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Neurocritical Care
Published in: Neurocritical Care 1/2010

01-02-2010 | Translational Research

The Hemodynamic Response of the Cerebral Bridging Veins to Changes in ICP

Authors: Yanbing Yu, Jie Chen, Zhichao Si, Guangyu Zhao, Shangchen Xu, Guangbin Wang, Feng Ding, Liming Luan, Lebin Wu, Qi Pang

Published in: Neurocritical Care | Issue 1/2010

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Abstract

Background

To investigate the hemodynamic response of the cerebral bridging veins to increased intracranial pressure (ICP) during normo- and hyperventilation.

Methods

Flow velocity (FVm), diameter (D), and pulsatility index (PI) were measured and calculated in the cerebral bridging veins using Color Doppler Ultrasound in seven pigs, and cerebral blood flow (CBF) was measured using 133Xe clearance in nine pigs, both during normo- and hyperventilation. ICP was increased stepwise from baseline (about 10 mmHg) to 20 and 30 mmHg by infusion of mock CSF into the cisterna magna.

Results

Moderate elevations of ICP caused venous relative stasis as evidenced by a decrease in FVm and increase in diameter and PI, but no change of volume flow in the veins. CBF was stable indicating autoregulation at ICP of 20 and 30 mmHg. Parallel observations were made during normo- and hyperventilation, but at two different levels of CBF.

Conclusions

The cerebral bridging veins dilation and blood flow velocity decrease indicate the venous relative stasis in response to the elevated ICP. This response is proposed to be caused by an ICP-dependent increase in resistance to the outflow from the cerebral bridging veins.
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Metadata
Title
The Hemodynamic Response of the Cerebral Bridging Veins to Changes in ICP
Authors
Yanbing Yu
Jie Chen
Zhichao Si
Guangyu Zhao
Shangchen Xu
Guangbin Wang
Feng Ding
Liming Luan
Lebin Wu
Qi Pang
Publication date
01-02-2010
Publisher
Humana Press Inc
Published in
Neurocritical Care / Issue 1/2010
Print ISSN: 1541-6933
Electronic ISSN: 1556-0961
DOI
https://doi.org/10.1007/s12028-009-9299-4

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