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Published in: CardioVascular and Interventional Radiology 1/2017

01-01-2017 | Rösch Lecture

The IR Evolution in Oncology: Tools, Treatments, and Guidelines

Author: Thierry de Baere

Published in: CardioVascular and Interventional Radiology | Issue 1/2017

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Abstract

Early focus of interventional oncologists was developing tools and imaging guidance, performing “procedures” acting as a skillful technician without knowledge of clinical patient outcomes, beyond post-treatment image findings. Interventional oncologists must deliver “treatments” and not “procedures”, and focus on clinically relevant outcomes, provide clinical continuity of care, which means stand at multidisciplinary tumor boards, see patients in consultation before treatment and for follow-up. Interventional oncologists have fought for the same “market” with surgery in a head to head, bloody competition called red ocean strategy in marketing terms, resulting in many aborted trials. Wide adoption of interventional oncology is facing the challenge to build evidence with overall survival as endpoint in randomized trials while the benefits of a treatment on overall survival are diluted by the effects of possible/inevitable subsequent therapies. Because interventional oncology is a disruptive force in medicine achieving same results as others (surgery) using different, less invasive approaches, patients where surgery is irrelevant can be target with a blue ocean strategy (to propose treatment where there is no competition). Recently interventional oncology has been included in the ESMO guidelines for colorectal cancer with oligometastatic disease with both surgical resection, and thermal ablation classified in the same category called “local ablative treatments”. Interventional oncologists have to shape the future by publications in oncologic journal, by being active members of oncology scientific societies, and use modern public megaphone (blog, video sharing, …) to disseminate information and let society know that interventional is not a me-too product but a disruptive treatment.
Footnotes
1
DDC is defined as the sum of PFS of each active treatment course. DDC excluded intervals between disease progression and re-initiation of treatment; PFS of inactive treatment if progressive disease occurred at first evaluation after treatment re-initiation (either reintroduction in stop-and-go strategy or subsequent course of treatment in multiline strategy).
 
2
TFS is defined as beginning with the initiation of the strategy under investigation and ending with the first of the following events: death; disease progression on the last received planned sequence; patient required the addition of a new therapeutic agent; patient experienced disease progression during a partial or complete break in therapy from initial treatment strategy and received no further therapy within 1 month.
 
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Metadata
Title
The IR Evolution in Oncology: Tools, Treatments, and Guidelines
Author
Thierry de Baere
Publication date
01-01-2017
Publisher
Springer US
Published in
CardioVascular and Interventional Radiology / Issue 1/2017
Print ISSN: 0174-1551
Electronic ISSN: 1432-086X
DOI
https://doi.org/10.1007/s00270-016-1503-2

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