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European Journal of Nuclear Medicine and Molecular Imaging

Published in:

01-10-2013 | Original Article

The increment in standardized uptake value determined using dual-phase ¹⁸F-FDG PET is a promising prognostic factor in non-small-cell lung cancer

Authors: Helen H. W. Chen, Bi-Fang Lee, Wu-Chou Su, Yu-Hsuan Lai, Hung-Yu Chen, How-Ran Guo, Wei-Jen Yao, Nan-Tsing Chiu

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 10/2013

Abstract

Purpose

We aimed to determine whether the increment in the maximal standardized uptake value (SUVmax) of the primary lung tumour between the initial and delayed imaging by dual-phase ¹⁸F-FDG PET has prognostic value in patients with non-small-cell lung cancer (NSCLC).

Methods

We reviewed the records of patients with NSCLC who underwent pretreatment dual-phase ¹⁸F-FDG PET/CT scans acquired at 1 h and 2 h after injection. The SUVmax increment (SUVinc) of the primary lung tumour was the 2-h SUVmax minus the 1-h SUVmax. Univariate and multivariate analyses were used to assess the prognostic significance of SUVinc, retention index, whole-body total metabolic tumour volume, whole-body total lesion glycolysis (TLGwb), 1-h SUVmax, 2-h SUVmax, gender, age, performance status, histological subtype, T stage, N stage and clinical stage.

Results

The records of 187 consecutive patients were reviewed. The median follow-up time was 3.9 years. The estimated median progression-free survival (PFS) and overall survival (OS) were 1.3 years and 4.4 years, respectively. An SUVinc cut-off value of >1 had the best discriminative yield for PFS. The 3-year PFS and OS were 61.6 % and 87.8 % in patients with SUVinc ≤1 versus 21.1 % and 46.2 % in patients with SUVinc >1 (all P < 0.01). Using the forward stepwise multivariate Cox proportional hazards model, SUVinc, TLGwb, and clinical stage were significant factors for PFS (all P < 0.01). A subgroup analysis of 117 patients treated with surgery showed that SUVinc (P = 0.02) and clinical stage (P < 0.01) were significant prognostic factors for PFS. Furthermore, in stage I patients treated with surgery alone, SUVinc was the only significant prognostic factor (HR 28.07; 95 % CI 2.42 – 326.41).

Conclusion

SUVinc determined from dual-phase ¹⁸F-FDG PET is a promising prognostic factor for NSCLC. It adds to the value of dual-phase ¹⁸F-FDG PET.

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Title: The increment in standardized uptake value determined using dual-phase 18F-FDG PET is a promising prognostic factor in non-small-cell lung cancer
Authors: Helen H. W. Chen
Bi-Fang Lee
Wu-Chou Su
Yu-Hsuan Lai
Hung-Yu Chen
How-Ran Guo
Wei-Jen Yao
Nan-Tsing Chiu
Publication date: 01-10-2013
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 10/2013
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-013-2452-5

At a glance: The STEP trials

Springer Medicine

The increment in standardized uptake value determined using dual-phase ¹⁸F-FDG PET is a promising prognostic factor in non-small-cell lung cancer

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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