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EJNMMI Research
Published in: EJNMMI Research 1/2021

Open Access 01-12-2021 | Original research

The joint use of 99mTc-MAA-SPECT/CT and cone-beam CT optimizes radioembolization planning

Authors: Macarena Rodríguez-Fraile, Ana Ezponda, Fabiana Grisanti, Verónica Morán, Marta Calvo, Pablo Berián, Antonio Martínez de la Cuesta, Lidia Sancho, Mercedes Iñarrairaegui, Bruno Sangro, José Ignacio Bilbao

Published in: EJNMMI Research | Issue 1/2021

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Abstract

Purpose

To determine which imaging method used during radioembolization (RE) work-up: contrast-enhanced computed tomography (CECT), 99mTc-MAA-SPECT/CT or cone beam-CT (CBCT), more accurately predicts the final target volume (TgV) as well as the influence that each modality has in the dosimetric calculation.

Methods

TgVs from 99mTc-MAA-SPECT/CT, CECT and CBCT were consecutively obtained in 24 patients treated with RE and compared with 90Y PET/CT TgV. Using the TgVs estimated by each imaging modality and a fictitious activity of 1 GBq, the corresponding absorbed doses by tumor and non-tumoral parenchyma were calculated for each patient. The absorbed doses for each modality were compared with the ones obtained using 90Y PET/CT TgV.

Results

99mTc-MAA-SPECT/CT predicted 90Y PET/CT TgV better than CBCT or CECT, even for selective or superselective administrations. Likewise, 99mTc-MAA-SPECT/CT showed dosimetric values more similar to those obtained with 90Y PET/CT. Nevertheless, CBCT provided essential information for RE planning, such as ensuring the total coverage of the tumor and, in cases with more than one feeding artery, splitting the activity according to the volume of tumor perfused by each artery.

Conclusion

The joint use of 99mTc-MAA-SPECT/CT and CBCT optimizes dosimetric planning for RE procedures, enabling a more accurate personalized approach.
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Metadata
Title
The joint use of 99mTc-MAA-SPECT/CT and cone-beam CT optimizes radioembolization planning
Authors
Macarena Rodríguez-Fraile
Ana Ezponda
Fabiana Grisanti
Verónica Morán
Marta Calvo
Pablo Berián
Antonio Martínez de la Cuesta
Lidia Sancho
Mercedes Iñarrairaegui
Bruno Sangro
José Ignacio Bilbao
Publication date
01-12-2021
Publisher
Springer Berlin Heidelberg
Published in
EJNMMI Research / Issue 1/2021
Electronic ISSN: 2191-219X
DOI
https://doi.org/10.1186/s13550-021-00764-z

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