Top

Published in:

01-06-2016 | Original Article

The influence of subthalamic nucleus stimulation on pragmatic language production in Parkinson’s disease

Authors: Sam Van Lier, Katja Batens, Patrick Santens, Dirk Van Roost, Mieke Van Herreweghe, Miet De Letter

Published in: Acta Neurologica Belgica | Issue 2/2016

Abstract

While the influence of deep brain stimulation (DBS) of the subthalamic nucleus (STN) on the comprehension of pragmatic language in Parkinson’s disease (PD) has been the focus of studies, its impact on production, however, has yet to be elucidated. (1) Investigating the inf luence of DBS STN on pragmatic language production in spontaneous speech by comparing different stimulation conditions and (2) evaluating the effect of asymmetric dopaminergic denervation. This paper included 18 patients with advanced idiopathic PD with STN DBS. [Ten PD patients with predominantly left hemispheric dopamine denervation (PD-left) and eight PD patients with predominantly right-hemispheric dopamine denervation (PD-right).] The pragmatic components ‘communicative functions’ and ‘conversational skills’ were evaluated by analysing the spontaneous language production in four stimulation conditions. STN stimulation did not appear to influence the pragmatic production skills. Only when asymmetric dopamine depletion was taken into account the parameter ‘giving an explanation’ interaction was detectable. STN DBS appears to have some influence on the production of pragmatic language depending on asymmetric dopaminergic denervation. Suggestions are made for further research of pragmatic production in Parkinson’s disease.

Bartels AL, Leenders KL (2009) Parkinson’s disease: the syndrome, the pathogenesis and pathophysiology. Cortex 45(8):915–921. doi:10.1016/j.cortex.2008.11.010 CrossRefPubMed

Jankovic J (2008) Parkinson’s disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry 79(4):368–376CrossRefPubMed

Kempster PA, Gibb WRG, Stern GM, Lees AJ (1989) Asymmetry of substantia nigra neuronal loss in Parkinson’s-disease and its relevance to the mechanism of levodopa related motor fluctuations. J Neurol Neurosurg Psychiatry 52(1):72–76. doi:10.1136/jnnp.52.1.72 CrossRefPubMedPubMedCentral

Djaldetti R, Ziv I, Melamed E (2006) The mystery of motor asymmetry in Parkinson’s disease. Lancet Neurol 5(9):796–802CrossRefPubMed

Antonini A, Vontobel P, Psylla M, Gunther I, Maguire PR, Missimer J, Leenders KL (1995) Complementary positron emission tomographic studies of the striatal dopaminergic system in Parkinson’s disease. Arch Neurol 52(12):1183CrossRefPubMed

Cronin-Golomb A (2010) Parkinson’s disease as a disconnection syndrome. Neuropsychol Rev 20(2):191–208CrossRefPubMedPubMedCentral

Verreyt N, Nys GMS, Santens P, Vingerhoets G (2011) Cognitive differences between patients with left-sided and right-sided Parkinson’s disease: a review. Neuropsychol Rev 21(4):405–424. doi:10.1007/s11065-011-9182-x CrossRefPubMed

Cubo E, Martinez Martín P, Martin-Gonzalez JA, Rodríguez-Blázquez C, Kulisevsky J (2010) Motor laterality asymmetry and nonmotor symptoms in Parkinson’s disease. Mov Disord 25(1):70–75CrossRefPubMed

Kempster PA, Gibb WR, Stern GM, Lees AJ (1989) Asymmetry of substantia nigra neuronal loss in Parkinson’s disease and its relevance to the mechanism of levodopa related motor fluctuations. J Neurol Neurosurg Psychiatry 52(1):72–76CrossRefPubMedPubMedCentral

10.

Riederer P, Sian-Hülsmann J (2012) The significance of neuronal lateralisation in Parkinson’s disease. J Neural Transm 119(8):953–962CrossRefPubMed

11.

Holtgraves T, Fogle K, Marsh L (2013) Pragmatic language production deficits in Parkinson’s disease. Adv Parkinson's Dis 2:31–36. doi:10.4236/apd.2013.21006 CrossRef

12.

Martin I, McDonald S (2003) Weak coherence, no theory of mind, or executive dysfunction? Solving the puzzle of pragmatic language disorders. Brain Lang 85(3):451–466CrossRefPubMed

13.

Geurts H, Embrechts M (2010) Pragmatics in pre-schoolers with language impairments. Int J Lang Commun Disord 45(4):436–447CrossRefPubMed

14.

Roth FP, Spekman NJ (1984) Assessing the pragmatic abilities of children. Part 1: Organizational framework and assessment parameters. J Speech Hear Disord 49(1):2–11CrossRefPubMed

15.

Eisele JA, Lust B, Aram DM (1998) Presupposition and implication of truth: linguistic deficits following early brain lesions. Brain Lang 61(3):376–394CrossRefPubMed

16.

McNamara P, Durso R (2003) Pragmatic communication skills in patients with Parkinson’s disease. Brain Lang 84(3):414–423. doi:10.1016/s0093-934x(02)00558-8 CrossRefPubMed

17.

Bordini BJ, Garg A, Gallagher CL, Bell B, Garell PC (2007) Neuropsychological effects of bilateral deep brain stimulation of the subthalamic nucleus in Parkinson’s disease. Stereotact Funct Neurosurg 85(2–3):113–120. doi:10.1159/000098526 CrossRefPubMed

18.

Lindell AK (2006) In your right mind: right hemisphere contributions to language processing and production. Neuropsychol Rev 16(3):131–148CrossRefPubMed

19.

Kuperberg G, McGuire P, Bullmore E, Brammer M, Rabe-Hesketh S, Wright I, Lythgoe D, Williams S, David A (2000) Common and distinct neural substrates for pragmatic, semantic, and syntactic processing of spoken sentences: an fMRI study. J Cogn Neurosci 12(2):321–341CrossRefPubMed

20.

Stowe LA, Haverkort M, Zwarts F (2005) Rethinking the neurological basis of language. Lingua 115(7):997–1042CrossRef

21.

Alexander MP, Benson DF, Stuss DT (1989) Frontal lobes and language. Brain Lang 37(4):656–691CrossRefPubMed

22.

AbdulSabur NY, Xu Y, Liu S, Chow HM, Baxter M, Carson J, Braun AR (2014) Neural correlates and network connectivity underlying narrative production and comprehension: a combined fMRI and PET study. Cortex 57:107–127CrossRefPubMed

23.

Tremblay C, Macoir J, Langlois M, Cantin L, Prud’homme M, Monetta L (2015) The effects of subthalamic deep brain stimulation on metaphor comprehension and language abilities in Parkinson’s disease. Brain Lang 141:103–109CrossRefPubMed

24.

Lewis FM, Lapointe LL, Murdoch BE, Chenery HJ (1998) Language impairment in Parkinson’s disease. Aphasiology 12(3):193–206CrossRef

25.

Monetta L, Grindrod CM, Pell MD (2009) Irony comprehension and theory of mind deficits in patients with Parkinson’s disease. Cortex 45(8):972–981CrossRefPubMed

26.

Berg E, Björnram C, Hartelius L, Laakso K, Johnels B (2003) High-level language difficulties in Parkinson’s disease. Clini Linguist Phon 17(1):63–80CrossRef

27.

Holtgraves T, McNamara P, Cappaert K, Durso R (2010) Linguistic correlates of asymmetric motor symptom severity in Parkinson’s Disease. Brain Cogn 72(2):189–196. doi:10.1016/j.bandc.2009.08.004 CrossRefPubMedPubMedCentral

28.

McKinlay A, Dalrymple-Alford J, Grace R, Roger D (2009) The effect of attentional set-shifting, working memory, and processing speed on pragmatic language functioning in Parkinson’s disease. Eur J Cogn Psychol 21(2–3):330–346CrossRef

29.

Gelb DJ, Oliver E, Gilman S (1999) Diagnostic criteria for Parkinson disease. Arch Neurol 56(1):33–39. doi:10.1001/archneur.56.1.33 CrossRefPubMed

30.

Dalrymple-Alford J, MacAskill M, Nakas C, Livingston L, Graham C, Crucian G, Melzer T, Kirwan J, Keenan R, Wells S (2010) The MoCA well-suited screen for cognitive impairment in Parkinson disease. Neurology 75(19):1717–1725CrossRefPubMed

31.

Van Strien JW (1992) Classificatie van links-en rechtshandige proefpersonen. Ned Tijdschr Psychol 47:88–92

32.

Kimura D (1961) Cerebral-dominance and the perception of verbal stimuli. Can J Psychol 15(3):166–171. doi:10.1037/h0083219 CrossRef

33.

Martens H, Van Nuffelen G, Van den Putte L, Wuyts F, De Bodt M (2010) Meten van spraakverstaanbaarheid op zinsniveau bij volwassenen met een spraakstoornis: introductie van het Nederlandstalig spraakverstaanbaarheidsonderzoek-zinsniveau (NSVO-Z). Logopedie 2:21–26

34.

Embrechts M, Mugge A, Van Bon W (2005) De Nijmeegse Pragmatiektest. Harcourt Test Publishers, Amsterdam

35.

Boersma P (2002) Praat, a system for doing phonetics by computer. Glot Int 5(9/10):341–345

36.

Yágüez L, Costello A, Moriarty J, Hulse N, Selway R, Clough C, Samuel M, Ashkan K (2014) Cognitive predictors of cognitive change following bilateral subthalamic nucleus deep brain stimulation in Parkinson’s disease. J Clin Neurosci 21(3):445–450CrossRefPubMed

37.

Batens K, De Letter M, Raedt R, Duyck W, Vanhoutte S, Van Roost D, Santens P (2014) The effects of subthalamic nucleus stimulation on semantic and syntactic performance in spontaneous language production in people with Parkinson’s disease. J Neurolinguist 32:31–41CrossRef

38.

Mitchell RL, Crow TJ (2005) Right hemisphere language functions and schizophrenia: the forgotten hemisphere? Brain 128(5):963–978CrossRefPubMed

39.

Perkins M (2012) Pragmatic Impairment. In: Damico J, Müller N, Ball M (eds) The handbook of language and speech disorders. Wiley-Blackwell, Oxford, pp 227–246

Title: The influence of subthalamic nucleus stimulation on pragmatic language production in Parkinson’s disease
Authors: Sam Van Lier
Katja Batens
Patrick Santens
Dirk Van Roost
Mieke Van Herreweghe
Miet De Letter
Publication date: 01-06-2016
Publisher: Springer International Publishing
Published in: Acta Neurologica Belgica / Issue 2/2016
Print ISSN: 0300-9009
Electronic ISSN: 2240-2993
DOI: https://doi.org/10.1007/s13760-015-0546-5

At a glance: The STEP trials

Springer Medicine

The influence of subthalamic nucleus stimulation on pragmatic language production in Parkinson’s disease

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 2/2016

Improvement of Bell’s palsy associated with resolution of acute hepatitis B infection

Drug adherence of patients with epilepsy in Iran: the effects of the international economic sanctions

Sonographic images of fetal terminal myelocystocele: a rare form of closed spinal dysraphism

The determinants of depression in a Romanian cohort of multiple sclerosis patients

A winged scapula and dropped wrist: an unusual manifestation of copper deficiency

Congenital methemoglobinemia type 2 and cerebellar atrophy/hypoplasia