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01-04-2016 | Original Article

The relationship between smoking and quality of life in advanced lung cancer patients: a prospective longitudinal study

Authors: Sarah J. Danson, Christine Rowland, Richard Rowe, Sue Ellis, Carol Crabtree, Janet M. Horsman, Jonathan Wadsley, Matthew Q. Hatton, Penella J. Woll, Christine Eiser

Published in: Supportive Care in Cancer | Issue 4/2016

Abstract

Purpose

Smoking is a major cause of lung cancer, and continued smoking may compromise treatment efficacy and quality of life (health-related quality of life (HRQoL)) in patients with advanced lung cancer. Our aims were to determine (i) preference for treatments which promote quality over length of life depending on smoking status, (ii) the relationship between HRQoL and smoking status at diagnosis (T1), after controlling for demographic and clinical variables, and (iii) changes in HRQoL 6 months after diagnosis (T2) depending on smoking status.

Methods

Two hundred ninety-six patients with advanced lung cancer were given questionnaires to assess HRQoL (EORTC QLQ-C30), time-trade-off for life quality versus quantity (QQQ) and smoking history (current, former or never smoker) at diagnosis (T1) and 6 months later (T2). Medical data were extracted from case records.

Results

Questionnaires were returned by 202 (68.2 %) patients at T1 and 114 (53.3 %) at T2. Patients favoured treatments that would enhance quality of life over increased longevity. Those who continued smoking after diagnosis reported worse HRQoL than former smokers or those who never smoked. Smoking status was a significant independent predictor of coughing in T1 (worse in smokers) and cognitive functioning in T2 (better in never smokers).

Conclusions

Smoking by patients with advanced lung cancer is associated with worse symptoms on diagnosis and poorer HRQoL for those who continue smoking. The results have implications to help staff explain the consequences of smoking to patients.

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Title: The relationship between smoking and quality of life in advanced lung cancer patients: a prospective longitudinal study
Authors: Sarah J. Danson
Christine Rowland
Richard Rowe
Sue Ellis
Carol Crabtree
Janet M. Horsman
Jonathan Wadsley
Matthew Q. Hatton
Penella J. Woll
Christine Eiser
Publication date: 01-04-2016
Publisher: Springer Berlin Heidelberg
Published in: Supportive Care in Cancer / Issue 4/2016
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-015-2928-x

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