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European Journal of Epidemiology
Published in: European Journal of Epidemiology 12/2007

Open Access 01-12-2007 | DEVELOPMENTAL EPIDEMIOLOGY

The Generation R Study Biobank: a resource for epidemiological studies in children and their parents

Authors: Vincent W. V. Jaddoe, Rachel Bakker, Cock M. van Duijn, Albert J. van der Heijden, Jan Lindemans, Johan P. Mackenbach, Henriëtte A. Moll, Eric A. P. Steegers, Henning Tiemeier, Andre G. Uitterlinden, Frank C. Verhulst, Albert Hofman

Published in: European Journal of Epidemiology | Issue 12/2007

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Abstract

The Generation R Study is a population-based prospective cohort study from fetal life until young adulthood. The study is designed to identify early environmental and genetic causes of normal and abnormal growth, development and health from fetal life until young adulthood. In total, 9,778 mothers were enrolled in the study. Prenatal and postnatal data collection is conducted by physical examinations, questionnaires, interviews, ultrasound examinations and biological samples. Major efforts have been conducted for collecting biological specimens including DNA, blood for phenotypes and urine samples. In this paper, the collection, processing and storage of these biological specimens are described. Together with detailed phenotype measurements, these biological specimens form a unique resource for epidemiological studies focused on environmental exposures, genetic determinants and their interactions in relation to growth, health and development from fetal life onwards.
Literature
1.
Hofman A, Jaddoe VW, Mackenbach JP, Moll HA, Snijders RF, Steegers EA, Verhulst FC, Witteman JC, Buller HA. Growth, development and health from early fetal life until young adulthood: the Generation R Study. Paediatr Perinat Epidemiol 2004;18:61–72.PubMedCrossRef
2.
Jaddoe VW, Mackenbach JP, Moll HA, Steegers EA, Tiemeier H, Verhulst FC, Witteman JC, Hofman A. The Generation R Study: design and cohort profile. Eur J Epidemiol. 2006;21:475–84.PubMedCrossRef
3.
4.
Hirschhorn JN, Daly MJ. Genome-wide association studies for common diseases and complex traits. Nat Rev Genet 2005;6:95–108.PubMedCrossRef
5.
Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007;447:661–78.
6.
Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, Timpson NJ, Perry JR, Rayner NW, Freathy RM, Barrett JC, Shields B, Morris AP, Ellard S, Groves CJ, Harries LW, Marchini JL, Owen KR, Knight B, Cardon LR, Walker M, Hitman GA, Morris AD, Doney AS; Wellcome Trust Case Control Consortium (WTCCC), McCarthy MI, Hattersley AT. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 2007;316:1336–41.
7.
International Multiple Sclerosis Genetics Consortium, Hafler DA, Compston A, Sawcer S, Lander ES, Daly MJ, De Jager PL, de Bakker PI, Gabriel SB, Mirel DB, Ivinson AJ, Pericak-Vance MA, Gregory SG, Rioux JD, McCauley JL, Haines JL, Barcellos LF, Cree B, Oksenberg JR, Hauser SL. Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med 2007;357:851–6.
8.
Hofman A, Breteler MM, van Duijn CM, Krestin GP, Pols HA, Stricker BH, Tiemeier H, Uitterlinden AG, Vingerling JR, Witteman JC.The Rotterdam Study: objectives and design update. Eur J Epidemiol. 2007;22:819–29.
9.
Rours GI, Verkooyen RP, Willemse HF, van der Zwaan EA, van Belkum A, de Groot R, Verbrugh HA, Ossewaarde JM. Use of pooled urine samples and automated DNA isolation to achieve improved sensitivity and cost-effectiveness of large-scale testing for Chlamydia trachomatis in pregnant women. J Clin Microbiol. 2005;43:4684–90.PubMedCrossRef
10.
Jones RW, Ring S, Tyfield L, Hamvas R, Simmons H, Pembrey M, Golding J, ALSPAC Study Team. A new human genetic resource: a DNA bank established as part of the Avon longitudinal study of pregnancy and childhood (ALSPAC). Eur J Hum Genet. 2000;8:653–60.
11.
Olsen J, Melbye M, Olsen SF, Sorensen TI, Aaby P, Andersen AM, et al. The Danish National Birth Cohort—its background, structure and aim. Scand J Public Health 2001;29:300–7.PubMedCrossRef
12.
Ronningen KS, Paltiel L, Meltzer HM, Nordhagen R, Lie KK, Hovengen R, Haugen M, Nystad W, Magnus P, Hoppin JA. The biobank of the Norwegian mother and child Cohort Study: a resource for the next 100 years. Eur J Epidemiol. 2006;21:619–25.PubMedCrossRef
13.
Branum AM, Collman GW, Correa A, Keim SA, Kessel W, Kimmel CA, et al. The National Children’s Study of environmental effects on child health and development. Environ Health Perspect 2003;111:642–6.PubMed
14.
Inskip HM, Godfrey KM, Robinson SM, Law CM, Barker DJ, Cooper C. Cohort profile: The Southampton Women’s Survey. Int J Epidemiol 2006;35:42–8.PubMedCrossRef
Metadata
Title
The Generation R Study Biobank: a resource for epidemiological studies in children and their parents
Authors
Vincent W. V. Jaddoe
Rachel Bakker
Cock M. van Duijn
Albert J. van der Heijden
Jan Lindemans
Johan P. Mackenbach
Henriëtte A. Moll
Eric A. P. Steegers
Henning Tiemeier
Andre G. Uitterlinden
Frank C. Verhulst
Albert Hofman
Publication date
01-12-2007
Publisher
Springer Netherlands
Published in
European Journal of Epidemiology / Issue 12/2007
Print ISSN: 0393-2990
Electronic ISSN: 1573-7284
DOI
https://doi.org/10.1007/s10654-007-9209-z

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