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Diabetology & Metabolic Syndrome
Published in: Diabetology & Metabolic Syndrome 1/2010

Open Access 01-12-2010 | Research

The eSS rat, a nonobese model of disordered glucose and lipid metabolism and fatty liver

Authors: Stella M Daniele, Silvana M Montenegro, María C Tarres, Juan C Picena, Stella M Martinez

Published in: Diabetology & Metabolic Syndrome | Issue 1/2010

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Abstract

Background

eSS is a rat model of type 2 diabetes characterized by fasting hyperglycemia, glucose intolerance, hyperinsulinemia and early hypertriglyceridemia. Diabetic symptoms worsen during the second year of life as insulin release decreases. In 12-month-old males a diffuse hepatic steatosis was detected. We report the disturbances of lipid metabolism of the model with regard to the diabetic syndrome.

Methods

The study was conducted in eight 12-month-old eSS male rats and seven age/weight matched eumetabolic Wistar rats fed with a complete commercial diet al libitum. Fasting plasmatic glucose, insulin, triglycerides, total cholesterol, low-density and high-density lipoprotein, and nonesterified fatty acids levels were measured. Very low density and intermediate-density lipoproteins were analyzed and hepatic lipase activity was determined.

Results

eSS rats developed hyperglycemia and hyperinsulinemia, indicating insulin resistance. Compared with controls, diabetic rats exhibited high plasmatic levels of NEFA, triglycerides (TG), total cholesterol (Chol) and LDL-Chol while high-density lipoprotein (HDL) cholesterol values were reduced. eSS rats also displayed TG-rich VLDL and IDL particles without changes in hepatic lipase activity.

Conclusion

The nonobese eSS rats develop a syndrome characterized by glucose and lipid disorders and hepatic steatosis that may provide new opportunities for studying the pathogenesis of human type 2 diabetes.
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Metadata
Title
The eSS rat, a nonobese model of disordered glucose and lipid metabolism and fatty liver
Authors
Stella M Daniele
Silvana M Montenegro
María C Tarres
Juan C Picena
Stella M Martinez
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Diabetology & Metabolic Syndrome / Issue 1/2010
Electronic ISSN: 1758-5996
DOI
https://doi.org/10.1186/1758-5996-2-15

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