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01-06-2016 | Original Article

The prognostic impact of squamous and glandular differentiation for upper tract urothelial carcinoma patients after radical nephroureterectomy

Authors: Qi Tang, Gengyan Xiong, Xuesong Li, Dong Fang, Chenguang Xi, Lei Zhang, Kaiwei Yang, Lin Yao, Cuijian Zhang, Wei Yu, Qun He, Kan Gong, Zhisong He, Liqun Zhou

Published in: World Journal of Urology | Issue 6/2016

Abstract

Purpose

To evaluate the association between tumor squamous and/or glandular differentiation and tumor biological characteristics and to validate the impact of these histologic variants on oncologic outcomes of UTUC patients.

Methods

We retrospectively analyzed the data of 687 UTUC patients who underwent radical nephroureterectomy in our institute, from Aug 1, 1999, to Dec 31, 2011. All pathologic sections were reevaluated for histologic differentiation variations (squamous and glandular). The clinicopathological variables of patients were reviewed.

Results

Among the 687 UTUC patients in our study, 53 (7.7 %) had squamous differentiation, 20 (2.9 %) had glandular differentiation and 8 (1.2 %) had both histologic variants. Patients with mixed histologic variant tended to have significant larger percentage of sessile tumor architecture (58.0 vs 18.2 %), presence of CIS (7.4 vs 2.3 %), advanced T stage, advanced tumor grade and lymph node metastasis (17.3 vs 6.6 %; all p < 0.05). Patients with squamous and/or glandular differentiation had significant worse cancer-specific survival than pure UTUC patients (p < 0.001), while significant difference of recurrence-free survival between two groups was not observed (p = 0.126). Patients with both squamous and glandular differentiation did not show significantly worse CSS than those with single histologic variant. Univariate analyses revealed that tumor squamous and/or glandular differentiation was a significant factor on survival (p < 0.001). However, the influence did not remain significant after adjusted for other factors in the multivariate analyses (p = 0.076, HR 1.42).

Conclusions

UTUC patients with squamous and/or glandular differentiation are more likely to have aggressive tumor biological features and tend to have worse postoperative outcomes.

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Title: The prognostic impact of squamous and glandular differentiation for upper tract urothelial carcinoma patients after radical nephroureterectomy
Authors: Qi Tang
Gengyan Xiong
Xuesong Li
Dong Fang
Chenguang Xi
Lei Zhang
Kaiwei Yang
Lin Yao
Cuijian Zhang
Wei Yu
Qun He
Kan Gong
Zhisong He
Liqun Zhou
Publication date: 01-06-2016
Publisher: Springer Berlin Heidelberg
Published in: World Journal of Urology / Issue 6/2016
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-015-1715-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The prognostic impact of squamous and glandular differentiation for upper tract urothelial carcinoma patients after radical nephroureterectomy

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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SIU Newsletter - June 2016