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European Journal of Nuclear Medicine and Molecular Imaging
Published in: European Journal of Nuclear Medicine and Molecular Imaging 12/2011

01-12-2011 | Original Article

The importance of correction for tissue fraction effects in lung PET: preliminary findings

Authors: Tryphon Lambrou, Ashley M. Groves, Kjell Erlandsson, Nick Screaton, Raymondo Endozo, Thida Win, Joanna C Porter, Brian F. Hutton

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 12/2011

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Abstract

Purpose

It has recently been recognized that PET/CT may play a role in diffuse parenchymal lung disease. However, interpretation can be confounded due to the variability in lung density both within and between individuals. To address this issue a novel correction method is proposed.

Methods

A CT scan acquired during shallow breathing is registered to a PET study and smoothed so as to match the PET resolution. This is used to derive voxel-based tissue fraction correction factors for the individual. The method was evaluated in a lung phantom study in which the lung was simulated by a Styrofoam/water mixture. The method was further evaluated using 18F-FDG in 12 subjects free from pulmonary disease where ranges before and after correction were considered.

Results

Correction resulted in similar activity concentrations for the lung and background regions, consistent with the experimental phantom set-up. Correction resulted in reduced inter- and intrasubject variability in the estimated SUV. The possible application of the method was further demonstrated in five subjects with interstitial lung changes where increased SUV was demonstrated. Single study pre- and post-treatment studies were also analysed to further illustrate the utility of the method.

Conclusion

The proposed tissue fraction correction method is a promising technique to account for variability of density in interpreting lung PET studies.
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Metadata
Title
The importance of correction for tissue fraction effects in lung PET: preliminary findings
Authors
Tryphon Lambrou
Ashley M. Groves
Kjell Erlandsson
Nick Screaton
Raymondo Endozo
Thida Win
Joanna C Porter
Brian F. Hutton
Publication date
01-12-2011
Publisher
Springer-Verlag
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 12/2011
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-011-1906-x

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