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Published in:

01-10-2011

The Potential Role of Interleukin-17 in Severe Asthma

Authors: Yui-Hsi Wang, Marsha Wills-Karp

Published in: Current Allergy and Asthma Reports | Issue 5/2011

Abstract

Asthma has long been characterized as a disease of dysregulated T-helper type 2 immune responses to environmental allergens. Clinical studies suggest that asthma is a heterogeneous disorder with distinct types of inflammatory processes. Accumulating evidence suggests that aberrant interleukin (IL)-17 production is a key determinant of severe forms of asthma. However, the identity of IL-17–producing cells and the factors regulating IL-17 production during the course of allergic inflammation remain elusive. In this review, we summarize the potential IL-17–producing cells and their involvement in the inflammatory responses that mediate distinct features of asthma. The role of proinflammatory cytokines and the complement pathway in regulating the generation of IL-17–producing T cells is also discussed. Understanding the biology of IL-17 in the context of allergic inflammation may be informative in the development of novel approaches to the diagnosis and treatment of asthma.

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Title: The Potential Role of Interleukin-17 in Severe Asthma
Authors: Yui-Hsi Wang
Marsha Wills-Karp
Publication date: 01-10-2011
Publisher: Current Science Inc.
Published in: Current Allergy and Asthma Reports / Issue 5/2011
Print ISSN: 1529-7322
Electronic ISSN: 1534-6315
DOI: https://doi.org/10.1007/s11882-011-0210-y

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The Potential Role of Interleukin-17 in Severe Asthma

Abstract

Keynote webinar | Spotlight on medication adherence

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Abstract

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