
Peter Charbel Issa
Hendrik PN Scholl
Frank G Holz
Ecosse L Lamoureux
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Health and Quality of Life Outcomes / Issue 1/2011
Electronic ISSN: 1477-7525
DOI
https://doi.org/10.1186/1477-7525-9-113

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