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Clinical Autonomic Research

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01-04-2010 | Research Article

The influence of vasovagal response on the coagulation system

Authors: Markus Kraemer, Markus Kuepper, Andrea Nebe-vom Stein, Ulrich Sorgenfrei, Rolf R. Diehl

Published in: Clinical Autonomic Research | Issue 2/2010

Abstract

Background

Vasovagal response (VVR) is provoked by a reduced venous blood return to the heart as a reaction to orthostatic stress and to haemorrhage. Recently, two cases were reported showing elevated plasma concentration of von-Willebrand-factor (VWF) and factor VIII (FVIII) after VVR due to venapuncture. Although the effect of epinephrine as trigger for VWF liberation is known, a connection between VVR and activation of the coagulation system has not been studied systematically.

Methods

We examined 21 subjects with lower body negative pressure. We measured the plasma concentration of von-Willebrand-factor-antigen (VWF:Ag), the activity of von-Willebrand-factor-Ristocetin-Cofactor (VWF:RiCo) and FVIII at several stress-levels and consecutively split up the different VWF-multimers.

Results

In 16 of 21 subjects VVR could be induced. These subjects showed a significant increase of VWF:Ag concentration in plasma and an increase of FVIII and VWF:RiCo activity. The five individuals who experienced all stress-levels without VVR did not show any changes in their clotting factor levels.

Conclusion

VVR leads to measurable changes in the coagulation system. This might be a further diagnostic tool in treating patients with syncope.

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Title: The influence of vasovagal response on the coagulation system
Authors: Markus Kraemer
Markus Kuepper
Andrea Nebe-vom Stein
Ulrich Sorgenfrei
Rolf R. Diehl
Publication date: 01-04-2010
Publisher: Springer-Verlag
Published in: Clinical Autonomic Research / Issue 2/2010
Print ISSN: 0959-9851
Electronic ISSN: 1619-1560
DOI: https://doi.org/10.1007/s10286-009-0022-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The influence of vasovagal response on the coagulation system

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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