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Head & Neck Oncology
Published in: Head & Neck Oncology 1/2011

Open Access 01-12-2011 | Meeting report

The future of medical diagnostics: review paper

Authors: Waseem K Jerjes, Tahwinder Upile, Brian J Wong, Christian S Betz, Henricus J Sterenborg, Max J Witjes, Kristian Berg, Robert van Veen, Merrill A Biel, Adel K El-Naggar, Charles A Mosse, Malini Olivo, Rebecca Richards-Kortum, Dominic J Robinson, Jennifer Rosen, Arjun G Yodh, Catherine Kendall, Justus F Ilgner, Arjen Amelink, Vanderlei Bagnato, Hugh Barr, Lina Bolotine, Irving Bigio, Zhongping Chen, Lin-Ping Choo-Smith, Anil K D'Cruz, Ann Gillenwater, Andreas Leunig, Alexander J MacRobert, Gordon McKenzie, Ann Sandison, Khee C Soo, Herbert Stepp, Nicholas Stone, Katarina Svanberg, I Bing Tan, Brian C Wilson, Herbert Wolfsen, Colin Hopper

Published in: Head & Neck Oncology | Issue 1/2011

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Abstract

While histopathology of excised tissue remains the gold standard for diagnosis, several new, non-invasive diagnostic techniques are being developed. They rely on physical and biochemical changes that precede and mirror malignant change within tissue. The basic principle involves simple optical techniques of tissue interrogation. Their accuracy, expressed as sensitivity and specificity, are reported in a number of studies suggests that they have a potential for cost effective, real-time, in situ diagnosis.
We review the Third Scientific Meeting of the Head and Neck Optical Diagnostics Society held in Congress Innsbruck, Innsbruck, Austria on the 11th May 2011. For the first time the HNODS Annual Scientific Meeting was held in association with the International Photodynamic Association (IPA) and the European Platform for Photodynamic Medicine (EPPM). The aim was to enhance the interdisciplinary aspects of optical diagnostics and other photodynamic applications. The meeting included 2 sections: oral communication sessions running in parallel to the IPA programme and poster presentation sessions combined with the IPA and EPPM posters sessions.
Literature
1.
Bagan JV, Scully C: Recent advances in Oral Oncology 2007: epidemiology, aetiopathogenesis, diagnosis and prognostication. Oral Oncol. 2008, 44 (2): 103-8. 10.1016/j.oraloncology.2008.01.008.CrossRefPubMed
2.
Warnakulasuriya S: Global epidemiology of oral and oropharyngeal cancer. Oral Oncol. 2009, 45 (4-5): 309-16. 10.1016/j.oraloncology.2008.06.002.CrossRefPubMed
3.
4.
Suhr MA, Hopper C, Jones L, George JG, Bown SG, MacRobert AJ: Optical biopsy systems for the diagnosis and monitoring of superficial cancer and precancer. Int J Oral Maxillofac Surg. 2000, 29 (6): 453-7. 10.1016/S0901-5027(00)80081-8.CrossRefPubMed
5.
Swinson B, Jerjes W, El-Maaytah M, Norris P, Hopper C: Optical techniques in diagnosis of head and neck malignancy. Oral Oncol. 2006, 42 (3): 221-8. 10.1016/j.oraloncology.2005.05.001.CrossRefPubMed
6.
Upile T, Jerjes W, Betz CS, El Maaytah M, Wright A, Hopper C: Optical diagnostic techniques in the head and neck. Dent Update. 2007, 34 (7): 410-2. 415-6, 419-20 passimPubMed
7.
Upile T, Jerjes W, Sterenborg HJ, El-Naggar AK, Sandison A, Witjes MJ, Biel MA, Bigio I, Wong BJ, Gillenwater A, MacRobert AJ, Robinson DJ, Betz CS, Stepp H, Bolotine L, McKenzie G, Mosse CA, Barr H, Chen Z, Berg K, D'Cruz AK, Stone N, Kendall C, Fisher S, Leunig A, Olivo M, Richards-Kortum R, Soo KC, Bagnato V, Choo-Smith LP, Svanberg K, Tan IB, Wilson BC, Wolfsen H, Yodh AG, Hopper C: Head & neck optical diagnostics: vision of the future of surgery. Head Neck Oncol. 2009, 1 (1): 25-10.1186/1758-3284-1-25.PubMedCentralCrossRefPubMed
8.
Jerjes W, Swinson B, Pickard D, Thomas GJ, Hopper C: Detection of cervical intranodal metastasis in oral cancer using elastic scattering spectroscopy. Oral Oncol. 2004, 40 (7): 673-8. 10.1016/j.oraloncology.2004.01.009.CrossRefPubMed
9.
Jerjes W, Swinson B, Johnson KS, Thomas GJ, Hopper C: Assessment of bony resection margins in oral cancer using elastic scattering spectroscopy: a study on archival material. Arch Oral Biol. 2005, 50 (3): 361-6. 10.1016/j.archoralbio.2004.08.003.CrossRefPubMed
10.
Sharwani A, Jerjes W, Salih V, Swinson B, Bigio IJ, El-Maaytah M, Hopper C: Assessment of oral premalignancy using elastic scattering spectroscopy. Oral Oncol. 2006, 42 (4): 343-9. 10.1016/j.oraloncology.2005.08.008.CrossRefPubMed
11.
Müller MG, Valdez TA, Georgakoudi I, Backman V, Fuentes C, Kabani S, Laver N, Wang Z, Boone CW, Dasari RR, Shapshay SM, Feld MS: Spectroscopic detection and evaluation of morphologic and biochemical changes in early human oral carcinoma. Cancer. 2003, 97 (7): 1681-92. 10.1002/cncr.11255.CrossRefPubMed
12.
Lovat LB, Johnson K, Mackenzie GD, Clark BR, Novelli MR, Davies S, O'Donovan M, Selvasekar C, Thorpe SM, Pickard D, Fitzgerald R, Fearn T, Bigio I, Bown SG: Elastic scattering spectroscopy accurately detects high grade dysplasia and cancer in Barrett's oesophagus. Gut. 2006, 55 (8): 1078-83.PubMedCentralCrossRefPubMed
13.
Amelink A, Sterenborg HJ, Bard MP, Burgers SA: In vivo measurement of the local optical properties of tissue by use of differential path-length spectroscopy. Opt Lett. 2004, 29 (10): 1087-9. 10.1364/OL.29.001087.CrossRefPubMed
14.
Amelink A, Kaspers OP, Sterenborg HJ, van der Wal JE, Roodenburg JL, Witjes MJ: Non-invasive measurement of the morphology and physiology of oral mucosa by use of optical spectroscopy. Oral Oncol. 2008, 44 (1): 65-71. 10.1016/j.oraloncology.2006.12.011.CrossRefPubMed
15.
Bard MP, Amelink A, Skurichina M, Noordhoek Hegt V, Duin RP, Sterenborg HJ, Hoogsteden HC, Aerts JG: Optical spectroscopy for the classification of malignant lesions of the bronchial tree. Chest. 2006, 129 (4): 995-1001. 10.1378/chest.129.4.995.CrossRefPubMed
16.
van Veen RL, Amelink A, Menke-Pluymers M, van der Pol C, Sterenborg HJ: Optical biopsy of breast tissue using differential path-length spectroscopy. Phys Med Biol. 2005, 50 (11): 2573-81. 10.1088/0031-9155/50/11/009.CrossRefPubMed
17.
Shan L, Hao Y, Wang S, Korotcov A, Zhang R, Wang T, Califano J, Gu X, Sridhar R, Bhujwalla ZM, Wang PC: Visualizing head and neck tumors in vivo using near-infrared fluorescent transferrin conjugate. Mol Imaging. 2008, 7 (1): 42-9.PubMed
18.
Bakker Schut TC, Witjes MJ, Sterenborg HJ, Speelman OC, Roodenburg JL, Marple ET, Bruining HA, Puppels GJ: In vivo detection of dysplastic tissue by Raman spectroscopy. Anal Chem. 2000, 72 (24): 6010-8. 10.1021/ac000780u.CrossRefPubMed
19.
de Veld DC, Bakker Schut TC, Skurichina M, Witjes MJ, Van der Wal JE, Roodenburg JL, Sterenborg HJ: Autofluorescence and Raman microspectroscopy of tissue sections of oral lesions. Lasers Med Sci. 2005, 19 (4): 203-9. 10.1007/s10103-004-0325-7.CrossRefPubMed
20.
Shetty G, Kendall C, Shepherd N, Stone N, Barr H: Raman spectroscopy: elucidation of biochemical changes in carcinogenesis of oesophagus. Br J Cancer. 2006, 94 (10): 1460-4. 10.1038/sj.bjc.6603102.PubMedCentralCrossRefPubMed
21.
Harris AT, Lungari A, Needham CJ, Smith SL, Lones MA, Fisher SE, Yang XB, Cooper N, Kirkham J, Smith DA, Martin-Hirsch DP, High AS: Potential for Raman spectroscopy to provide cancer screening using a peripheral blood sample. Head Neck Oncol. 2009, 1 (1): 34-10.1186/1758-3284-1-34.PubMedCentralCrossRefPubMed
22.
Harris AT, Garg M, Yang XB, Fisher SE, Kirkham J, Smith DA, Martin-Hirsch DP, High AS: Raman spectroscopy and advanced mathematical modelling in the discrimination of human thyroid cell lines. Head Neck Oncol. 2009, 1 (1): 38-10.1186/1758-3284-1-38.PubMedCentralCrossRefPubMed
23.
Das K, Stone N, Kendall C, Fowler C, Christie-Brown J: Raman spectroscopy of parathyroid tissue pathology. Lasers Med Sci. 2006, 21 (4): 192-7. 10.1007/s10103-006-0397-7.CrossRefPubMed
24.
Webb RH: Confocal optical microscopy. Rep Prog Phys. 1996, 59: 427-471. 10.1088/0034-4885/59/3/003.CrossRef
25.
Gareau DS, Li Y, Huang B, Eastman Z, Nehal KS, Rajadhyaksha M: Confocal mosaicing microscopy in Mohs skin excisions: feasibility of rapid surgical pathology. J Biomed Opt. 2008, 13 (5): 054001-10.1117/1.2981828.PubMedCentralCrossRefPubMed
26.
Webb RH, Hughes GW, Delori FC: Confocal scanning laser ophthalmoscope. Appl Optics. 1987, 26: 1492-1499. 10.1364/AO.26.001492.CrossRef
27.
Mustonen RK, McDonald MB, Srivannaboon S, Tan AL, Doubrava MW, Kim CK: Normal human corneal cell populations evaluated by in vivo scanning slit confocal microscopy. Cornea. 1998, 17: 485-492. 10.1097/00003226-199809000-00005.CrossRefPubMed
28.
Becker V, von Delius S, Bajbouj M, Karagianni A, Schmid RM, Meining A: Intravenous application of fluorescein for confocal laser scanning microscopy: evaluation of contrast dynamics and image quality with increasing injection-toimaging time. Gastrointest Endosc. 2008, 68: 319-323. 10.1016/j.gie.2008.01.033.CrossRefPubMed
29.
30.
Arens C, Reussner D, Woenkhaus J, Leunig A, Betz CS, Glanz H: Indirect fluorescence laryngoscopy in the diagnosis of precancerous and cancerous laryngeal lesions. Eur Arch Otorhinolaryngol. 2007, 264 (6): 621-6. 10.1007/s00405-007-0251-y.CrossRefPubMed
31.
Gillenwater A, Jacob R, Ganeshappa R, Kemp B, El-Naggar AK, Palmer JL, Clayman G, Mitchell MF, Richards-Kortum R: Noninvasive diagnosis of oral neoplasia based on fluorescence spectroscopy and native tissue autofluorescence. Arch Otolaryngol Head Neck Surg. 1998, 124 (11): 1251-8.CrossRefPubMed
32.
Heintzelman DL, Utzinger U, Fuchs H, Zuluaga A, Gossage K, Gillenwater AM, Jacob R, Kemp B, Richards-Kortum RR: Optimal excitation wavelengths for in vivo detection of oral neoplasia using fluorescence spectroscopy. Photochem Photobiol. 2000, 72 (1): 103-13. 10.1562/0031-8655(2000)072<0103:OEWFIV>2.0.CO;2.CrossRefPubMed
33.
Sharwani A, Jerjes W, Salih V, MacRobert AJ, El-Maaytah M, Khalil HS, Hopper C: Fluorescence spectroscopy combined with 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in detecting oral premalignancy. J Photochem Photobiol B. 2006, 83 (1): 27-33. 10.1016/j.jphotobiol.2005.11.007.CrossRefPubMed
34.
de Veld DC, Sterenborg HJ, Roodenburg JL, Witjes MJ: Effects of individual characteristics on healthy oral mucosa autofluorescence spectra. Oral Oncol. 2004, 40 (8): 815-23. 10.1016/j.oraloncology.2004.02.006.CrossRefPubMed
35.
Muldoon TJ, Thekkek N, Roblyer D, Maru D, Harpaz N, Potack J, Anandasabapathy S, Richards-Kortum R: Evaluation of quantitative image analysis criteria for the high-resolution microendoscopic detection of neoplasia in Barrett's esophagus J Biomed Opt. 2010, 15 (2):
36.
Huang D, Swanson EA, Lin CP, Schuman JS, Stinson WG, Chang W, Hee MR, Flotte T, Gregory K, Puliafito CA: Optical coherence tomography. Science. 1991, 254: 1178-1181. 10.1126/science.1957169.PubMedCentralCrossRefPubMed
37.
Vokes DE, Jackson R, Guo S, et al: Optical coherence tomography-enhanced microlaryngoscopy: preliminary report of a non-contact optical coherence tomography system integrated with a surgical microscope. Ann Otol Rhinol Laryngol. 2008, 117: 538-547.PubMedCentralCrossRefPubMed
38.
Rubinstein M, Fine EL, Sepehr A, Armstrong WB, Crumley RL, Kim JH, Chen Z, Wong BJ: Optical coherence tomography of the larynx using the Niris system. J Otolaryngol Head Neck Surg. 2010, 39 (2): 150-6.PubMedCentralPubMed
39.
Wong BJ, Jackson RP, Guo S, et al: In vivo optical coherence tomography of the human larynx: normative and benign pathology in 82 patients. Laryngoscope. 2005, 115: 1904-1911. 10.1097/01.MLG.0000181465.17744.BE.CrossRefPubMed
40.
Jerjes W, Upile T, Conn B, Hamdoon Z, Betz CS, McKenzie G, Radhi H, Vourvachis M, El Maaytah M, Sandison A, Jay A, Hopper C: In vitro examination of suspicious oral lesions using optical coherence tomography. Br J Oral Maxillofac Surg. 2010, 48 (1): 18-25. 10.1016/j.bjoms.2009.04.019.CrossRefPubMed
Metadata
Title
The future of medical diagnostics: review paper
Authors
Waseem K Jerjes
Tahwinder Upile
Brian J Wong
Christian S Betz
Henricus J Sterenborg
Max J Witjes
Kristian Berg
Robert van Veen
Merrill A Biel
Adel K El-Naggar
Charles A Mosse
Malini Olivo
Rebecca Richards-Kortum
Dominic J Robinson
Jennifer Rosen
Arjun G Yodh
Catherine Kendall
Justus F Ilgner
Arjen Amelink
Vanderlei Bagnato
Hugh Barr
Lina Bolotine
Irving Bigio
Zhongping Chen
Lin-Ping Choo-Smith
Anil K D'Cruz
Ann Gillenwater
Andreas Leunig
Alexander J MacRobert
Gordon McKenzie
Ann Sandison
Khee C Soo
Herbert Stepp
Nicholas Stone
Katarina Svanberg
I Bing Tan
Brian C Wilson
Herbert Wolfsen
Colin Hopper
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Head & Neck Oncology / Issue 1/2011
Electronic ISSN: 1758-3284
DOI
https://doi.org/10.1186/1758-3284-3-38

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