Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
BMC Women's Health
Published in: BMC Women's Health 1/2018

Open Access 01-12-2018 | Research article

The impact of thyroid-stimulating hormone levels in euthyroid women on intrauterine insemination outcome

Authors: Gorkem Tuncay, Abdullah Karaer, Ebru İnci Coşkun, Demet Baloğlu, Ayşe Nihan Tecellioğlu

Published in: BMC Women's Health | Issue 1/2018

Login to get access

Abstract

Background

The aim of this study was to examine the effect of thyroid-stimulating hormone (TSH) levels on intrauterine insemination (IUI) outcomes among euthyroid women.

Methods

A retrospective cohort study was conducted. A total of 302 women who started their first IUI cycle in our fertility center were included in this study. The patients were categorized into two groups based on their preconception TSH values: 0.38–2.49 mIU/Land 2.50–4.99 mIU/L. The clinical pregnancy rate was the main outcome parameter. As secondary parameters, we evaluated the differences in spontaneous abortion rate, live-birth delivery rate, and perinatal outcomes according to the preconception TSH threshold (< 2.5 and < 5.00 mIU/L).

Results

There was no significant difference between the two groups with respect to clinical pregnancy, miscarriage, and live-birth rates with an odds ratio of 1.67 (95% CI: 0.79–3.53), 1.08 (95% CI: 0.09–13.1), and 1.79 (95% CI: 0.77–4.2), respectively. In addition, there were no significant differences in perinatal outcomes (gestation at delivery, birth weight, and neonatal intensive care unit–administration rate) between the two groups.

Conclusions

Our findings indicate that among euthyroid patients, preconception TSH values in the high-normal range (between 2.5 and 4.9 mIU/L) do not have a negative effect on IUI outcomes.

Trial registration

This study is retrospectively registered by Ethical Review Board at Inonu University in 19th December 2017; Ethics approval no is 2017–27-20.
Literature
1.
Ombolet W, Robays JV. Artificial insemination history: hurdles and milestones. Facts Views Vis Obgyn. 2015;7:137–43.
2.
Ombolet W, Campo R, Bosmans E, Nijs M. Intrauterine insemination (IUI) as a first-line treatment in developing countries and methodological aspects that might influence IUI success. Hum Reprod. 2008;1:64–72.
3.
Negro R, Mesuman JH. Thyroid disease in pregnancy. Best Pract Res Clin Endocrinol Met. 2011;25:927–43.CrossRef
4.
Poppe K, Velkeniers B, Glinoer D. Thyroid disease and female reproduction. Clin Endocrin. 2007;66:309–21.CrossRef
5.
Kim CH, Ahn JW, Kang SP, Kim SH, Chae HD, Kang BM. Effect of levothyroxine treatment on in vitro fertilization and pregnancy outcome in infertile women with subclinical hypothyroidism undergoing in vitro fertilization (intracytoplasmic sperm injection). Fertil Steril. 2010;94:2920–2.CrossRef
6.
Scoccia B, Demir H, Kang Y, Fierro MA, Winston NJ. In vitro fertilization pregnancy rates in levothyroxine-treated women with hypothyroidism compared to women without thyroid dysfunction disorders. Thyroid. 2012;22:631–6.CrossRefPubMedPubMedCentral
7.
Garber JR, Cobin RH, Gharib H, Hennessey JV, Klein I, Mechanick JI, et al. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American thyroid Assocciation. Endocr Pract. 2012;18:988–1028.CrossRefPubMed
8.
Alexander EK, Pearce EN, Brent GA, Brown RS, Chen H, Dosiu C, Grobman WA, Laurberg P, Lazarus JH, Mandel SJ, Peeters RP, Sulivan S. 2017 guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and the postpartum. Thyroid. 2017;27:315–89.CrossRefPubMed
9.
Nulsen JC, Walsh S, Dumez S, Metzger DA. A randomized and longitudinal study of human menopausal gonadotropin with intrauterine insemination in the treatment of infertility. Obstet Gynecol. 1993;82:780–6.PubMed
10.
Guzick DS, Carson SA, Coutifaris C, Overstreet JW, Factor-Litvak P, Steinkampf MP, Hill JA, Mastroianni L, Buster JE, Nakajima ST, Vogel DL, Canfiels RE. Efficacy of superovulation and intrauterine insemination in the treatment of infertility. National Cooperative Reproductive Medicine Network N Engl J Med. 1999;21:177–83.
11.
Rhemrev J, Jeyendran RS, Vermeiden JPW, Zaneveld LJD. Human sperm selection by glass wool filtration and two-layer, discontinuous Percoll gradient centrifugation. Fertil Steril. 1989;51:685–90.CrossRefPubMed
12.
World Health Organization. WHO laboratory manual for the examination and processing of human semen. 5th ed. Geneva: World Health Organization; 2010.
13.
Duran HE, Morshedi M, Kruger T, Oehninger S. Intrauterine insemination: a systematic review on determinants of success. Hum Reprod Update. 2002;8(4):373–84.CrossRefPubMed
14.
Reh A, Grifo J, Danoff A. What is a normal thyroid-stimulating hormone (TSH) level? Effects of stricter TSH thresholds on pregnancy outcomes after in vitro fertilization. Fertil Steril. 2010;94:2920–2.CrossRefPubMed
15.
Karmon AE, Batsis M, Chavarro JE, Souter I. Preconceptional throid-stimulating hormone levels and outcomes of intrauterine insemination among euthyroid infertile women. Fertil Steril. 2015;103:258–63.CrossRefPubMed
16.
Stagnaro-Green A, Abalovich M, Alexander E, Azizi F, Mestman J, Negro R, Nixon A, Pearce EN, Soldin OP, Sullivan S, Wiersinga W. American Thyroid Association taskforce on thyroid disease during pregnancy and postpartum 2011 guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid. 2011;21:1081–125.CrossRefPubMedPubMedCentral
17.
De Groot L, Abalovich M, Alexander EK, Amino N, Barbour L, Cobin RH, Eastman CJ, Lazarus JH, Luton D, Mandel SJ, Mestman J, Rovet J, Sullivan S. Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2012;97:2543–65.CrossRefPubMed
18.
Gilbert GM, Hadlow NC, Walsh JP, Fletcher SJ, Brown SJ, Stuckey BG, et al. Assessment of thyroid function during pregnancy: first trimester (weeks 9-13) reference interval derived from western Australian women. Mred J Aust. 2008;189:250–3.
19.
Li C, Shan Z, Mao J, Wang W, Xie X, Zhou W, Li C, Xu B, Bi L, Meng T, Du J, Zhang S, Gao Z, Zhang X, Yang L, Fan C, Teng W. Assessment of thyroid function during first-trimester pregnancy: what is the rational upper limit of serum TSH during the first trimester in Chinese pregnant women? J Clin Endocrinol Metab. 2014;99:73–9.CrossRefPubMed
20.
Marwaha RK, Chopra S, Gopalakrishnan S, Sharma B, Kanwar RS, Sastry A, Singh S. Establishment of reference range for thyroid hormones in normal pregnant Indian women. BJOG. 2008;115:602–6.CrossRefPubMed
21.
Moon HW, Chung HJ, Park CM, Hur M, Yun YM. Establishment of trimester-specific reference intervals for thyroid hormones in Korean pregnant women. Ann Lab Med. 2015;35:198–204.CrossRefPubMedPubMedCentral
22.
Practice Committee of the American Society for Reproductive Medicine. Subclinical hypothyroidism in the infertile female population. Fertil Steril. 2015;104:545–53.CrossRef
23.
Krassas GE, Poppe K, Glinoer D. Thyroid function and human reproductive health. Endocr Rev. 2010;31:702–55.CrossRefPubMed
Metadata
Title
The impact of thyroid-stimulating hormone levels in euthyroid women on intrauterine insemination outcome
Authors
Gorkem Tuncay
Abdullah Karaer
Ebru İnci Coşkun
Demet Baloğlu
Ayşe Nihan Tecellioğlu
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Women's Health / Issue 1/2018
Electronic ISSN: 1472-6874
DOI
https://doi.org/10.1186/s12905-018-0541-0

Other articles of this Issue 1/2018

BMC Women's Health 1/2018 Go to the issue

Research article

Trauma, attachment style, and somatization: a study of women with dyspareunia and women survivors of sexual abuse

Research article

Adversities and mental health needs of pregnant adolescents in Kenya: identifying interpersonal, practical, and cultural barriers to care

Research article

Contraceptive experience and perception, a survey among Ukrainian women

Research article

Selected indicators and determinants of women’s health in the vicinity of a copper mine development in northwestern Zambia

Research article

Pattern and determinants of contraceptive usage among women of reproductive age from the Digo community residing in Kwale, Kenya: results from a cross-sectional household survey

Research article

Dietary pattern and health-related quality of life among breast cancer survivors