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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-02-2010 | Retinal Disorders

The flicker electroretinogram interocular amplitude ratio is a strong prognostic indicator of neovascularization in patients with central retinal vein occlusion

Authors: Hsi-Kung Kuo, Ming-Tse Kuo, Yung-Jen Chen, Pei-Chang Wu, Chih-Hsin Chen, Yi-Hao Chen

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 2/2010

Abstract

Background

To evaluate the prognostic value of interocular amplitude ratio of flicker electroretinogram (ERG) in determining the development of neovascularization in patients with central retinal vein occlusion (CRVO).

Methods

We retrospectively reviewed the data obtained from flicker ERG in 51 CRVO patients. Of these, 22 eyes which had enough follow-up to differentiate ischemic CRVO from nonischemic CRVO were included for data analysis. The flicker ERG was recorded at a 30 Hz frequency after dark adaptation, and ten sweeps were averaged.

Results

Eleven eyes were ischemic and 11 eyes were nonischemic. Three amplitude parameters had the potential to explain the type of CRVO. They were amplitude of lesion eye (p = 0.0001), interocular difference of amplitude (p < 0.0001), and interocular ratio of amplitude (p < 0.0001). Both an interocular amplitude difference of −23 μV and interocular amplitude ratio of 60% were very good cutoff points to differentiate ischemic from nonischemic CRVO. Receiver operating characteristic curve analysis revealed that each of the two cutoff values had a sensitivity and specificity of 100%.

Conclusions

Interocular comparison of amplitude is a good solution for avoiding the variability of ERG. An interocular amplitude ratio of flicker ERG of 60% is a succinct, useful parameter in clinical practices for differentiating ischemic from nonischemic CRVO.

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Title: The flicker electroretinogram interocular amplitude ratio is a strong prognostic indicator of neovascularization in patients with central retinal vein occlusion
Authors: Hsi-Kung Kuo
Ming-Tse Kuo
Yung-Jen Chen
Pei-Chang Wu
Chih-Hsin Chen
Yi-Hao Chen
Publication date: 01-02-2010
Publisher: Springer-Verlag
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 2/2010
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-009-1205-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The flicker electroretinogram interocular amplitude ratio is a strong prognostic indicator of neovascularization in patients with central retinal vein occlusion

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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