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Cancer Immunology, Immunotherapy
Published in: Cancer Immunology, Immunotherapy 12/2009

01-12-2009 | Symposium in Writing

The importance of the age factor in cancer vaccination at older age

Author: Claudia Gravekamp

Published in: Cancer Immunology, Immunotherapy | Issue 12/2009

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Abstract

Cancer is an age-related disease, and with the graying of the society there is an increasing need to optimize cancer management and therapy to elderly patients. Vaccine therapy for cancer is less toxic than chemotherapy or radiation and could be, therefore, especially effective in older, more frail cancer patients. However, it has been shown that older individuals do not respond to vaccine therapy as well as younger adults. This has been attributed to T cell unresponsiveness, a phenomenon also observed in cancer patients per se. Therefore, research is needed to establish whether age-specific tumor-immunological variables permit optimal use of cancer vaccines and therapy in the elderly. This review summarizes the current knowledge of T cell unresponsiveness in cancer patients and elderly, and the results of cancer vaccination in preclinical models at young and old age. Finally, new directions that may lead to effective cancer vaccination at older age will be proposed.
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Metadata
Title
The importance of the age factor in cancer vaccination at older age
Author
Claudia Gravekamp
Publication date
01-12-2009
Publisher
Springer-Verlag
Published in
Cancer Immunology, Immunotherapy / Issue 12/2009
Print ISSN: 0340-7004
Electronic ISSN: 1432-0851
DOI
https://doi.org/10.1007/s00262-009-0683-x

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