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Dermatology and Therapy

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Open Access 07-03-2024 | Original Research

The Real-World Effectiveness and Tolerability of a Soothing Cream Containing the Postbiotic Aquaphilus dolomiae Extract-G2 for Skin Healing

Authors: Yuling Shi, Edward Lain, Nicolas Frasson, Ariadna Ortiz-Brugués, Aline Stennevin

Published in: Dermatology and Therapy | Issue 3/2024

Abstract

Introduction

In vitro and pre-marketing clinical data have shown the healing properties of a postbiotic extract from Aquaphilus dolomiae (ADE-G2). The effectiveness and tolerability of an ADE-G2-based cream were therefore evaluated for the management of minor skin impairment and wound healing in a large population of subjects in routine clinical practice.

Methods

A real-world, international, pre-post comparative study was conducted in infants, children, and adults with various types of superficial skin impairment who used the study product daily for around 3 weeks according to their dermatologist’s advice. Immediate and follow-up changes in dermatologic signs and symptoms were assessed through clinical scoring. User satisfaction, overall product effectiveness, and tolerability were also evaluated. Analyses were performed in the whole study population and in subject subgroups according to skin impairment type and age.

Results

Overall, 1317 subjects (83.1% adults, 72.0% female) were included. Dermatologists reported effectiveness and “good” or “very good” tolerability of the cream in 93.8% (1221/1302) and 98.5% (1278/1297) of subjects, respectively. Immediate symptom relief after the first application was reported by 88.3% (849/962) of subjects. After several weeks of regular use (16.7 ± 11.6 days), dermatologic signs and symptoms significantly improved in the whole study population and in the subgroups, with mean decreases in severity scores ranging from –34.5% to –92.5% (p < 0.0001). The smallest improvements were found in subjects with oncologic treatment-related skin impairment. At study end, most users (> 95%) were “very satisfied” or “satisfied” with the cream and found that skin healing was rapid and of good quality.

Conclusion

The ADE-G2-based cream proved to be effective and well tolerated in real-life conditions for the management of minor skin impairment in a large and varied cohort of subjects. This product, used as a standalone or adjunctive regimen, can help accelerate the healing of various types of superficial skin impairment.

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Title: The Real-World Effectiveness and Tolerability of a Soothing Cream Containing the Postbiotic Aquaphilus dolomiae Extract-G2 for Skin Healing
Authors: Yuling Shi
Edward Lain
Nicolas Frasson
Ariadna Ortiz-Brugués
Aline Stennevin
Publication date: 07-03-2024
Publisher: Springer Healthcare
Published in: Dermatology and Therapy / Issue 3/2024
Print ISSN: 2193-8210
Electronic ISSN: 2190-9172
DOI: https://doi.org/10.1007/s13555-024-01119-x

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