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European Archives of Oto-Rhino-Laryngology
Published in: European Archives of Oto-Rhino-Laryngology 4/2016

01-04-2016 | Review Article

The prognostic value of cyclin D1 expression in head and neck squamous cell carcinoma

Authors: Federico M. Gioacchini, Matteo Alicandri-Ciufelli, Shaniko Kaleci, Giuseppe Magliulo, Livio Presutti, Massimo Re

Published in: European Archives of Oto-Rhino-Laryngology | Issue 4/2016

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Abstract

The correlation between cyclin D1 overexpression and the clinical outcome of head and neck cancer is not defined. The aim of this meta-analysis was to evaluate the prognostic value of cyclin D1 in patients with head and neck cancer. A search thorough Ovid MEDLINE was performed to enroll all eligible articles. Twenty-two studies comprising a total of 1,929 patients with different head and neck cancers were included. Cyclin D1 overexpression was significantly associated with lymph node metastasis [OR 2.25; 95 % confidence interval (CI) 1.76–2.87] and worse disease-free survival (OR 3.06; 95 % CI 2.42–3.87]. Subgroup analysis revealed that cyclin D1 overexpression correlated significantly with nodal metastasis for laryngeal cancer (OR 2.26; 95 % CI 1.61–3.16) and was a significant poor predictor for nasopharyngeal cancer (OR 4.44; 95 % CI 1.89–10.42). Our meta-analysis suggests that cyclin D1 overexpression could represent an important prognostic indicator for patients with head and neck cancer.
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Metadata
Title
The prognostic value of cyclin D1 expression in head and neck squamous cell carcinoma
Authors
Federico M. Gioacchini
Matteo Alicandri-Ciufelli
Shaniko Kaleci
Giuseppe Magliulo
Livio Presutti
Massimo Re
Publication date
01-04-2016
Publisher
Springer Berlin Heidelberg
Published in
European Archives of Oto-Rhino-Laryngology / Issue 4/2016
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-014-3426-3

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