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01-04-2018 | Original Scientific Report

The Prognostic Impact of Controlling Nutritional Status (CONUT) in Intrahepatic Cholangiocarcinoma Following Curative Hepatectomy: A Retrospective Single Institution Study

Authors: Tatsunori Miyata, Yo-ichi Yamashita, Takaaki Higashi, Katsunobu Taki, Daisuke Izumi, Keisuke Kosumi, Ryuma Tokunaga, Shigeki Nakagawa, Hirohisa Okabe, Katsunori Imai, Daisuke Hashimoto, Akira Chikamoto, Hideo Baba

Published in: World Journal of Surgery | Issue 4/2018

Abstract

Background

Several studies have examined controlling nutritional status (CONUT), which is one of the useful biomarkers for predicting patients’ prognosis following cancer treatment. The aim of this study was to evaluate the value of CONUT as a postoperative prognostic marker in patients with intrahepatic cholangiocarcinoma (ICC) following curative hepatectomy.

Methods

We retrospectively analyzed 71 patients who underwent curative hepatectomy for ICC between May 2002 and November 2016. Patients were divided into two groups according to their preoperative CONUT score (i.e., CONUT ≧ 2 or CONUT < 2).

Results

The number of patients assigned to the normal, mild, moderate, or severe malnutrition groups was 40, 28, two, and one, respectively. The high CONUT group (CONUT ≧ 2) consisted of 31 patients (43.7%) and had a poor prognosis with regard to overall survival (OS) (p = 0.0149). A high CONUT score is also identified as one of the independent predictors of poor prognosis in OS (hazard ratio 3.02; 95% confidence interval 1.4–6.8; p = 0.007). However, in the current study, a high CONUT score was not associated with postoperative complications (Clavien–Dindo classification ≧ III or more).

Conclusions

CONUT may be useful for the preoperative assessment of prognosis in patients with ICC who have undergone curative hepatectomy.

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Title: The Prognostic Impact of Controlling Nutritional Status (CONUT) in Intrahepatic Cholangiocarcinoma Following Curative Hepatectomy: A Retrospective Single Institution Study
Authors: Tatsunori Miyata
Yo-ichi Yamashita
Takaaki Higashi
Katsunobu Taki
Daisuke Izumi
Keisuke Kosumi
Ryuma Tokunaga
Shigeki Nakagawa
Hirohisa Okabe
Katsunori Imai
Daisuke Hashimoto
Akira Chikamoto
Hideo Baba
Publication date: 01-04-2018
Publisher: Springer International Publishing
Published in: World Journal of Surgery / Issue 4/2018
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-017-4214-1

At a glance: The STEP trials

Springer Medicine

The Prognostic Impact of Controlling Nutritional Status (CONUT) in Intrahepatic Cholangiocarcinoma Following Curative Hepatectomy: A Retrospective Single Institution Study

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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