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01-01-2016 | Functional Neuroradiology

The neural correlates of anomia in the conversion from mild cognitive impairment to Alzheimer’s disease

Authors: Emanuele Pravatà, Joshua Tavernier, Ryan Parker, Hrvoje Vavro, Jacobo E. Mintzer, Maria Vittoria Spampinato

Published in: Neuroradiology | Issue 1/2016

Abstract

Introduction

Language impairment is frequently observed in patients with Alzheimer’s disease (AD): in this study, we investigated the extent and distribution of brain atrophy in subjects with conversion from mild cognitive impairment (MCI) to AD with and without naming difficulties.

Methods

This study was approved by the institutional review board and was HIPAA compliant. All subjects or their legal representatives gave informed consent for participation. Ninety-one subjects from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) with (N = 51) and without (N = 40) naming impairment as per the Boston Naming Test (BNT), underwent brain magnetic resonance (MR) imaging 12 months before, at AD diagnosis, and 12 months after. Structural MR images were processed using voxel-based morphometry. Cross-sectional comparisons and mixed ANOVA models for assessing regional gray matter (GM) volume differences were performed.

Results

As from 12 months prior to AD diagnosis, patients with naming difficulties showed distinct areas of greater GM loss in the left fusiform gyrus (Brodmann area 20) than patients without naming difficulties. Differences in the GM atrophy extended to the left hemisphere in the subsequent 12 months.

Conclusion

This study provided evidence of distinct patterns and dynamics of brain atrophy in AD patients with naming difficulties when compared to those with intact language, as early as 12 months prior to AD diagnosis and in the subsequent 12 months.

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Title: The neural correlates of anomia in the conversion from mild cognitive impairment to Alzheimer’s disease
Authors: Emanuele Pravatà
Joshua Tavernier
Ryan Parker
Hrvoje Vavro
Jacobo E. Mintzer
Maria Vittoria Spampinato
Publication date: 01-01-2016
Publisher: Springer Berlin Heidelberg
Published in: Neuroradiology / Issue 1/2016
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-015-1596-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The neural correlates of anomia in the conversion from mild cognitive impairment to Alzheimer’s disease

Abstract

Introduction

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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