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Published in: High Blood Pressure & Cardiovascular Prevention 1/2013

01-03-2013 | Original Article

The Neglected Role of the Electrocardiogram in the Diagnostic Work-Up of Hypertensive Patients

A Study in Clinical Practice

Authors: Cesare Cuspidi, Annalisa Re, Raffaella Dell’Oro, Guido Grassi, Carla Sala

Published in: High Blood Pressure & Cardiovascular Prevention | Issue 1/2013

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Abstract

Introduction

The electrocardiogram (ECG) is listed among the routine diagnostic examinations for hypertensive patients according to international guidelines.

Objective

The aim of this survey was to investigate whether an ECG is routinely prescribed before an echocardiographic examination by general practitioners for the evaluation of subclinical cardiac damage in uncomplicated hypertensive patients in a suburban area of Italy.

Methods

A total of 60 consecutive hypertensive patients (45 % men, mean age 60 ± 14 years) referred to a single out-patient cardiology service by their general practitioners for the assessment of cardiac organ damage by echocardiography were enrolled in the study. Patients’ demographic data and medical history were collected at the echocardiographic laboratory on a questionnaire administered by the attending physician.

Results

Less than 40 % of the study sample had undergone an ECG during the 12-month period preceding the echocardiographic examination. Notably, only 60 % of newly diagnosed hypertensive patents had an ECG done after the discovery of their hypertensive status.

Conclusions

These findings show that an ECG is not routinely prescribed as a first-line examination in the assessment of cardiac organ damage related to hypertension by a large fraction of general practitioners in current clinical practice in a northern area of Italy. This contrasts with available evidence that the combined assessment of left ventricular hypertrophy by ECG and echocardiogram provides the best evaluation of cardiac damage and stratification of cardiovascular risk in hypertension.
Literature
1.
go back to reference Levy D, Salomon M, D’Agostino RB, Belager AJ, Kannel WB. Prognostic implications of baseline electrocardiographic features and their serial changes in subjects with left ventricular hypertrophy. Circulation. 1994;90:1786–93.PubMedCrossRef Levy D, Salomon M, D’Agostino RB, Belager AJ, Kannel WB. Prognostic implications of baseline electrocardiographic features and their serial changes in subjects with left ventricular hypertrophy. Circulation. 1994;90:1786–93.PubMedCrossRef
2.
go back to reference Vakili BA, Okin PM, Devereux RB. Prognostic implications of left ventricular hypertrophy. Am Heart J. 2001;141:334–41.PubMedCrossRef Vakili BA, Okin PM, Devereux RB. Prognostic implications of left ventricular hypertrophy. Am Heart J. 2001;141:334–41.PubMedCrossRef
3.
go back to reference Bombelli M, Facchetti R, Carugo S, Madotto M, Arenare F, Quarti-Trevano F, et al. Left ventricular hypertrophy increases cardiovascular risk independently of in- and out-of office blood pressure values. J Hypertens. 2009;27:2458–64.PubMedCrossRef Bombelli M, Facchetti R, Carugo S, Madotto M, Arenare F, Quarti-Trevano F, et al. Left ventricular hypertrophy increases cardiovascular risk independently of in- and out-of office blood pressure values. J Hypertens. 2009;27:2458–64.PubMedCrossRef
4.
go back to reference Mathew J, Sleight P, Lonn E, Johnstone D, Pogue J, Yi Q, et al. Heart Outcomes Prevention Evaluation (HOPE) Investigators. Reduction of cardiovascular risk by regression of electrocardiographic markers of left ventricular hypertrophy by the angiotensin-converting enzyme inhibitor ramipril. Circulation. 2001;104:1615–21. Mathew J, Sleight P, Lonn E, Johnstone D, Pogue J, Yi Q, et al. Heart Outcomes Prevention Evaluation (HOPE) Investigators. Reduction of cardiovascular risk by regression of electrocardiographic markers of left ventricular hypertrophy by the angiotensin-converting enzyme inhibitor ramipril. Circulation. 2001;104:1615–21.
5.
go back to reference Pierdomenico SD, Cuccurullo F. Risk reduction after regression of echocardiographic left ventricular hypertrophy in hypertension: a meta-analysis. Am J Hypertens. 2010;23:876–81.PubMedCrossRef Pierdomenico SD, Cuccurullo F. Risk reduction after regression of echocardiographic left ventricular hypertrophy in hypertension: a meta-analysis. Am J Hypertens. 2010;23:876–81.PubMedCrossRef
6.
go back to reference Larstop AC, Okin PM, Devereux RB, Olsen MH, Ibsen H, Dahlof B, et al. Regression of ECG-LVH is associated with lower risk of new onset heart failure and mortality in patients with isolated systolic hypertension: the LIFE study. Am J Hypertens. (epub 21 June 2012). Larstop AC, Okin PM, Devereux RB, Olsen MH, Ibsen H, Dahlof B, et al. Regression of ECG-LVH is associated with lower risk of new onset heart failure and mortality in patients with isolated systolic hypertension: the LIFE study. Am J Hypertens. (epub 21 June 2012).
7.
go back to reference Costanzo P, Savarese G, Rosano G, Musella F, Casaretti L, Vassallo E, et al. Left ventricular hypertrophy reduction and clinical events: a meta-regression analysis of 14 studies in 12,809 hypertensive patients. Int J Cardiol. (epub 12 Jun 2012). Costanzo P, Savarese G, Rosano G, Musella F, Casaretti L, Vassallo E, et al. Left ventricular hypertrophy reduction and clinical events: a meta-regression analysis of 14 studies in 12,809 hypertensive patients. Int J Cardiol. (epub 12 Jun 2012).
8.
go back to reference The Seventh Report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure. The JNC 7 report. JAMA 2003; 289: 2560–2572. The Seventh Report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure. The JNC 7 report. JAMA 2003; 289: 2560–2572.
9.
go back to reference Guidelines for the management of arterial hypertension. The task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens. 2007;25:1105–87.CrossRef Guidelines for the management of arterial hypertension. The task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens. 2007;25:1105–87.CrossRef
10.
go back to reference Pewsner D, Juni P, Egger M, Battaglia M, Sundstrom J, Bachmann LM. Accuracy of electrocardiography in diagnosis of left ventricular hypertrophy in arterial hypertension: systematic review. BMJ. 2007;335:771–5.CrossRef Pewsner D, Juni P, Egger M, Battaglia M, Sundstrom J, Bachmann LM. Accuracy of electrocardiography in diagnosis of left ventricular hypertrophy in arterial hypertension: systematic review. BMJ. 2007;335:771–5.CrossRef
11.
go back to reference Cuspidi C, Ambrosioni E, Mancia G, Pessina AC, Trimarco B, Zanchetti A, on behalf of the APROS Investigators. Role of echocardiography and carotid ultrasonography in stratifying risk in patients with essential hypertension: the assessment of prognostic risk observational survey. J Hypertens. 2002;20:1307–14.PubMedCrossRef Cuspidi C, Ambrosioni E, Mancia G, Pessina AC, Trimarco B, Zanchetti A, on behalf of the APROS Investigators. Role of echocardiography and carotid ultrasonography in stratifying risk in patients with essential hypertension: the assessment of prognostic risk observational survey. J Hypertens. 2002;20:1307–14.PubMedCrossRef
12.
go back to reference Schillaci G, de Simone G, Reboldi G, Porcellati C, Devereux RB, Verdecchia C. Change in cardiovascular risk profile by echocardiography in low- or medium-risk hypertension. J Hypertens. 2002;20:1519–25.PubMedCrossRef Schillaci G, de Simone G, Reboldi G, Porcellati C, Devereux RB, Verdecchia C. Change in cardiovascular risk profile by echocardiography in low- or medium-risk hypertension. J Hypertens. 2002;20:1519–25.PubMedCrossRef
13.
go back to reference Nardi E, Palermo A, Mulè G, Cusimano P, Cerasola G, Rini GB. Prevalence and predictors of left ventricular hypertrophy in hypertensive patients with normal electrocardiogram. Eur J Prev Cardiol. (epub 3rd May 2012). Nardi E, Palermo A, Mulè G, Cusimano P, Cerasola G, Rini GB. Prevalence and predictors of left ventricular hypertrophy in hypertensive patients with normal electrocardiogram. Eur J Prev Cardiol. (epub 3rd May 2012).
14.
go back to reference Cuspidi C, Negri F, Giudici V, Capra A, Muiesan ML, Agabiti-Rosei E, de Simone G, et al. Echocardiography in clinical practice: the burden of arterial hypertension—a multicenter Italian survey. J Hum Hypertens. 2010;24:395–402.PubMedCrossRef Cuspidi C, Negri F, Giudici V, Capra A, Muiesan ML, Agabiti-Rosei E, de Simone G, et al. Echocardiography in clinical practice: the burden of arterial hypertension—a multicenter Italian survey. J Hum Hypertens. 2010;24:395–402.PubMedCrossRef
15.
go back to reference Devereux RB, Reickek N. Echocardiographic determination of left ventricular mass in man: anatomic validation of the method. Circulation. 1977;55:613–8.PubMedCrossRef Devereux RB, Reickek N. Echocardiographic determination of left ventricular mass in man: anatomic validation of the method. Circulation. 1977;55:613–8.PubMedCrossRef
16.
go back to reference Verdecchia P, Angeli F, Gattobigio R, Sardone M, Porcellati C. Asymptomatic left ventricular systolic dysfunction in essential hypertension: prevalence, determinants, and prognostic value. Hypertension. 2005;45:412–8.PubMedCrossRef Verdecchia P, Angeli F, Gattobigio R, Sardone M, Porcellati C. Asymptomatic left ventricular systolic dysfunction in essential hypertension: prevalence, determinants, and prognostic value. Hypertension. 2005;45:412–8.PubMedCrossRef
17.
go back to reference Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, Chamber Quantification Writing Group, American Society of Echocardiography’s Guidelines and Standards Committee, European Association of Echocardiography, et al. Recommendations for chamber quantification: a report from the American Society of Echocardiography’s guidelines and Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr. 2005;18:1440–63.PubMedCrossRef Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, Chamber Quantification Writing Group, American Society of Echocardiography’s Guidelines and Standards Committee, European Association of Echocardiography, et al. Recommendations for chamber quantification: a report from the American Society of Echocardiography’s guidelines and Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr. 2005;18:1440–63.PubMedCrossRef
18.
go back to reference Cuspidi C, Michev I, Lonati L, Vaccarella A, Cristofari M, Garavelli G, et al. Compliance to hypertension guidelines in clinical practice: a multicentre pilot study in Italy. J Hum Hypertens. 2002;16:699–703.PubMedCrossRef Cuspidi C, Michev I, Lonati L, Vaccarella A, Cristofari M, Garavelli G, et al. Compliance to hypertension guidelines in clinical practice: a multicentre pilot study in Italy. J Hum Hypertens. 2002;16:699–703.PubMedCrossRef
19.
go back to reference Cuspidi C, Valerio C, Sala C, Muiesan ML, Grandi AM, Palumbo G, et al. The Hyper-Pract : a multicentre survey on the accuracy of the echocardiographic assessment of hypertensive left ventricular hypertrophy in clinical practice. Blood Press. 2008;17:124–8.PubMedCrossRef Cuspidi C, Valerio C, Sala C, Muiesan ML, Grandi AM, Palumbo G, et al. The Hyper-Pract : a multicentre survey on the accuracy of the echocardiographic assessment of hypertensive left ventricular hypertrophy in clinical practice. Blood Press. 2008;17:124–8.PubMedCrossRef
20.
go back to reference Cuspidi C, Rescaldani M, Sala C, Negri F, Grassi G, Mancia G. Prevalence of electrocardiographic left ventricular hypertrophy in human hypertension: an updated review. J Hypertens. 2012;30:2066–73.PubMedCrossRef Cuspidi C, Rescaldani M, Sala C, Negri F, Grassi G, Mancia G. Prevalence of electrocardiographic left ventricular hypertrophy in human hypertension: an updated review. J Hypertens. 2012;30:2066–73.PubMedCrossRef
21.
go back to reference Sundstrom J, Lond L, Arnlov J, Zethelius B, Andren B, Lithell HO. Echocardiographic and electrocardiographic diagnoses of left ventricular hypertrophy predict mortality independently of each other in a population of elderly men. Circulation. 2001;103:2346–51.PubMedCrossRef Sundstrom J, Lond L, Arnlov J, Zethelius B, Andren B, Lithell HO. Echocardiographic and electrocardiographic diagnoses of left ventricular hypertrophy predict mortality independently of each other in a population of elderly men. Circulation. 2001;103:2346–51.PubMedCrossRef
22.
go back to reference Gerdts E, Okin PM, Borman K, Wacthtell K, Nierminen MS, Dahlof B, Devereux RB. Association of heart failure hospitalizations with combined electrocardiography and echocardiography criteria for left ventricular hypertrophy. Am J Hypertens. 2012;25:678–83.PubMedCrossRef Gerdts E, Okin PM, Borman K, Wacthtell K, Nierminen MS, Dahlof B, Devereux RB. Association of heart failure hospitalizations with combined electrocardiography and echocardiography criteria for left ventricular hypertrophy. Am J Hypertens. 2012;25:678–83.PubMedCrossRef
23.
go back to reference Cuspidi C, Meani S, Valerio C, Fusi V, Sala C, Zanchetti A. Left ventricular hypertrophy and cardiovascular risk stratification: impact and cost-effectiveness of echocardiography in recently diagnosed essential hypertensives. J Hypertens. 2006;24:1671–7.PubMedCrossRef Cuspidi C, Meani S, Valerio C, Fusi V, Sala C, Zanchetti A. Left ventricular hypertrophy and cardiovascular risk stratification: impact and cost-effectiveness of echocardiography in recently diagnosed essential hypertensives. J Hypertens. 2006;24:1671–7.PubMedCrossRef
Metadata
Title
The Neglected Role of the Electrocardiogram in the Diagnostic Work-Up of Hypertensive Patients
A Study in Clinical Practice
Authors
Cesare Cuspidi
Annalisa Re
Raffaella Dell’Oro
Guido Grassi
Carla Sala
Publication date
01-03-2013
Publisher
Springer International Publishing AG
Published in
High Blood Pressure & Cardiovascular Prevention / Issue 1/2013
Print ISSN: 1120-9879
Electronic ISSN: 1179-1985
DOI
https://doi.org/10.1007/s40292-013-0003-6

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