Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Surgery Today
Published in: Surgery Today 11/2017

01-11-2017 | Original Article

The outcomes of pediatric liver retransplantation from a living donor: a 17-year single-center experience

Authors: Kohei Miura, Seisuke Sakamoto, Keita Shimata, Masaki Honda, Takashi Kobayashi, Toshifumi Wakai, Yasuhiko Sugawara, Yukihiro Inomata

Published in: Surgery Today | Issue 11/2017

Login to get access

Abstract

Purpose

Liver retransplantation is the only therapeutic option for patients with graft failure after liver transplantation. The aim of this study is to evaluate the outcomes of pediatric retransplantation from living donor at a single center.

Methods

Between December 1998 to August 2015, retransplantation from a living donor was performed for 14 children (<18 years of age) at Kumamoto University Hospital. The characteristics of the retransplantation recipient and the clinicopathological factors between primary transplantation and retransplantation were analyzed to detect the prognostic factors.

Results

In retransplantation, the operative time was longer and the amount of blood loss was greater in comparison to primary transplantation. The 1-, 3-, and 5-year survival rates from the date of retransplantation were 85.7, 85.7, and 78.6%, respectively. The rates of re-laparotomy after primary transplantation, bile leakage and postoperative bleeding after retransplantation were higher than after primary transplantation. Among the three patients who died after retransplantation, the operative time, the rate of re-laparotomy after primary transplantation and the incidence of gastrointestinal complications were higher in comparison to the surviving patients.

Conclusion

Pediatric retransplantation from a living donor is an acceptable procedure that could save the lives of recipients with failing allografts when organs from deceased donors are scarce. To ensure good results, it is essential to make an appropriate assessment of the cardiopulmonary function and the infectious state of the patients before Re-LDLT.
Literature
1.
D’Alessandro AM, Ploeg RJ, Knechtle SJ, Pirsch JD, Stegall MD, Hoffmann R, et al. Retransplantation of the liver—a seven-year experience. Transplantation. 1993;55:1083–7.CrossRefPubMed
2.
Mora NP, Klintmalm GB, Cofer JB, Solomon H, Goldstein RM, Gonwa TA, et al. Results after liver retransplantation in a group of 50 regrafted patients: two different concepts of elective versus emergency retransplantation. Transpl Int. 1991;4:231–4.CrossRefPubMed
3.
Heffron TG, Pillen T, Smallwood G, Henry S, Sekar S, Solis D, et al. Liver retransplantation in children: the Atlanta experience. Pediatr Transplant. 2010;14:417–25.CrossRefPubMed
4.
Bourdeaux C, Brunati A, Janssen M, de Magnée C, Otte JB, Sokal E, et al. Liver retransplantation in children. A 21-year single-center experience. Transpl Int. 2009;22:416–22.CrossRefPubMed
5.
Ng V, Anand R, Martz K, Fecteau A. Liver retransplantation in children: a SPLIT database analysis of outcome and predictive factors for survival. Am J Transpl. 2008;8:386–95.CrossRef
6.
Sieders E, Peeters PM, TenVergert EM, de Jong KP, Porte RJ, Zwaveling JH, et al. Retransplantation of the liver in children. Transplantation. 2001;71:90–5.CrossRefPubMed
7.
Achilleos OA, Mirza DF, Talbot D, McKiernan P, Beath SV, Gunson BK, et al. Outcome of liver retransplantation in children. Liver Transpl Surg. 1999;5:401–6.CrossRefPubMed
8.
Hamada H, Valayer J, Gauthier F, Yandza T, Takahashi H. Liver retransplantation in children. J Pediatr Surg. 1995;30:705–8.CrossRefPubMed
9.
Ogura Y, Kaihara S, Haga H, Kozaki K, Ueda M, Oike F, et al. Outcomes for pediatric liver retransplantation from living donors. Transplantation. 2003;76:943–8.CrossRefPubMed
10.
Urahashi T, Mizuta K, Sanada Y, Wakiya T, Umehara M, Hishikawa S, et al. Pediatric liver retransplantation from living donors can be considered as a therapeutic option for patients with irreversible living donor graft failure. Pediatr Transpl. 2011;15:798–803.CrossRef
11.
Broelsch CE, Emond JC, Whitington PF, Thistlethwaite JR, Baker AL, Lichtor JL. Application of reduced-size liver transplants as split grafts, auxiliary orthotopic grafts, and living related segmental transplants. Ann Surg. 1990;212:368–75 (discussion 375–7).
12.
Brölsch CE, Stevens LH, Whitington PF. The use of reduced-size liver transplants in children, including split livers and living related liver transplants. Eur J Pediatr Surg. 1991;1:166–71.CrossRefPubMed
13.
Piper JB, Whitington PF, Woodle ES, Newell KA, Alonso EM, Emond JC, et al. Pediatric liver transplantation at the University of Chicago Hospitals. Clin Transpl. 1992;179–89.
14.
Tanaka K, Kiuchi T. Living-donor liver transplantation in the new decade: perspective from the twentieth to the twenty-first century. J Hepatobiliary Pancreat Surg. 2002;9:218–22.CrossRefPubMed
15.
Malagó M, Testa G, Marcos A, Fung JJ, Siegler M, Cronin DC, et al. Ethical considerations and rationale of adult-to-adult living donor liver transplantation. Liver Transpl. 2001;7:921–7.CrossRefPubMed
16.
Strong RW, Lynch SV. Ethical issues in living related donor liver transplantation. Transpl Proc. 1996;28:2366–9.
17.
Shiffman M, Brown RS, Olthoff KM, Everson G, Miller C, Siegler M, et al. Living donor liver transplantation: summary of a conference at The National Institutes of Health. Liver Transpl. 2002;8:174–88.CrossRefPubMed
18.
Hibi T, Itano O, Shinoda M, Kitagawa Y. Liver transplantation for hepatobiliary malignancies: a new era of “Transplant Oncology” has begun. Surg Today. 2017;47:403–15.CrossRefPubMed
19.
Eguchi S, Soyama A, Nagai K, Miyazaki Y, Kurihara S, Hidaka M, et al. The donor advocacy team: a risk management program for living organ, tissue, and cell transplant donors. Surg Today. 2017;. doi:10.​1007/​s00595-017-1468-z.
20.
The Japanese Liver Transplantation Society. Liver transplantation in Japan (part 1)—registry by the Japanese Liver Transplantation Society (in Japanese with English abstract). Jpn J Transpl. 2013;48:362–8.
21.
Shneider BL. Progressive intrahepatic cholestasis: mechanisms, diagnosis and therapy. Pediatr Transpl. 2004;8:609–12.CrossRef
22.
Hori T, Egawa H, Takada Y, Ueda M, Oike F, Ogura Y, et al. Progressive familial intrahepatic cholestasis: a single-center experience of living-donor liver transplantation during two decades in Japan. Clin Transpl. 2011;25:776–85.CrossRef
23.
Newell KA, Millis JM, Bruce DS, Woodle ES, Cronin DC, Loss G, et al. An analysis of hepatic retransplantation in children. Transplantation. 1998;65:1172–8.CrossRefPubMed
24.
Sieders E, Peeters PMJG, TenVergert EM, de Jong KP, Porte RJ, Zwaveling JH, et al. Graft loss after pediatric liver transplantation. Ann Surg. 2002;235:125–32.CrossRefPubMedPubMedCentral
25.
Deshpande RR, Rela M, Girlanda R, Bowles MJ, Muiesan P, Dhawan A, et al. Long-term outcome of liver retransplantation in children. Transplantation. 2002;74:1124–30.CrossRefPubMed
26.
Feier F, da Fonseca EA, Candido HL, Pugliese R, Benavides MR, Neiva R, et al. Outcomes and technical aspects of liver retransplantation with living donors in children. Pediatr Transpl. 2016;20:813–8.CrossRef
27.
Katayama H, Kurokawa Y, Nakamura K, Ito H, Kanemitsu Y, Masuda N, et al. Extended Clavien-Dindo classification of surgical complications: Japan Clinical Oncology Group postoperative complications criteria. Surg Today. 2016;46:668–85.CrossRefPubMed
Metadata
Title
The outcomes of pediatric liver retransplantation from a living donor: a 17-year single-center experience
Authors
Kohei Miura
Seisuke Sakamoto
Keita Shimata
Masaki Honda
Takashi Kobayashi
Toshifumi Wakai
Yasuhiko Sugawara
Yukihiro Inomata
Publication date
01-11-2017
Publisher
Springer Japan
Published in
Surgery Today / Issue 11/2017
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-017-1533-7

Other articles of this Issue 11/2017

Surgery Today 11/2017 Go to the issue

Review Article

Adjuvant therapy for locally advanced gastric cancer

Original Article

Sphingosine-1-phosphate/sphingosine kinase 1-dependent lymph node metastasis in esophageal squamous cell carcinoma

Original Article

Neoadjuvant CapeOx therapy followed by sphincter-preserving surgery for lower rectal cancer

Original Article

Amylase concentration in drainage fluid as a predictive factor for severe postoperative pancreatic fistula in patients with gastric cancer

Original Article

The surgical outcomes of lung cancer combined with interstitial pneumonia: a single-institution report

Original Article

The basal nutritional state of PDAC patients is the dominant factor for completing adjuvant chemotherapy