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Open Access 30-04-2024 | short review

The molecular tumor board—a key element of precision oncology

Authors: Dr. Laura Boos, MHBA, Prof. Dr. Dr. Andreas Wicki

Published in: memo - Magazine of European Medical Oncology

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Summary

Tumor profiling techniques have become an essential tool in cancer diagnostics creating an opportunity for individualized cancer care. Interpretation of results of molecular analyses and their integration into clinical practice, however, can be challenging. Molecular tumor boards play a key role in translating molecular findings into cancer treatment recommendations. In this short review we address important questions regarding the molecular tumor board set-up and highlight aspects of interest and challenges ahead.
Literature
1.
go back to reference Mateo J, Chakravarty D, Dienstmann R, et al. A framework to rank genomic alterations as targets for cancer precision medicine: the ESMO Scale for Clinical Actionability of molecular Targets (ESCAT). Ann Oncol. 2018;1;29(9):1895–902. Sep.CrossRef Mateo J, Chakravarty D, Dienstmann R, et al. A framework to rank genomic alterations as targets for cancer precision medicine: the ESMO Scale for Clinical Actionability of molecular Targets (ESCAT). Ann Oncol. 2018;1;29(9):1895–902. Sep.CrossRef
2.
go back to reference Tamborero D, Dienstmann R, Rachid MH, et al. The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology. Nat Cancer. 2022;3(2):251–61. Feb.CrossRefPubMedPubMedCentral Tamborero D, Dienstmann R, Rachid MH, et al. The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology. Nat Cancer. 2022;3(2):251–61. Feb.CrossRefPubMedPubMedCentral
3.
go back to reference Hoefflin R, Lazarou A, Hess ME, et al. Transitioning the Molecular Tumor Board from Proof of Concept to Clinical Routine: A German Single-Center Analysis. Cancers (basel). 2021;8;13(5):1151. Mar.CrossRefPubMed Hoefflin R, Lazarou A, Hess ME, et al. Transitioning the Molecular Tumor Board from Proof of Concept to Clinical Routine: A German Single-Center Analysis. Cancers (basel). 2021;8;13(5):1151. Mar.CrossRefPubMed
4.
go back to reference Kato S, Kim KH, Lim HJ, et al. Real-world data from a molecular tumor board demonstrates improved outcomes with a precision N‑of-One strategy. Nat Commun. 2020;2;11(1):4965. Oct.CrossRef Kato S, Kim KH, Lim HJ, et al. Real-world data from a molecular tumor board demonstrates improved outcomes with a precision N‑of-One strategy. Nat Commun. 2020;2;11(1):4965. Oct.CrossRef
5.
go back to reference Rieke DT, Lamping M, Schuh M, et al. Comparison of Treatment Recommendations by Molecular Tumor Boards Worldwide. Jco Precis Oncol. 2018;2:1–14. Nov.CrossRefPubMed Rieke DT, Lamping M, Schuh M, et al. Comparison of Treatment Recommendations by Molecular Tumor Boards Worldwide. Jco Precis Oncol. 2018;2:1–14. Nov.CrossRefPubMed
6.
go back to reference Schwaederle M, Parker BA, Schwab RB, et al. Molecular tumor board: the University of California-San Diego Moores Cancer Center experience. Oncologist. 2014;19(6):631–6. Jun.CrossRefPubMedPubMedCentral Schwaederle M, Parker BA, Schwab RB, et al. Molecular tumor board: the University of California-San Diego Moores Cancer Center experience. Oncologist. 2014;19(6):631–6. Jun.CrossRefPubMedPubMedCentral
7.
go back to reference Zehir A, Benayed R, Shah RH, et al. Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients. Nat Med. 2017;23(6):703–13. Jun.CrossRefPubMedPubMedCentral Zehir A, Benayed R, Shah RH, et al. Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients. Nat Med. 2017;23(6):703–13. Jun.CrossRefPubMedPubMedCentral
8.
go back to reference Wahida A, Buschhorn L, Fröhling S, et al. The coming decade in precision oncology: six riddles. Nat Rev Cancer. 2023;23(1):43–54. Jan.CrossRefPubMed Wahida A, Buschhorn L, Fröhling S, et al. The coming decade in precision oncology: six riddles. Nat Rev Cancer. 2023;23(1):43–54. Jan.CrossRefPubMed
9.
go back to reference Irmisch A, Bonilla X, Chevrier S, et al. The Tumor Profiler Study: integrated, multi-omic, functional tumor profiling for clinical decision support. Cancer Cell. 2021;8;39(3):288–93. Mar.CrossRef Irmisch A, Bonilla X, Chevrier S, et al. The Tumor Profiler Study: integrated, multi-omic, functional tumor profiling for clinical decision support. Cancer Cell. 2021;8;39(3):288–93. Mar.CrossRef
Metadata
Title
The molecular tumor board—a key element of precision oncology
Authors
Dr. Laura Boos, MHBA
Prof. Dr. Dr. Andreas Wicki
Publication date
30-04-2024
Publisher
Springer Vienna
Published in
memo - Magazine of European Medical Oncology
Print ISSN: 1865-5041
Electronic ISSN: 1865-5076
DOI
https://doi.org/10.1007/s12254-024-00977-7
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