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Published in: Acta Neuropathologica 5/2019

01-05-2019 | Review

The origin, fate, and contribution of macrophages to spinal cord injury pathology

Authors: Lindsay M. Milich, Christine B. Ryan, Jae K. Lee

Published in: Acta Neuropathologica | Issue 5/2019

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Abstract

Virtually all phases of spinal cord injury pathogenesis, including inflammation, cell proliferation and differentiation, as well as tissue remodeling, are mediated in part by infiltrating monocyte-derived macrophages. It is now clear that these infiltrating macrophages have distinct functions from resident microglia and are capable of mediating both harmful and beneficial effects after injury. These divergent effects have been largely attributed to environmental cues, such as specific cytokines, that influence the macrophage polarization state. In this review, we also consider the possibility that different macrophage origins, including the spleen, bone marrow, and local self-renewal, may also affect macrophage fate, and ultimately their function that contribute to the complex pathobiology of spinal cord injury.
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Metadata
Title
The origin, fate, and contribution of macrophages to spinal cord injury pathology
Authors
Lindsay M. Milich
Christine B. Ryan
Jae K. Lee
Publication date
01-05-2019
Publisher
Springer Berlin Heidelberg
Published in
Acta Neuropathologica / Issue 5/2019
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI
https://doi.org/10.1007/s00401-019-01992-3

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