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01-09-2018 | Original Article

The Impact of MDCT and Endoscopic Transpapillary Mapping Biopsy to Predict Longitudinal Spread of Extrahepatic Cholangiocarcinoma

Authors: Kyoji Ito, Yoshihiro Sakamoto, Hiroyuki Isayama, Yosuke Nakai, Takeyuki Watadani, Mariko Tanaka, Tetsuo Ushiku, Nobuhisa Akamatsu, Junichi Kaneko, Junichi Arita, Kiyoshi Hasegawa, Norihiro Kokudo

Published in: Journal of Gastrointestinal Surgery | Issue 9/2018

Abstract

Backgrounds

We aimed to investigate the diagnostic accuracy of multidetector-row computed tomography (MDCT), mapping biopsy, and other imaging modalities to predict the longitudinal extension and depth of invasion of extrahepatic cholangiocarcinoma at possible surgical ductal margins.

Methods

Of 102 patients with surgical resection of extrahepatic cholangiocarcinoma between January 2010 and October 2015, 32 evaluated by multidetector-row computed tomography (MDCT) performed before biliary drainage and mapping biopsy were enrolled. Mapping biopsies were performed at 74 sites to determine the resection point of the bile duct (at 74 possible surgical ductal margins). Diagnostic accuracy was evaluated by histopathology.

Results

The diagnostic accuracy of MDCT for longitudinal cancer spread was 79.7%, that of biopsy was 73.0%, and combining the two modalities showed highest accuracy (83.8%). The depth of tumor invasion could be predicted by combination of the ductal wall thickness and contrast enhancement on MDCT, that is, at 11 of 13 sites (84.6%) with submucosal invasion, ductal wall thickness was > 2.5 mm with high contrast enhancement.

Conclusions

MDCT demonstrated highest accuracy of diagnosing longitudinal extension at possible surgical ductal margins in patients with extrahepatic cholangiocarcinoma. The depth of tumor invasion could be predicted by ductal wall thickness and contrast enhancement of MDCT.

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Title: The Impact of MDCT and Endoscopic Transpapillary Mapping Biopsy to Predict Longitudinal Spread of Extrahepatic Cholangiocarcinoma
Authors: Kyoji Ito
Yoshihiro Sakamoto
Hiroyuki Isayama
Yosuke Nakai
Takeyuki Watadani
Mariko Tanaka
Tetsuo Ushiku
Nobuhisa Akamatsu
Junichi Kaneko
Junichi Arita
Kiyoshi Hasegawa
Norihiro Kokudo
Publication date: 01-09-2018
Publisher: Springer US
Published in: Journal of Gastrointestinal Surgery / Issue 9/2018
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-018-3793-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The Impact of MDCT and Endoscopic Transpapillary Mapping Biopsy to Predict Longitudinal Spread of Extrahepatic Cholangiocarcinoma

Abstract

Backgrounds

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Backgrounds

Methods

Results

Conclusions

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