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01-05-2014 | Original Article

The outcome after surgical therapy of bisphosphonate-associated osteonecrosis of the jaw—results of a clinical case series with an average follow-up of 20 months

Authors: Philipp Stockmann, Moritz Burger, Cornelius von Wilmowsky, Tobias Ebker, Rainer Lutz, Anne Bauersachs, Emeka Nkenke, Friedrich Wilhelm Neukam, Falk Wehrhan

Published in: Clinical Oral Investigations | Issue 4/2014

Abstract

Objectives

The present case series evaluates the success rate of osteotomy and primary wound closure in patients with bisphosphonate-associated osteonecrosis of the jaw (BRONJ).

Materials and methods

Eighty patients suffering from BRONJ were included in the study. All patients received intravenous bisphosphonate therapy and underwent osteotomy and primary wound closure according to a standardised protocol. After discharge, the patients were reviewed on a regular basis over an average time period of 20 months.

Results

During follow-up in 11 patients, a recurrence of BRONJ occurred in the former operation field. Seventeen patients died due to their underlying disease. The success rate of osteotomy and primary wound closure in the treatment of BRONJ was calculated at 84.2 % 20 months after surgery. The results showed non-significant difference concerning the outcome of surgery in the different clinical stages of BRONJ.

Conclusions

In accordance with previous studies, stage-independent osteotomy and primary wound closure combined with antibiotics shall be deemed a viable treatment option in patients suffering from BRONJ.

Clinical relevance

With a high success rate, osteotomy in combination with primary wound closure seems to be a viable alternative to more conservative protocols in the treatment of BRONJ.

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Title: The outcome after surgical therapy of bisphosphonate-associated osteonecrosis of the jaw—results of a clinical case series with an average follow-up of 20 months
Authors: Philipp Stockmann
Moritz Burger
Cornelius von Wilmowsky
Tobias Ebker
Rainer Lutz
Anne Bauersachs
Emeka Nkenke
Friedrich Wilhelm Neukam
Falk Wehrhan
Publication date: 01-05-2014
Publisher: Springer Berlin Heidelberg
Published in: Clinical Oral Investigations / Issue 4/2014
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-013-1092-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The outcome after surgical therapy of bisphosphonate-associated osteonecrosis of the jaw—results of a clinical case series with an average follow-up of 20 months

Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical relevance

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical relevance

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