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BMC Public Health
Published in: BMC Public Health 1/2009

Open Access 01-12-2009 | Research article

The relation of metabolic syndrome according to five definitions to cardiovascular risk factors - a population-based study

Authors: Cheng-Chieh Lin, Chiu-Shong Liu, Chia-Ing Li, Wen-Yuan Lin, Ming-May Lai, Tsann Lin, Pei-Chia Chang, Yih-Dar Lee, Ching-Chu Chen, Chih-Hsueh Lin, Chuan-Wei Yang, Chih-Yi Hsiao, Walter Chen, Tsai-Chung Li

Published in: BMC Public Health | Issue 1/2009

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Abstract

Background

Although National Cholesterol Education Program (NCEP), International Diabetes Federation (IDF), American Heart Association and National Heart, Lung and Blood Institute (AHA/NHLBI), World Health Organization (WHO), and the European Group for the Study of Insulin Resistance (EGIR) definitions of metabolic syndrome (MetS) have been commonly used by studies, little is known about agreement among these five definitions. We examined the agreement among these five definitions and explored their relationship with risk factors of cardiovascular disease in a Taiwan population.

Methods

A total of 1305 subjects aged 40 years and over in Taiwan were analyzed. Biomedical markers and anthropometric indices were measured. Agreement among definitions was determined by the kappa statistic. Logistic regression models were fit to estimate the odds of a high cardiovascular risk group for five definitions of MetS.

Results

The agreement among the NCEP, IDF, and AHA/NHLBI definitions was from substantial to very good, and agreement between the WHO and EGIR definitions was also substantial. All MetS definitions were significantly associated prevalence of microalbuminuria, elevated highly sensitive CRP (hs-CRP), and arterial stiffness only in women. In men, MetS by NCEP and AHA/NHLBI was associated with elevated level of hs-CRP and arterial stiffness. MetS by WHO and EGIR were significantly associated with microalbuminuria. And MetS by WHO was the only MetS definition that significantly associated with prevalence of arterial stiffness (OR: 2.75, 95% CI: 1.22-6.19).

Conclusions

The associations of these five definitions with cardiovascular risk factors were similar in women, and it was evident that the five definitions performed better in women than in men, with higher ORs observed in relation to arterial stiffness, elevated hs-CRP, and higher Framingham risk scores.
Appendix
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Metadata
Title
The relation of metabolic syndrome according to five definitions to cardiovascular risk factors - a population-based study
Authors
Cheng-Chieh Lin
Chiu-Shong Liu
Chia-Ing Li
Wen-Yuan Lin
Ming-May Lai
Tsann Lin
Pei-Chia Chang
Yih-Dar Lee
Ching-Chu Chen
Chih-Hsueh Lin
Chuan-Wei Yang
Chih-Yi Hsiao
Walter Chen
Tsai-Chung Li
Publication date
01-12-2009
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2009
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/1471-2458-9-484

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