Published in:
Open Access
01-12-2021 | Research
The frequency of medical reversals in a cross-sectional analysis of high-impact oncology journals, 2009–2018
Authors:
Alyson Haslam, Jennifer Gill, Tyler Crain, Diana Herrera-Perez, Emerson Y. Chen, Talal Hilal, Myung S. Kim, Vinay Prasad
Published in:
BMC Cancer
|
Issue 1/2021
Login to get access
Abstract
Background
Identifying ineffective practices that have been used in oncology is important in reducing wasted resources and harm. We sought to examine the prevalence of practices that are being used but have been shown in RCTs to be ineffective (medical reversals) in published oncology studies.
Methods
We cross-sectionally analyzed studies published in three high-impact oncology medical journals (2009–2018). We abstracted data relating to the frequency and characterization of medical reversals.
Results
Of the 64 oncology reversals, medications (44%) represented the most common intervention type (39% were targeted). Fourteen (22%) were funded by pharmaceutical/industry only and 56% were funded by an organization other than pharmaceutical/industry. The median number of years that the practice had been in use prior to the reversal study was 9 years (range 1–50 years).
Conclusion
Here we show that oncology reversals most often involve the administration of medications, have been practiced for years, and are often identified through studies funded by non-industry organizations.