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Critical Care
Published in: Critical Care 6/2002

01-12-2002 | Letter

The limitations of observational studies on the treatment of severe sepsis – authors' response

Authors: Andrea Messori, Franca Vacca, Monica Vaiani, Sabrina Trippoli

Published in: Critical Care | Issue 6/2002

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Excerpt

The observations by Wiederman et al. [1] on our recently published paper [2] raise some confusion between 'facts' and 'opinions'. In the area of the treatment of sepsis with antithrombin III, the results of our observational study are 'facts' and are therefore a contribution to a better knowledge of this therapeutic problem. While previous evidence was based only on randomised, controlled trials (RCTs), our study has provided some additional evidence using an observational design. Nobody can deny that having data from both RCTs and observational studies is better than having data from only RCTs. …
Literature
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Messori A, Vacca F, Vaiani M, Trippoli S, and the Gruppo di Studio sull'antitrombina III: Antithrombin III in patients admitted to intensive care units: a multicenter observational study. Crit Care 2002, 6: 447-451. 10.1186/cc1540PubMedCentralCrossRefPubMed
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Pocock SJ, Elbourne DR: Randomized trials of observational tribulations. N Engl J Med 2000, 342: 1907-1909. 10.1056/NEJM200006223422511CrossRefPubMed
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Benson K, Hartz AJ: A comparison of observational studies and randomised, controlled trials. N Engl J Med 2000, 342: 1878-1886. 10.1056/NEJM200006223422506CrossRefPubMed
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Concato J, Sha N, Horwitz RI: Randomized, controlled trials, observational studies, and the hierarchy of research designs. N Engl J Med 2000, 342: 1887-1892. 10.1056/NEJM200006223422507PubMedCentralCrossRefPubMed
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LeLorier J, Gregorier G, Benhaddad A, Lapierre J, Derderian F: Discrepancies between meta-analyses and subsequent larger randomised controlled trials. N Engl J Med 1997, 337: 536-542. 10.1056/NEJM199708213370806CrossRefPubMed
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Various authors: Meta-analyses and large randomized, controlled trials [seven letters]. N Engl J Med 1998, 338: 59-62. 10.1056/NEJM199801013380112CrossRef
Metadata
Title
The limitations of observational studies on the treatment of severe sepsis – authors' response
Authors
Andrea Messori
Franca Vacca
Monica Vaiani
Sabrina Trippoli
Publication date
01-12-2002
Publisher
BioMed Central
Published in
Critical Care / Issue 6/2002
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc1841

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