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Surgical Endoscopy
Published in: Surgical Endoscopy 5/2014

01-05-2014

The inulin hydrogen breath test predicts the quality of colonic preparation

Authors: Donato F. Altomare, Leonilde Bonfrate, Marcin Krawczyk, Frank Lammert, Onofrio Caputi-Jambrenghi, Salvatore Rizzi, Michele Vacca, Piero Portincasa

Published in: Surgical Endoscopy | Issue 5/2014

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Abstract

Background

Successful bowel preparation is essential to an adequate performance of colonoscopy. Polyethylene glycol (PEG) with electrolyte solutions induces diarrhea with depletion of substrates fermentable by hydrogen (H2)-producing colonic microbiota. Inulin has recently been suggested as a prebiotic substrate for the H2 breath test because it is resistant to intestinal hydrolysis and is fermented mostly by the colonic bacteria. This study aimed to assess time-dependent changes in H2 breath levels in order to predict the colonic preparation of patients scheduled for colonoscopy with or without oral supplementation of inulin.

Methods

In this prospective nonrandomized trial, 127 subjects drank 4 l of PEG 280-mg solution as bowel preparation for colonoscopy. A subgroup of 31 patients also ingested inulin (10 g in 200 ml of water) at breakfast as an additional substrate to increase colonic H2 production. Measurements of H2 breath levels were performed immediately before and after colonic preparation. As the main outcome measure, the quality of the colonic preparation was scored as excellent to fair (i.e., clean bowel allowing successful pan-colonoscopy, including the terminal ileum) or poor (incomplete colonoscopy due to fecal debris).

Results

The H2 breath levels decreased from 11.0 ± 1.8 ppm before PEG to 1.8 ± 0.3 ppm after PEG (n = 18; P < 0.001). The H2 concentrations after PEG ingestion were significantly lower (P < 0.001) in the patients with excellent-to-fair preparation than in the 19 patients with poor preparation. Ingestion of inulin induced an overall increase in H2 breath levels and improved discrimination between the patients with excellent-to-fair colonic preparation and those with poor preparation, leading to the sensitivity and specificity of such a test reaching 100 %.

Conclusions

The H2 breath test with inulin ingestion can be a simple, noninvasive, reliable method for predicting successful colonic preparation that leads to cost savings and less patient discomfort/stress or need to repeat colonoscopy.
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Metadata
Title
The inulin hydrogen breath test predicts the quality of colonic preparation
Authors
Donato F. Altomare
Leonilde Bonfrate
Marcin Krawczyk
Frank Lammert
Onofrio Caputi-Jambrenghi
Salvatore Rizzi
Michele Vacca
Piero Portincasa
Publication date
01-05-2014
Publisher
Springer US
Published in
Surgical Endoscopy / Issue 5/2014
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI
https://doi.org/10.1007/s00464-013-3354-0

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