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01-05-2009 | Original Article

The impact of incident fractures on health-related quality of life: 5 years of data from the Canadian Multicentre Osteoporosis Study

Authors: A. Papaioannou, C. C. Kennedy, G. Ioannidis, A. Sawka, W. M. Hopman, L. Pickard, J. P. Brown, R. G. Josse, S. Kaiser, T. Anastassiades, D. Goltzman, M. Papadimitropoulos, A. Tenenhouse, J. C. Prior, W. P. Olszynski, J. D. Adachi, for the CaMos Study Group

Published in: Osteoporosis International | Issue 5/2009

Abstract

Summary

Using prospective data from the Canadian Multicentre Osteoporosis Study (CaMos), we compared health utilities index (HUI) scores after 5 years of follow-up among participants (50 years and older) with and without incident clinical fractures. Incident fractures had a negative impact on HUI scores over time.

Introduction

This study examined change in health-related quality of life (HRQL) in those with and without incident clinical fractures as measured by the HUI.

Methods

The study cohort was 4,820 women and 1,783 men (50 years and older) from the CaMos. The HUI was administered at baseline and year 5. Participants were sub-divided into incident fracture groups (hip, rib, spine, forearm, pelvis, other) and were compared with those without these fractures. The effects of both time and fracture type on HUI scores were examined in multivariable regression analyses.

Results

Men and women with hip fractures, compared to those without, had lower HUI measures that ranged from −0.05 to −0.25. Both women and men with spine fractures had significant deficits on the pain attributes (−0.07 to −0.12). In women, self-care (−0.06), mobility and ambulation (−0.05) were also negatively impacted. Women with rib fractures had deficits similar to women with spine fractures, and these effects persisted over time. In men, rib fractures did not significantly affect HUI scores. Pelvic and forearm fractures did not substantially influence HUI scores.

Conclusion

The HUI was a sensitive measure of HRQL change over time. These results will inform economic analyses evaluating osteoporosis therapies.

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Title: The impact of incident fractures on health-related quality of life: 5 years of data from the Canadian Multicentre Osteoporosis Study
Authors: A. Papaioannou
C. C. Kennedy
G. Ioannidis
A. Sawka
W. M. Hopman
L. Pickard
J. P. Brown
R. G. Josse
S. Kaiser
T. Anastassiades
D. Goltzman
M. Papadimitropoulos
A. Tenenhouse
J. C. Prior
W. P. Olszynski
J. D. Adachi
for the CaMos Study Group
Publication date: 01-05-2009
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 5/2009
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-008-0743-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The impact of incident fractures on health-related quality of life: 5 years of data from the Canadian Multicentre Osteoporosis Study

Abstract

Summary

Introduction

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusion

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