Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
World Journal of Urology
Published in: World Journal of Urology 7/2016

01-07-2016 | Original Article

The impact of klotho gene polymorphisms on urinary tract stone disease

Authors: Abdullah Gürel, İyimser Üre, Halide Edip Temel, Oğuz Çilingir, Sema Uslu, Mehmet Fatih Celayir, Serap Aslan, Ali Barbaros Başeskioğlu

Published in: World Journal of Urology | Issue 7/2016

Login to get access

Abstract

Objectives

To investigate the effect of klotho gene and β-glucuronidase activity on stone formation in patients with urinary tract stone disease (UTSD).

Methods

A total of 103 patients with UTSD and 102 controls with no specific urolithiasis history were enrolled into the study. G395A and C1818T polymorphisms of klotho gene were analyzed with PCR method. Serum levels of calcium and phosphorus and 24-h urine levels of β-glucuronidase activity, calcium and phosphorus levels were measured biochemically.

Results

A total of 103 of patients were male (50.2 %) and 102 were female (49.8 %) (p 0.945). Twenty-four-hour urine levels of calcium were significantly higher in UTSD group, whereas no difference was observed in phosphorus levels (p < 0.001, p 0.074, respectively). As for the G395A polymorphism, type of GG was significantly higher in the patient group compared to the controls (p = 0.02), while GA genotype was significantly higher in the controls (p = 0.001). There was no significant difference in F352V and C1818T polymorphism between the patient and control groups. β-glucuronidase activity was slightly lower in the patient group without significance (p 0.932).When patients with GG genotype and the rest were compared, there were no significant difference in all parameters.

Conclusions

Any polymorphism altering the function of klotho gene may result with stone formation. We found that there are more GG sequences of G395A gene in patients with UTSD. That may be a polymorphism of klotho gene which results with stone formation. Further studies with more patients should be accomplished which are combining the genetic and epigenetic factors associated with urolithiasis and klotho gene to enlighten the etiology of this disease.
Literature
1.
Sarıca K (2007) Üriner sistem taş hastalığında epidemiyoloji. Üriner Sistem Taş Hastalığı. istanbul: nobel tıp kitapevi, 9–18
2.
Yoshida O, Okada Y (1990) Epidemiology of urolithiasis in Japan: a chronological and geographical study. Urol Int 45(2):104–111CrossRefPubMed
3.
Akinci M, Esen T, Tellaloğlu S (1991) Urinary stone disease in Turkey: an updated epidemiological study. Eur Urol 20(3):200–203PubMed
4.
Curhan GC, Rimm EB, Willett WC, Stampfer MJ (1994) Regional variation in nephrolithiasis incidence and prevalence among United States men. J Urol 151(4):838–841PubMed
5.
Borghi L, Ferretti PP, Elia GF, Amato F, Melloni E, Trapassi MR et al (1990) Epidemiological study of urinary tract stones in a northern Italian city. Br J Urol 65(3):231–235CrossRefPubMed
6.
7.
Stamatelou KK, Francis ME, Jones CA, Nyberg LM, Curhan GC (2003) Time trends in reported prevalence of kidney stones in the United States: 1976–1994. Kidney Int 63(5):1817–1823CrossRefPubMed
8.
Nabeshima Y (2008) Discovery of alpha-Klotho and FGF23 unveiled new insight into calcium and phosphate homeostasis. Clin Calcium 18(7):923–934PubMed
9.
Civitelli R, Ziambaras K (2011) Calcium and phosphate homeostasis: concerted interplay of new regulators. J Endocrinol Invest 34(7 Suppl):3–7PubMed
10.
Chang Q, Hoefs S, van der Kemp AW, Topala CN, Bindels RJ, Hoenderop JG (2005) The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel. Science 310(5747):490–493CrossRefPubMed
11.
Kurosu H, Ogawa Y, Miyoshi M, Yamamoto M, Nandi A, Rosenblatt KP et al (2006) Regulation of fibroblast growth factor-23 signaling by klotho. J Biol Chem 281(10):6120–6123CrossRefPubMedPubMedCentral
12.
Hu MC, Shi M, Zhang J, Pastor J, Nakatani T, Lanske B et al (2010) Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule. FASEB J Off Publ Fed Am Soc Exp Biol 24(9):3438–3450
13.
Razzaque MS, Lanske B (2007) The emerging role of the fibroblast growth factor-23-klotho axis in renal regulation of phosphate homeostasis. J Endocrinol 194(1):1–10CrossRefPubMedPubMedCentral
14.
15.
Davalos M, Konno S, Eshghi M, Choudhury M (2010) Oxidative renal cell injury induced by calcium oxalate crystal and renoprotection with antioxidants: a possible role of oxidative stress in nephrolithiasis. J Endourol Endourol Soc 24(3):339–345CrossRef
16.
Tungsanga K, Sriboonlue P, Futrakul P, Yachantha C, Tosukhowong P (2005) Renal tubular cell damage and oxidative stress in renal stone patients and the effect of potassium citrate treatment. Urol Res 33(1):65–69CrossRefPubMed
17.
Huang H-S, Ma M-C, Chen C-F, Chen J (2003) Lipid peroxidation and its correlations with urinary levels of oxalate, citric acid, and osteopontin in patients with renal calcium oxalate stones. Urology 62(6):1123–1128CrossRefPubMed
18.
Shimoyama Y, Nishio K, Hamajima N, Niwa T (2009) KLOTHO gene polymorphisms G-395A and C1818T are associated with lipid and glucose metabolism, bone mineral density and systolic blood pressure in Japanese healthy subjects. Clin Chim Acta Int J Clin Chem 406(1–2):134–138CrossRef
19.
Low AF, O’Donnell CJ, Kathiresan S, Everett B, Chae CU, Shaw SY et al (2005) Aging syndrome genes and premature coronary artery disease. BMC Med Genet 31(6):38CrossRef
20.
Cobben NA, Drent M, De Vries J, Wouters EF, Van Dieijen-Visser MP, Henderson RF (1999) Serum beta-glucuronidase activity in a population of ex-coalminers. Clin Biochem 32(8):659–664CrossRefPubMed
21.
Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T et al (1997) Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390(6655):45–51CrossRefPubMed
22.
Imura A, Iwano A, Tohyama O, Tsuji Y, Nozaki K, Hashimoto N et al (2004) Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane. FEBS Lett 565(1–3):143–147CrossRefPubMed
23.
Imura A, Tsuji Y, Murata M, Maeda R, Kubota K, Iwano A et al (2007) alpha-Klotho as a regulator of calcium homeostasis. Science 316(5831):1615–1618CrossRefPubMed
24.
Xu C, Song R, Yang J, Jiang B, Wang X, Wu W et al (2013) Klotho gene polymorphism of rs3752472 is associated with the risk of urinary calculi in the population of Han nationality in Eastern China. Gene 526(2):494–497CrossRefPubMed
25.
Telci D, Dogan AU, Ozbek E, Polat EC, Simsek A, Cakir SS et al (2011) KLOTHO gene polymorphism of G395A is associated with kidney stones. Am J Nephrol 33(4):337–343CrossRefPubMed
26.
Li S-A, Watanabe M, Yamada H, Nagai A, Kinuta M, Takei K (2004) Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice. Cell Struct Funct 29(4):91–99CrossRefPubMed
27.
28.
Metadata
Title
The impact of klotho gene polymorphisms on urinary tract stone disease
Authors
Abdullah Gürel
İyimser Üre
Halide Edip Temel
Oğuz Çilingir
Sema Uslu
Mehmet Fatih Celayir
Serap Aslan
Ali Barbaros Başeskioğlu
Publication date
01-07-2016
Publisher
Springer Berlin Heidelberg
Published in
World Journal of Urology / Issue 7/2016
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI
https://doi.org/10.1007/s00345-015-1732-z

Other articles of this Issue 7/2016

World Journal of Urology 7/2016 Go to the issue

Original Article

A comparison between laparoscopic and retroperitoneoscopic approach for partial nephrectomy in children with duplex kidney: a multicentric survey

Original Article

Prevalence of sexual dysfunction in men with chronic prostatitis/chronic pelvic pain syndrome: a meta-analysis

Original Article

Nighttime kidney transplantation is associated with less pure technical graft failure

Original Article

Low yield of surveillance imaging after surgery for T1 kidney cancer

Original Article

Kidney cancer focal cryoablation trend: does location or approach matter?

Original Article

AdVanceXP male sling: 2-year results of a multicentre study