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02-04-2024 | Short Communication

The interplay between X-chromosome functional dosage and circadian regulation in females

Authors: Mariana Moysés-Oliveira, Monica L. Andersen, Sergio Tufik

Published in: Archives of Women's Mental Health

Abstract

Purpose

Biological factors and mechanisms that drive higher prevalence of insomnia in females are poorly understood. This study focused on the neurological consequences of X-chromosome functional imbalances between sexes.

Methods

Benefited from publicly available large-scale genetic, transcriptional and epigenomic data, we curated and contrasted different gene lists: (1) X-liked genes, including assignments for X-chromosome inactivation patterns and disease associations; (2) sleep-associated genes; (3) gene expression markers for the suprachiasmatic nucleus.

Results

We show that X-linked markers for the suprachiasmatic nucleus are significantly enriched for clinically relevant genes in the context of rare genetic syndromes and brain waves modulation.

Conclusion

Considering female-specific patterns on brain transcriptional programs becomes essential when designing health care strategies for mental and sleep illnesses with sex bias in prevalence.

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Title: The interplay between X-chromosome functional dosage and circadian regulation in females
Authors: Mariana Moysés-Oliveira
Monica L. Andersen
Sergio Tufik
Publication date: 02-04-2024
Publisher: Springer Vienna
Published in: Archives of Women's Mental Health
Print ISSN: 1434-1816
Electronic ISSN: 1435-1102
DOI: https://doi.org/10.1007/s00737-024-01452-2

At a glance: The STEP trials

Springer Medicine

The interplay between X-chromosome functional dosage and circadian regulation in females

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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