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Journal of Cancer Research and Clinical Oncology

Published in:

01-10-2015 | Review – Cancer Research

The network of epithelial–mesenchymal transition: potential new targets for tumor resistance

Authors: Danupon Nantajit, Dong Lin, Jian Jian Li

Published in: Journal of Cancer Research and Clinical Oncology | Issue 10/2015

Abstract

Purpose

In multiple cell metazoans, the ability of polarized epithelial cells to convert to motile mesenchymal cells in order to relocate to another location is governed by a unique process termed epithelial–mesenchymal transition (EMT). While being an essential process of cellular plasticity for normal tissue and organ developments, EMT is found to be involved in an array of malignant phenotypes of tumor cells including proliferation and invasion, angiogenesis, stemness of cancer cells and resistance to chemo-radiotherapy. Although EMT is being extensively studied and demonstrated to play a key role in tumor metastasis and in sustaining tumor hallmarks, there is a lack of clear picture of the overall EMT signaling network, wavering the potential clinical trials targeting EMT.

Methods

In this review, we highlight the potential key therapeutic targets of EMT linked with tumor aggressiveness, hypoxia, angiogenesis and cancer stem cells, emphasizing on an emerging EMT-associated NF-κB/HER2/STAT3 pathway in radioresistance of breast cancer stem cells.

Results

Further definition of cancer stem cell repopulation due to EMT-controlled tumor microenvironment will help to understand how tumors exploit the EMT mechanisms for their survival and expansion advantages.

Conclusions

The knowledge of EMT will offer more effective targets in clinical trials to treat therapy-resistant metastatic lesions.

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Title: The network of epithelial–mesenchymal transition: potential new targets for tumor resistance
Authors: Danupon Nantajit
Dong Lin
Jian Jian Li
Publication date: 01-10-2015
Publisher: Springer Berlin Heidelberg
Published in: Journal of Cancer Research and Clinical Oncology / Issue 10/2015
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-014-1840-y

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