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Published in: Sports Medicine 6/2012

01-06-2012 | Review Article

The Oxygen Uptake Response to Incremental Ramp Exercise

Methodogical and Physiological Issues

Authors: Mr Jan Boone, Jan Bourgois

Published in: Sports Medicine | Issue 6/2012

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Abstract

An incremental ramp exercise is a protocol that is frequently used in the domain of exercise testing to get an insight into the exercise tolerance of both healthy active populations (including athletes) and patients, due to the specific characteristics of the protocol. The continuous and linear increase in work rate is not only less strenuous for populations with a very low exercise capacity but it requires the aerobic metabolism to adapt to the continuously changing conditions. Therefore, this protocol can provide important information on the adaptive capacity of individuals to exercise in non-steady-state conditions. The ramp exercise has also been used in the past two decades to get an insight into the underlying mechanisms of the oxygen uptake (\(\dot V\)O2) response (and kinetics) to exercise. Against the expectations, it has been shown that the parameters that quantify the \(\dot V\)O2 response to ramp exercise do not completely correspond to those obtained from constant work-rate transitions and incremental step exercise. For that reason, it could be concluded that the \(\dot V\)O2 response is specific to ramp exercise, and thus is determined by other mechanisms than those which determine other protocols. Although the \(\dot V\)O2 response to ramp exercise has a high level of reproducibility and a uniform pattern can be observed, especially for the \(\dot V\)O2 response below the gas exchange threshold (GET) [above the GET, the \(\dot V\)O2 response is less clear, some prudence is necessary when interpreting potential differences in the \(\dot V\)O2 response between populations. Several methodological issues (e.g. baseline work rate, ramp slope) exert an important impact on the \(\dot V\)O2 response to ramp exercise. The main purpose of this review is to provide an overview of the methodological and physiological factors that have an impact on the \(\dot V\)O2 response to ramp exercise. It is of importance that exercise physiologists take these factors into consideration, not only prior to the conductance of the ramp exercise in a variety of subjects, but also when interpreting the obtained results.
Literature
1.
go back to reference Krogh A, Lindhard J. The regulation of respiration and circulation during the initial stages of muscular work. J Physiol (London) 1913; 47: 112–36 Krogh A, Lindhard J. The regulation of respiration and circulation during the initial stages of muscular work. J Physiol (London) 1913; 47: 112–36
2.
go back to reference Henry FM. Aerobic oxygen consumption and alactic debt in muscular work. J Appl Physiol 1951; 3: 427–38PubMed Henry FM. Aerobic oxygen consumption and alactic debt in muscular work. J Appl Physiol 1951; 3: 427–38PubMed
3.
go back to reference Linnarsson D. Dynamics of pulmonary gas exchange and heart rate changes at start and end of exercise. Acta Physiol Scand Suppl 1974; 415: 1–68PubMed Linnarsson D. Dynamics of pulmonary gas exchange and heart rate changes at start and end of exercise. Acta Physiol Scand Suppl 1974; 415: 1–68PubMed
4.
go back to reference Whipp BJ, Ward SA, Lamarra N, et al. Parameters of ventilatory and gas exchange dynamics during exercise. J Appl Physiol 1982; 52: 1506–13PubMed Whipp BJ, Ward SA, Lamarra N, et al. Parameters of ventilatory and gas exchange dynamics during exercise. J Appl Physiol 1982; 52: 1506–13PubMed
5.
go back to reference Whipp BJ, Wasserman K. Oxygen uptake kinetics for various intensities of constant-load work. J Appl Physiol 1972; 33: 351–6PubMed Whipp BJ, Wasserman K. Oxygen uptake kinetics for various intensities of constant-load work. J Appl Physiol 1972; 33: 351–6PubMed
6.
go back to reference Buchfuhrer MJ, Hansen JE, Robinson TE, et al. Optimizing the exercise protocol for cardiopulmonary assessment. J Appl Physiol 1983; 55: 1558–64PubMed Buchfuhrer MJ, Hansen JE, Robinson TE, et al. Optimizing the exercise protocol for cardiopulmonary assessment. J Appl Physiol 1983; 55: 1558–64PubMed
7.
go back to reference Boone J, Koppo K, Bouckaert J. The \(\dot V\)O2 response to submaximal ramp cycle exercise: influence of ramp slope and training status. Respir Physiol Neurobiol 2008; 161: 291–7PubMedCrossRef Boone J, Koppo K, Bouckaert J. The \(\dot V\)O2 response to submaximal ramp cycle exercise: influence of ramp slope and training status. Respir Physiol Neurobiol 2008; 161: 291–7PubMedCrossRef
8.
go back to reference Jones AM, Campbell IT, Pringle JS. Influence of muscle fibre type and pedal rate on the \(\dot V\)O2 -work rate slope during ramp exercise. Eur J Appl Physiol 2004; 91: 238–45PubMedCrossRef Jones AM, Campbell IT, Pringle JS. Influence of muscle fibre type and pedal rate on the \(\dot V\)O2 -work rate slope during ramp exercise. Eur J Appl Physiol 2004; 91: 238–45PubMedCrossRef
9.
go back to reference Whipp BJ, Davis JA, Torres F, et al. A test to determine parameters of aerobic function during exercise. J Appl Physiol 1981; 50: 217–21PubMed Whipp BJ, Davis JA, Torres F, et al. A test to determine parameters of aerobic function during exercise. J Appl Physiol 1981; 50: 217–21PubMed
10.
go back to reference Stegemann J. Beitrag zum dynamik der atmungs-regelung bei leichter muskelarbeit. Z Biol 1958; 110: 449–56PubMed Stegemann J. Beitrag zum dynamik der atmungs-regelung bei leichter muskelarbeit. Z Biol 1958; 110: 449–56PubMed
11.
go back to reference Whipp BJ, Mahler M. Dynamics of gas exchange during exercise. In: West JB, editor. Pulmonary gas exchange. Vol. II. New York: Academic Press, 1980: 33–96 Whipp BJ, Mahler M. Dynamics of gas exchange during exercise. In: West JB, editor. Pulmonary gas exchange. Vol. II. New York: Academic Press, 1980: 33–96
12.
go back to reference Wigertz O. Dynamics of ventilation and heart rate in response to sinusoidal work in man. J Appl Physiol 1970; 29: 208–18PubMed Wigertz O. Dynamics of ventilation and heart rate in response to sinusoidal work in man. J Appl Physiol 1970; 29: 208–18PubMed
13.
go back to reference Barstow TJ, Molé PA. Linear and nonlinear characteristics of oxygen uptake kinetics during heavy exercise. J Appl Physiol 1991; 71: 2099–106PubMed Barstow TJ, Molé PA. Linear and nonlinear characteristics of oxygen uptake kinetics during heavy exercise. J Appl Physiol 1991; 71: 2099–106PubMed
14.
go back to reference Trappe S, Harber M, Creer A, et al. Single muscle fibre adaptations with marathon training. J Appl Physiol 2006; 101:721–7PubMedCrossRef Trappe S, Harber M, Creer A, et al. Single muscle fibre adaptations with marathon training. J Appl Physiol 2006; 101:721–7PubMedCrossRef
15.
go back to reference Davis JA, Whipp BJ, Lamarra N, et al. Effect of ramp slope on determination of aerobic parameters from the ramp exercise test. Med Sci Sports Exerc 1982; 14: 339–43PubMed Davis JA, Whipp BJ, Lamarra N, et al. Effect of ramp slope on determination of aerobic parameters from the ramp exercise test. Med Sci Sports Exerc 1982; 14: 339–43PubMed
16.
go back to reference Swanson GD, Hughson RL. On the modelling and interpretation of oxygen uptake kinetics from ramp work rate tests. J Appl Physiol 1988; 65: 2453–8PubMed Swanson GD, Hughson RL. On the modelling and interpretation of oxygen uptake kinetics from ramp work rate tests. J Appl Physiol 1988; 65: 2453–8PubMed
17.
go back to reference Markovitz GH, Sayre JW, Storer TW, et al. On the issues of confidence in determining the time constant for oxygen uptake kinetics. Brit J Sports Med 2003; 38: 553–60CrossRef Markovitz GH, Sayre JW, Storer TW, et al. On the issues of confidence in determining the time constant for oxygen uptake kinetics. Brit J Sports Med 2003; 38: 553–60CrossRef
18.
go back to reference Meyer K, Schwaibold M, Hajric R, et al. Delayed \(\dot V\)O2 kinetics during ramp exercise: a criterion for cardiopulmonary exercise capacity in chronic heart failure. Med Sci Sports Exerc 1998; 30: 643–8PubMedCrossRef Meyer K, Schwaibold M, Hajric R, et al. Delayed \(\dot V\)O2 kinetics during ramp exercise: a criterion for cardiopulmonary exercise capacity in chronic heart failure. Med Sci Sports Exerc 1998; 30: 643–8PubMedCrossRef
19.
go back to reference Beaver WL, Wasserman K, Whipp BJ. A new method for detecting anaerobic threshold by gas exchange. J Appl Physiol 1986; 60: 2020–7PubMed Beaver WL, Wasserman K, Whipp BJ. A new method for detecting anaerobic threshold by gas exchange. J Appl Physiol 1986; 60: 2020–7PubMed
20.
go back to reference Coyle EF, Sidossis LS, Horowitz JF, et al. Cycling efficiency is related to the percentage of type I muscle fibres. Med Sci Sports Exerc 1992; 24: 782–8PubMed Coyle EF, Sidossis LS, Horowitz JF, et al. Cycling efficiency is related to the percentage of type I muscle fibres. Med Sci Sports Exerc 1992; 24: 782–8PubMed
21.
go back to reference Gaesser GA, Brooks GA. Muscular efficiency during steady state exercise: effects of speed and work rate. J Appl Physiol 1975; 38: 1132–9PubMed Gaesser GA, Brooks GA. Muscular efficiency during steady state exercise: effects of speed and work rate. J Appl Physiol 1975; 38: 1132–9PubMed
22.
go back to reference Wasserman K, Hansen JE, Sue D, et al. editors. Principles of exercise testing and interpretation. 4th ed. Philadelphia (PA): Lippincot Williams and Wilkins, 2005: 11–53 Wasserman K, Hansen JE, Sue D, et al. editors. Principles of exercise testing and interpretation. 4th ed. Philadelphia (PA): Lippincot Williams and Wilkins, 2005: 11–53
23.
go back to reference Hansen JE, Casaburi R, Cooper DM, et al. Oxygen uptake as related to work rate increment during cycle ergometer exercise. Eur J Appl Physiol 1988; 57: 140–5CrossRef Hansen JE, Casaburi R, Cooper DM, et al. Oxygen uptake as related to work rate increment during cycle ergometer exercise. Eur J Appl Physiol 1988; 57: 140–5CrossRef
24.
go back to reference Zoladz JA, Rademaker AC, Sargeant AJ. Non-linear relationship between O2 uptake and power output at high intensities of exercise in humans. J Physiol 1995; 488: 211–7PubMed Zoladz JA, Rademaker AC, Sargeant AJ. Non-linear relationship between O2 uptake and power output at high intensities of exercise in humans. J Physiol 1995; 488: 211–7PubMed
25.
go back to reference Barstow TJ, Jones AM, Nguyen PH, et al. Influence of muscle fibre type and fitness on the oxygen uptake/power output slope during incremental exercise in humans. Exp Physiol 2000; 85: 109–16PubMedCrossRef Barstow TJ, Jones AM, Nguyen PH, et al. Influence of muscle fibre type and fitness on the oxygen uptake/power output slope during incremental exercise in humans. Exp Physiol 2000; 85: 109–16PubMedCrossRef
26.
go back to reference Scheuermann BW, McConnell JHT, Barstow TJ. EMG and oxygen uptake responses during slow and fast ramp exercise in humans. Exp Physiol 2002; 87: 91–100PubMedCrossRef Scheuermann BW, McConnell JHT, Barstow TJ. EMG and oxygen uptake responses during slow and fast ramp exercise in humans. Exp Physiol 2002; 87: 91–100PubMedCrossRef
27.
go back to reference Lucia A, Rivero JP, Serrano AL, et al. Determinants of \(\dot V\)O2 kinetics at high power outputs during a ramp exercise protocol. Med Sci Sports Exerc 2002; 34: 326–31PubMedCrossRef Lucia A, Rivero JP, Serrano AL, et al. Determinants of \(\dot V\)O2 kinetics at high power outputs during a ramp exercise protocol. Med Sci Sports Exerc 2002; 34: 326–31PubMedCrossRef
28.
go back to reference Pedersen PK, Sörensen JB, Jensen K, et al. Muscle fibre type distribution and nonlinear \(\dot V\)O2/power output relationship in cycling. Med Sci Sports Exerc 2002; 34: 655–61PubMedCrossRef Pedersen PK, Sörensen JB, Jensen K, et al. Muscle fibre type distribution and nonlinear \(\dot V\)O2/power output relationship in cycling. Med Sci Sports Exerc 2002; 34: 655–61PubMedCrossRef
29.
go back to reference Zoladz JA, Duda K, Majerczak J. Oxygen uptake does not increase linearly at high power outputs during incremental exercise test in humans. Eur J Appl Occup Physiol 1998; 77: 445–51CrossRef Zoladz JA, Duda K, Majerczak J. Oxygen uptake does not increase linearly at high power outputs during incremental exercise test in humans. Eur J Appl Occup Physiol 1998; 77: 445–51CrossRef
30.
go back to reference Bickham DC, Gibbons C, Le Rossignol PF. \(\dot V\)O2 is attenuated above the lactate threshold in endurance-trained runners. Med Sci Sports Exerc 2004; 36: 297–301PubMedCrossRef Bickham DC, Gibbons C, Le Rossignol PF. \(\dot V\)O2 is attenuated above the lactate threshold in endurance-trained runners. Med Sci Sports Exerc 2004; 36: 297–301PubMedCrossRef
31.
go back to reference Lucia A, Hoyos J, Santalla A, et al. Kinetics of \(\dot V\)O2 in professional cyclists. Med Sci Sports Exerc 2002; 34: 320–5PubMedCrossRef Lucia A, Hoyos J, Santalla A, et al. Kinetics of \(\dot V\)O2 in professional cyclists. Med Sci Sports Exerc 2002; 34: 320–5PubMedCrossRef
32.
go back to reference Zoladz JA, Korzeniewski B. Physiological background of the change point in \(\dot V\)O2 and the slow component of oxygen uptake kinetics. J Physiol Pharmacol 2001; 52: 167–84PubMed Zoladz JA, Korzeniewski B. Physiological background of the change point in \(\dot V\)O2 and the slow component of oxygen uptake kinetics. J Physiol Pharmacol 2001; 52: 167–84PubMed
33.
go back to reference Poole DC, Schaffartzik W, Knight DR, et al. Contribution of exercising legs to the slow component of oxygen uptake kinetics in humans. J Appl Physiol 1991; 71: 1245–53PubMed Poole DC, Schaffartzik W, Knight DR, et al. Contribution of exercising legs to the slow component of oxygen uptake kinetics in humans. J Appl Physiol 1991; 71: 1245–53PubMed
34.
go back to reference Gollnick PD, Piehl K, Saltin B. Selective glycogen depletion pattern in human muscle fibres after exercise of varying intensity and at varying pedalling rates. J Physiol (London) 1974; 241: 45–57 Gollnick PD, Piehl K, Saltin B. Selective glycogen depletion pattern in human muscle fibres after exercise of varying intensity and at varying pedalling rates. J Physiol (London) 1974; 241: 45–57
35.
go back to reference Cannon DT, White AC, Andriano MF, et al. Skeletal muscle fatigue precedes the slow component of oxygen uptake kinetics during exercise in humans. J Physiol 2011; 589: 727–39PubMedCrossRef Cannon DT, White AC, Andriano MF, et al. Skeletal muscle fatigue precedes the slow component of oxygen uptake kinetics during exercise in humans. J Physiol 2011; 589: 727–39PubMedCrossRef
36.
go back to reference Zoladz JA, Gladden BL, Hogan MC, et al. Progressive recruitment of muscle fibers is not necessary for the slow component of \(\dot V\)O2 kinetics. J Appl Physiol 2008; 105: 575–80PubMedCrossRef Zoladz JA, Gladden BL, Hogan MC, et al. Progressive recruitment of muscle fibers is not necessary for the slow component of \(\dot V\)O2 kinetics. J Appl Physiol 2008; 105: 575–80PubMedCrossRef
37.
go back to reference Gore CJ, Clark RJ, Shipp NJ, et al. CPX/D underestimates \(\dot V\)O2 in athletes compared with an automated Douglas bag system. Med Sci Sports Exerc 2003; 35: 1341–7PubMedCrossRef Gore CJ, Clark RJ, Shipp NJ, et al. CPX/D underestimates \(\dot V\)O2 in athletes compared with an automated Douglas bag system. Med Sci Sports Exerc 2003; 35: 1341–7PubMedCrossRef
38.
go back to reference Day JR, Rossiter HB, Coats EM, et al. The maximally attainable \(\dot V\)O2 during exercise in humans: the peak vs. maximum issue. J Appl Physiol 2003; 95: 1901–7 Day JR, Rossiter HB, Coats EM, et al. The maximally attainable \(\dot V\)O2 during exercise in humans: the peak vs. maximum issue. J Appl Physiol 2003; 95: 1901–7
40.
go back to reference Hughson RL, Inman MD. Oxygen uptake kinetics from ramp work tests: variability of single test values. J Appl Physiol 1986; 61: 373–6PubMed Hughson RL, Inman MD. Oxygen uptake kinetics from ramp work tests: variability of single test values. J Appl Physiol 1986; 61: 373–6PubMed
42.
go back to reference Hintzy-Cloutier H, Zameziati K, Belli A. Influence of the base-line determination on work efficiency during sub-maximal cycling. J Sports Med Phys Fitness 2003; 43: 51–6PubMed Hintzy-Cloutier H, Zameziati K, Belli A. Influence of the base-line determination on work efficiency during sub-maximal cycling. J Sports Med Phys Fitness 2003; 43: 51–6PubMed
43.
go back to reference Kautz SA, Neptune RR. Biomechanical determinants of pedalling energetics: internal and external work are not independent. Exerc Sport Sci Rev 2002; 30: 159–65PubMedCrossRef Kautz SA, Neptune RR. Biomechanical determinants of pedalling energetics: internal and external work are not independent. Exerc Sport Sci Rev 2002; 30: 159–65PubMedCrossRef
44.
go back to reference Neptune RR, Kautz SA. Muscle activation and deactivation dynamics: the governing properties in fast cyclical human movement performance. Exerc Sports Sci Rev 2001; 29:76–81CrossRef Neptune RR, Kautz SA. Muscle activation and deactivation dynamics: the governing properties in fast cyclical human movement performance. Exerc Sports Sci Rev 2001; 29:76–81CrossRef
45.
go back to reference Hansen EA, Andersen JL, Nielsen JS. Muscle fibre type, efficiency and mechanical optima affect freely chosen pedal rate during cycling. Acta Physiol Scand 2002; 176: 185–94PubMedCrossRef Hansen EA, Andersen JL, Nielsen JS. Muscle fibre type, efficiency and mechanical optima affect freely chosen pedal rate during cycling. Acta Physiol Scand 2002; 176: 185–94PubMedCrossRef
46.
go back to reference Takaishi T, Ono T, Yasuda Y. Relationship between muscle fatigue and oxygen uptake during cycle ergometer exercise with different ramp slope increments. Eur J Appl Physiol 1992; 65: 335–9CrossRef Takaishi T, Ono T, Yasuda Y. Relationship between muscle fatigue and oxygen uptake during cycle ergometer exercise with different ramp slope increments. Eur J Appl Physiol 1992; 65: 335–9CrossRef
47.
go back to reference Beelen A, Sargeant AJ. Effect of prior exercise at different pedalling frequencies on maximal power in humans. Eur J Appl Physiol 1993; 66: 102–7CrossRef Beelen A, Sargeant AJ. Effect of prior exercise at different pedalling frequencies on maximal power in humans. Eur J Appl Physiol 1993; 66: 102–7CrossRef
48.
49.
go back to reference Zoladz JA, Duda K, Majerczak J. \(\dot V\)O2/power output relationship and the slow component of oxygen uptake kinetics during cycling at different pedaling rates: relationship to venous lactate accumulation and blood acid-base balance. Physiol Res 1998; 47: 427–38PubMed Zoladz JA, Duda K, Majerczak J. \(\dot V\)O2/power output relationship and the slow component of oxygen uptake kinetics during cycling at different pedaling rates: relationship to venous lactate accumulation and blood acid-base balance. Physiol Res 1998; 47: 427–38PubMed
50.
go back to reference Fukuba Y, Hayashi N, Koga S, et al. \(\dot V\)O2 kinetics in heavy exercise is not altered by prior exercise with a different muscle group. J Appl Physiol 2002; 92: 2467–76PubMedCrossRef Fukuba Y, Hayashi N, Koga S, et al. \(\dot V\)O2 kinetics in heavy exercise is not altered by prior exercise with a different muscle group. J Appl Physiol 2002; 92: 2467–76PubMedCrossRef
51.
go back to reference Jones AM, Koppo K, Burnley M. Effect of prior exercise on metabolic and gas exchange responses to exercise. Sports Med 2003; 33: 949–71PubMedCrossRef Jones AM, Koppo K, Burnley M. Effect of prior exercise on metabolic and gas exchange responses to exercise. Sports Med 2003; 33: 949–71PubMedCrossRef
52.
go back to reference Jones AM, Carter H. Oxygen uptake-work rate relationship during two consecutive ramp exercise tests. Int J Sports Med 2004; 25: 415–20PubMedCrossRef Jones AM, Carter H. Oxygen uptake-work rate relationship during two consecutive ramp exercise tests. Int J Sports Med 2004; 25: 415–20PubMedCrossRef
53.
go back to reference Boone J, Bouckaert J, Barstow TJ, et al. Influence of priming high intensity exercise on the deoxy[hb+Mb] response to ramp exercise. Eur J Appl Physiol 2012; 112: 1143–52PubMedCrossRef Boone J, Bouckaert J, Barstow TJ, et al. Influence of priming high intensity exercise on the deoxy[hb+Mb] response to ramp exercise. Eur J Appl Physiol 2012; 112: 1143–52PubMedCrossRef
54.
go back to reference Marles A, Mucci P, Legrand R, et al. Effect of prior exercise on the \(\dot V\)O2/work rate relationship during incremental exercise and constant work rate exercise. Int J Sports Med 2006; 27: 345–50PubMedCrossRef Marles A, Mucci P, Legrand R, et al. Effect of prior exercise on the \(\dot V\)O2/work rate relationship during incremental exercise and constant work rate exercise. Int J Sports Med 2006; 27: 345–50PubMedCrossRef
55.
go back to reference Crow MT, Kushmerick MJ. Chemical energetics of slow-and fast-twitch muscles of the mouse. J Gen Physiol 1982; 79: 147–66PubMedCrossRef Crow MT, Kushmerick MJ. Chemical energetics of slow-and fast-twitch muscles of the mouse. J Gen Physiol 1982; 79: 147–66PubMedCrossRef
56.
go back to reference Kushmerick MJ, Meyer RA, Brown RT. Regulation of oxygen uptake consumption in fast- and slow-twitch muscle. Am J Physiol 1992; 236: C598–606 Kushmerick MJ, Meyer RA, Brown RT. Regulation of oxygen uptake consumption in fast- and slow-twitch muscle. Am J Physiol 1992; 236: C598–606
57.
go back to reference Willis WT, Jackman MR. Mitochondrial function during heavy exercise. Med Sci Sports Exerc 1994; 26: 1347–54PubMed Willis WT, Jackman MR. Mitochondrial function during heavy exercise. Med Sci Sports Exerc 1994; 26: 1347–54PubMed
58.
go back to reference Vollestad NK, Blom PCS. Effect of varying exercise intensity on glycogen depletion in human muscle fibres. Acta Physiol Scand 1985; 125: 395–405PubMedCrossRef Vollestad NK, Blom PCS. Effect of varying exercise intensity on glycogen depletion in human muscle fibres. Acta Physiol Scand 1985; 125: 395–405PubMedCrossRef
59.
go back to reference Barstow TJ, Jones AM, Nguyen PH, et al. Influence of muscle fibre type and pedal frequency on oxygen uptake kinetics of heavy exercise. J Appl Physiol 1996; 81: 1642–50PubMed Barstow TJ, Jones AM, Nguyen PH, et al. Influence of muscle fibre type and pedal frequency on oxygen uptake kinetics of heavy exercise. J Appl Physiol 1996; 81: 1642–50PubMed
60.
go back to reference Mogensen M, Bagger M, Pedersen PK, et al. Cycling efficiency in humans is related to low UCP3 content and to type I fibres but not to mitochondrial efficiency. J Physiol 2006; 571: 669–81PubMedCrossRef Mogensen M, Bagger M, Pedersen PK, et al. Cycling efficiency in humans is related to low UCP3 content and to type I fibres but not to mitochondrial efficiency. J Physiol 2006; 571: 669–81PubMedCrossRef
61.
go back to reference Medbø JI. Type I and type II fibres work with the same mechanical efficiency during bicycling. In: Maréchal G, Carraro U (eds). Muscle and mobility. Vol. 2. Hampshire: Intercept Ltd, 1990: 303–8 Medbø JI. Type I and type II fibres work with the same mechanical efficiency during bicycling. In: Maréchal G, Carraro U (eds). Muscle and mobility. Vol. 2. Hampshire: Intercept Ltd, 1990: 303–8
62.
go back to reference Costill DL, Fink WJ, Pollock ML. Muscle fibre composition and enzyme activities of elite distance runners. Med Sci Sports Exerc 1976; 8: 96–100 Costill DL, Fink WJ, Pollock ML. Muscle fibre composition and enzyme activities of elite distance runners. Med Sci Sports Exerc 1976; 8: 96–100
63.
go back to reference Casaburi R, Storer TW, Ben-Dov I, et al. Effect of endurance training on possible determinants of \(\dot V\)O2 during heavy exercise. J Appl Physiol 1987; 62: 199–207PubMed Casaburi R, Storer TW, Ben-Dov I, et al. Effect of endurance training on possible determinants of \(\dot V\)O2 during heavy exercise. J Appl Physiol 1987; 62: 199–207PubMed
64.
go back to reference Hagberg JM, Hickson RC, Ehsani AA, et al. Faster adjustment to and recovery from submaximal exercise in the trained state. J Appl Physiol 1980; 48: 218–24PubMed Hagberg JM, Hickson RC, Ehsani AA, et al. Faster adjustment to and recovery from submaximal exercise in the trained state. J Appl Physiol 1980; 48: 218–24PubMed
65.
go back to reference Koppo K, Bouckaert J, Jones AM. Effects of training status and exercise intensity on phase II \(\dot V\)O2 kinetics. Med Sci Sports Exerc 2004; 36: 225–32PubMedCrossRef Koppo K, Bouckaert J, Jones AM. Effects of training status and exercise intensity on phase II \(\dot V\)O2 kinetics. Med Sci Sports Exerc 2004; 36: 225–32PubMedCrossRef
66.
go back to reference Boone J, Koppo K, Barstow TJ, et al. Aerobic fitness, muscle efficiency and motor unit recruitment during ramp exercise. Med Sci Sports Exerc 2010; 42: 402–8PubMed Boone J, Koppo K, Barstow TJ, et al. Aerobic fitness, muscle efficiency and motor unit recruitment during ramp exercise. Med Sci Sports Exerc 2010; 42: 402–8PubMed
67.
go back to reference Mallory LA, Scheuermann BW, Hoelting BD, et al. Influence of peak \(\dot V\)O2 and muscle fibre type on the efficiency of moderate exercise. Med Sci Sports Exerc 2002; 34: 1279–87PubMedCrossRef Mallory LA, Scheuermann BW, Hoelting BD, et al. Influence of peak \(\dot V\)O2 and muscle fibre type on the efficiency of moderate exercise. Med Sci Sports Exerc 2002; 34: 1279–87PubMedCrossRef
68.
go back to reference Neder JA, Nery LE, Peres C, et al. Reference values for dynamic responses to incremental cycle ergometry in males and females aged 20 to 80. Am J Respir Crit Care Med 2001; 164: 1481–6PubMedCrossRef Neder JA, Nery LE, Peres C, et al. Reference values for dynamic responses to incremental cycle ergometry in males and females aged 20 to 80. Am J Respir Crit Care Med 2001; 164: 1481–6PubMedCrossRef
69.
go back to reference Kilding AE, Jones AM. \(\dot V\)O2 ‘overshoot’ during moderate-intensity exercise in endurance-trained athletes: The influence of exercise modality. Respir Physiol Neurobiol 2008; 160: 139–46PubMedCrossRef Kilding AE, Jones AM. \(\dot V\)O2 ‘overshoot’ during moderate-intensity exercise in endurance-trained athletes: The influence of exercise modality. Respir Physiol Neurobiol 2008; 160: 139–46PubMedCrossRef
70.
go back to reference Koppo K, Whipp BJ, Jones AM, et al. Overshoot in \(\dot V\)O2 following the onset of moderate-intensity cycle exercise in trained cyclists. Eur J Appl Physiol 2004; 93: 366–73PubMedCrossRef Koppo K, Whipp BJ, Jones AM, et al. Overshoot in \(\dot V\)O2 following the onset of moderate-intensity cycle exercise in trained cyclists. Eur J Appl Physiol 2004; 93: 366–73PubMedCrossRef
71.
go back to reference Barclay CJ. Mechanical efficiency and fatigue of fast and slow muscles of the mouse. J Physiol 1996; 497: 781–94PubMed Barclay CJ. Mechanical efficiency and fatigue of fast and slow muscles of the mouse. J Physiol 1996; 497: 781–94PubMed
72.
go back to reference Prieur F, Benoit H, Busso J, et al. Effect of endurance training on the \(\dot V\)O2 -work rate relationship in normoxia and hypoxia. Med Sci Sports Exerc 2005; 37: 664–9PubMedCrossRef Prieur F, Benoit H, Busso J, et al. Effect of endurance training on the \(\dot V\)O2 -work rate relationship in normoxia and hypoxia. Med Sci Sports Exerc 2005; 37: 664–9PubMedCrossRef
73.
go back to reference Gross MA, Breil FA, Lehamn AD, et al. Seasonal variation of \(\dot V\)O2 max and the \(\dot V\)O2 -work rate relationship in elite alpine skiers. Med Sci Sports Exerc 2009; 41: 2084–9PubMedCrossRef Gross MA, Breil FA, Lehamn AD, et al. Seasonal variation of \(\dot V\)O2 max and the \(\dot V\)O2 -work rate relationship in elite alpine skiers. Med Sci Sports Exerc 2009; 41: 2084–9PubMedCrossRef
74.
go back to reference Gimenes AC, Neder JA, Dal Corso S, et al. Relationship between work rate and oxygen uptake in mitochondrial myopathy during ramp-incremental exercise. Braz J Med Biol Res 2011; 44: 354–60PubMed Gimenes AC, Neder JA, Dal Corso S, et al. Relationship between work rate and oxygen uptake in mitochondrial myopathy during ramp-incremental exercise. Braz J Med Biol Res 2011; 44: 354–60PubMed
75.
go back to reference Itoh H. Oxygen uptake: work rate relationship in patients with heart disease. Med Sci Sports Exerc 1992; 37: 374–80 Itoh H. Oxygen uptake: work rate relationship in patients with heart disease. Med Sci Sports Exerc 1992; 37: 374–80
76.
go back to reference Jones S, Elliot PM, Sharma S, et al. Cardiopulmonary responses to exercise in patients with hypertrophic cardiomyopathy. Heart 1998; 80: 60–7PubMed Jones S, Elliot PM, Sharma S, et al. Cardiopulmonary responses to exercise in patients with hypertrophic cardiomyopathy. Heart 1998; 80: 60–7PubMed
77.
go back to reference Toyofuku M, Takaki H, Sugimachi M, et al. Reduced oxygen uptake increase to work rate increment (Δ \(\dot V\)O2/DW) is predictable by \(\dot V\)O2 response to constant work rate exercise in patients with chronic heart failure. Eur J Appl Physiol 2003; 90: 76–82PubMedCrossRef Toyofuku M, Takaki H, Sugimachi M, et al. Reduced oxygen uptake increase to work rate increment (Δ \(\dot V\)O2/DW) is predictable by \(\dot V\)O2 response to constant work rate exercise in patients with chronic heart failure. Eur J Appl Physiol 2003; 90: 76–82PubMedCrossRef
78.
go back to reference Balady GJ, Arena R, Sietsema K. Clinician’s guide to cardiopulmonary exercise testing in adults: a scientific statement from the American Heart Association. Circulation 2010; 122: 191–225PubMedCrossRef Balady GJ, Arena R, Sietsema K. Clinician’s guide to cardiopulmonary exercise testing in adults: a scientific statement from the American Heart Association. Circulation 2010; 122: 191–225PubMedCrossRef
79.
go back to reference Lewis MI, Belman MJ, Monn SA, et al. The relationship between oxygen consumption and work rate in patients with airflow obstruction. Chest 1994; 106: 366–72PubMedCrossRef Lewis MI, Belman MJ, Monn SA, et al. The relationship between oxygen consumption and work rate in patients with airflow obstruction. Chest 1994; 106: 366–72PubMedCrossRef
Metadata
Title
The Oxygen Uptake Response to Incremental Ramp Exercise
Methodogical and Physiological Issues
Authors
Mr Jan Boone
Jan Bourgois
Publication date
01-06-2012
Publisher
Springer International Publishing
Published in
Sports Medicine / Issue 6/2012
Print ISSN: 0112-1642
Electronic ISSN: 1179-2035
DOI
https://doi.org/10.2165/11599690-000000000-00000

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