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Open Access 01-06-2013 | Original Article

The polymorphisms of the MMP-1 and the MMP-3 genes and the risk of pelvic organ prolapse

Authors: Paweł Skorupski, Katarzyna Jankiewicz, Paweł Miotła, Małgorzata Marczak, Beata Kulik-Rechberger, Tomasz Rechberger

Published in: International Urogynecology Journal | Issue 6/2013

Abstract

Introduction and hypothesis

To investigate the associations between single nucleotide polymorphism (SNP) type 1G/2G at position −1607/−1608 of the matrix metalloproteinase (MMP)-1 gene and SNP type 5A/6A at position −1612/-1617 of the MMP-3 gene and the development of pelvic organ prolapse (POP) in women.

Methods

133 patients with symptomatic POP were included in the study group. The control group consisted of 132 women with a normal pelvic floor. 1G/2G MMP-1 and 5A/6A MMP-3 SNPs were determined by polymerase chain reaction (PCR) and restriction fragments length polymorphism analysis.

Results

When estimated individually none of the investigated SNPs were associated with POP. The combined MMP-1/MMP-3 SNP analysis showed that the following polymorphic pairs were overrepresented in women with POP: 1G/2G −5A/6A, 2G/2G −5A/6A, 2G/2G −5A/5A, 1G/1G −6A/6A, p = 0.005.

Conclusions

The combined effect of −1607/−1608 MMP-1 and −1612/−1617 MMP-3 SNPs may contribute to the development of POP in some women.

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Title: The polymorphisms of the MMP-1 and the MMP-3 genes and the risk of pelvic organ prolapse
Authors: Paweł Skorupski
Katarzyna Jankiewicz
Paweł Miotła
Małgorzata Marczak
Beata Kulik-Rechberger
Tomasz Rechberger
Publication date: 01-06-2013
Publisher: Springer-Verlag
Published in: International Urogynecology Journal / Issue 6/2013
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-012-1970-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The polymorphisms of the MMP-1 and the MMP-3 genes and the risk of pelvic organ prolapse

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

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