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Published in: Maternal and Child Health Journal 7/2011

01-10-2011

The Epidemiology of Acute Poisonings in Women of Reproductive Age and During Pregnancy, California, 2000–2004

Authors: Candace K. McClure, Kenneth D. Katz, Thelma E. Patrick, Sheryl F. Kelsey, Harold B. Weiss

Published in: Maternal and Child Health Journal | Issue 7/2011

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Abstract

The aims of this study were to describe and compare the epidemiology of acute poisoning hospital discharges in women of reproductive age and during pregnancy (aged between 15 and 44) to include the incidence rate, risk factors, substances involved, rates of intentional versus unintentional poisonings, and in pregnant women, distribution over trimesters. Through a cohort study design, the California patient discharge dataset and linked vital statistics-patient discharge database were used to identify cases of acute poisoning hospital discharges from 2000 to 2004 among women of reproductive age and among pregnant women. Odds ratios (OR) were calculated to identify risk factors using logistic regression. Of 4,436,019 hospital discharges in women of reproductive age, 1% were for an acute poisoning (115.3/100,000 person-years). There were 2,285,540 deliveries and 833 hospital discharges for an acute poisoning during pregnancy (48.6/100,000 person-years). Pregnancy was associated with a lower risk of acute poisoning (OR = 0.89, P = 0.0007). Poisonings were greatest among young black women regardless of pregnancy status and among those with substance abuse or mental health problems. Analgesic and psychiatric medications were most commonly implicated. The majority of poisonings among women of reproductive age (69.6%) and among pregnant women (61.6%) were self-inflicted. Efforts to reduce acute poisonings among women of reproductive age should include education regarding the use of over-the-counter medications and interventions to reduce self-inflicted harm.
Literature
2.
go back to reference Schnitzer, P. G., & Runyan, C. W. (1995). Injuries to women in the United States: An Overview. Women and Health, 23(1), 9–27.CrossRef Schnitzer, P. G., & Runyan, C. W. (1995). Injuries to women in the United States: An Overview. Women and Health, 23(1), 9–27.CrossRef
3.
go back to reference Weiss, H. B. (1999). Pregnancy-associated injury hospitalizations in Pennsylvania, 1995. Annals of Emergency Medicine, 34, 626–636.PubMedCrossRef Weiss, H. B. (1999). Pregnancy-associated injury hospitalizations in Pennsylvania, 1995. Annals of Emergency Medicine, 34, 626–636.PubMedCrossRef
4.
go back to reference Gandhi, S. G., Gilbert, W. M., McElvy, S. S., et al. (2006). Maternal and neonatal outcomes after attempted suicide. Obstetrics and Gynecology, 107, 984–990.PubMedCrossRef Gandhi, S. G., Gilbert, W. M., McElvy, S. S., et al. (2006). Maternal and neonatal outcomes after attempted suicide. Obstetrics and Gynecology, 107, 984–990.PubMedCrossRef
5.
go back to reference Weiss, H. B., Lawrence, B., & Miller, T. (2002). Prevalence and risk of hospitalized pregnant occupants in car crashes. Annual Proceedings/Association for the Advancement of Automotive Medicine, 46, 355–362. Weiss, H. B., Lawrence, B., & Miller, T. (2002). Prevalence and risk of hospitalized pregnant occupants in car crashes. Annual Proceedings/Association for the Advancement of Automotive Medicine, 46, 355–362.
6.
go back to reference Schiff, M. A., & Holt, V. L. (2005). Pregnancy outcomes following hospitalization for motor vehicle crashes in Washington State from 1989 to 2001. American Journal of Epidemiology, 161(6), 503–510.PubMedCrossRef Schiff, M. A., & Holt, V. L. (2005). Pregnancy outcomes following hospitalization for motor vehicle crashes in Washington State from 1989 to 2001. American Journal of Epidemiology, 161(6), 503–510.PubMedCrossRef
7.
go back to reference Sirin, H., Weiss, H. B., Sauber-Schatz, E. K., et al. (2007). Seat belt use, counseling and motor-vehicle injury during pregnancy: Results from a multi-state population-based survey. Maternal and Child Health Journal, 11(5), 505–510.PubMedCrossRef Sirin, H., Weiss, H. B., Sauber-Schatz, E. K., et al. (2007). Seat belt use, counseling and motor-vehicle injury during pregnancy: Results from a multi-state population-based survey. Maternal and Child Health Journal, 11(5), 505–510.PubMedCrossRef
8.
go back to reference Hyde, L. K., Cook, L. J., Olson, L. M., et al. (2003). Effect of motor vehicle crashes on adverse fetal outcomes. Obstetrics and Gynecology, 102(2), 279–286.PubMedCrossRef Hyde, L. K., Cook, L. J., Olson, L. M., et al. (2003). Effect of motor vehicle crashes on adverse fetal outcomes. Obstetrics and Gynecology, 102(2), 279–286.PubMedCrossRef
9.
go back to reference Weiss, H. B., & Strotmeyer, S. (2002). Characteristics of pregnant women in motor vehicle crashes. Injury Prevention, 8(3), 207–210.PubMedCrossRef Weiss, H. B., & Strotmeyer, S. (2002). Characteristics of pregnant women in motor vehicle crashes. Injury Prevention, 8(3), 207–210.PubMedCrossRef
10.
go back to reference El Kady, D., Gilbert, W. M., Xing, G., et al. (2005). Maternal and neonatal outcomes of assaults during pregnancy. Obstetrics and Gynecology, 105(2), 357–363.PubMedCrossRef El Kady, D., Gilbert, W. M., Xing, G., et al. (2005). Maternal and neonatal outcomes of assaults during pregnancy. Obstetrics and Gynecology, 105(2), 357–363.PubMedCrossRef
11.
go back to reference Rachana, C., Suraiya, K., Hisham, A. S., et al. (2002). Prevalence and complications of physical violence during pregnancy. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 103(1), 26–29.PubMedCrossRef Rachana, C., Suraiya, K., Hisham, A. S., et al. (2002). Prevalence and complications of physical violence during pregnancy. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 103(1), 26–29.PubMedCrossRef
12.
go back to reference Weiss, H. B., Lawrence, B. A., & Miller, T. R. (2002). Pregnancy-associated assault hospitalizations. Obstetrics and Gynecology, 100(4), 773–780.PubMedCrossRef Weiss, H. B., Lawrence, B. A., & Miller, T. R. (2002). Pregnancy-associated assault hospitalizations. Obstetrics and Gynecology, 100(4), 773–780.PubMedCrossRef
13.
go back to reference Kamha, A. A., Al Omary, I. Y., Zalabany, H. A., et al. (2005). Organophosphate poisoning in pregnancy: A case report. Basic and Clinical Pharmacology and Toxicology, 96(5), 397–398.PubMedCrossRef Kamha, A. A., Al Omary, I. Y., Zalabany, H. A., et al. (2005). Organophosphate poisoning in pregnancy: A case report. Basic and Clinical Pharmacology and Toxicology, 96(5), 397–398.PubMedCrossRef
14.
go back to reference Hantson, P., Lambermont, J. Y., & Mahieu, P. (1997). Methanol poisoning during late pregnancy. Journal of Toxicology-Clinical Toxicology, 35(2), 187–191.PubMedCrossRef Hantson, P., Lambermont, J. Y., & Mahieu, P. (1997). Methanol poisoning during late pregnancy. Journal of Toxicology-Clinical Toxicology, 35(2), 187–191.PubMedCrossRef
15.
go back to reference Konje, J. C., Otolorin, E. O., Sotunmbi, P. T., et al. (1992). Insecticide poisoning in pregnancy. A case report. Journal of Reproductive Medicine, 37(12), 992–994.PubMed Konje, J. C., Otolorin, E. O., Sotunmbi, P. T., et al. (1992). Insecticide poisoning in pregnancy. A case report. Journal of Reproductive Medicine, 37(12), 992–994.PubMed
16.
go back to reference Lacoste, H., Goyert, G., Goldman, L. S., et al. (1992). Acute iron intoxication in pregnancy: Case report and review of the literature. Obstetrics and Gynecology, 80(3 Pt 2), 500–501.PubMed Lacoste, H., Goyert, G., Goldman, L. S., et al. (1992). Acute iron intoxication in pregnancy: Case report and review of the literature. Obstetrics and Gynecology, 80(3 Pt 2), 500–501.PubMed
17.
go back to reference Boyer, J. C., Hernandez, F., Estorc, J., et al. (2001). Management of maternal Amanita phalloides poisoning during the first trimester of pregnancy: A case report and review of the literature. Clinical Chemistry, 47(5), 971–974.PubMed Boyer, J. C., Hernandez, F., Estorc, J., et al. (2001). Management of maternal Amanita phalloides poisoning during the first trimester of pregnancy: A case report and review of the literature. Clinical Chemistry, 47(5), 971–974.PubMed
18.
go back to reference Zurawski, J. M., & Kelly, E. A. (1997). Pregnancy outcome after maternal poisoning with brodifacoum, a long-acting warfarin-like rodenticide. Obstetrics and Gynecology, 90(4 Pt 2), 672–674.PubMedCrossRef Zurawski, J. M., & Kelly, E. A. (1997). Pregnancy outcome after maternal poisoning with brodifacoum, a long-acting warfarin-like rodenticide. Obstetrics and Gynecology, 90(4 Pt 2), 672–674.PubMedCrossRef
19.
go back to reference Tran, T., Wax, J. R., Steinfeld, J. D., et al. (1998). Acute intentional iron overdose in pregnancy. Obstetrics and Gynecology, 92(4 Pt 2), 678–680.PubMedCrossRef Tran, T., Wax, J. R., Steinfeld, J. D., et al. (1998). Acute intentional iron overdose in pregnancy. Obstetrics and Gynecology, 92(4 Pt 2), 678–680.PubMedCrossRef
20.
go back to reference Hansen, L. M., Megerian, G., & Donnenfeld, A. E. (1997). Haloperidol overdose during pregnancy. Obstetrics and Gynecology, 90(4 Pt 2), 659–661.PubMedCrossRef Hansen, L. M., Megerian, G., & Donnenfeld, A. E. (1997). Haloperidol overdose during pregnancy. Obstetrics and Gynecology, 90(4 Pt 2), 659–661.PubMedCrossRef
21.
go back to reference Olenmark, M., Biber, B., Dottori, O., et al. (1987). Fatal iron intoxication in late pregnancy. Journal of Toxicology-Clinical Toxicology, 25(4), 347–359.PubMedCrossRef Olenmark, M., Biber, B., Dottori, O., et al. (1987). Fatal iron intoxication in late pregnancy. Journal of Toxicology-Clinical Toxicology, 25(4), 347–359.PubMedCrossRef
22.
go back to reference Mazurek, A., & Mazurek, J. (1975). Acute barbiturate poisoning in the 39th week of pregnancy. Case report. Anaesthesia, Resuscitation, & Intensive Therapy, 3(2), 193–196. Mazurek, A., & Mazurek, J. (1975). Acute barbiturate poisoning in the 39th week of pregnancy. Case report. Anaesthesia, Resuscitation, & Intensive Therapy, 3(2), 193–196.
23.
go back to reference Hoffman, R. S. (2000). Thallium poisoning during pregnancy: A case report and comprehensive literature review. Journal of Toxicology-Clinical Toxicology, 38(7), 767–775.PubMedCrossRef Hoffman, R. S. (2000). Thallium poisoning during pregnancy: A case report and comprehensive literature review. Journal of Toxicology-Clinical Toxicology, 38(7), 767–775.PubMedCrossRef
24.
go back to reference Wang, P. H., Yang, M. J., Lee, W. L., et al. (1997). Acetaminophen poisoning in late pregnancy. A case report. Journal of Reproductive Medicine, 42(6), 367–371.PubMed Wang, P. H., Yang, M. J., Lee, W. L., et al. (1997). Acetaminophen poisoning in late pregnancy. A case report. Journal of Reproductive Medicine, 42(6), 367–371.PubMed
25.
go back to reference McElhatton, P. R., Sullivan, F. M., & Volans, G. N. (1997). Paracetamol overdose in pregnancy. Analysis of the outcome of 300 cases referred to the teratology information service. Reproductive Toxicology, 11, 85–94.PubMedCrossRef McElhatton, P. R., Sullivan, F. M., & Volans, G. N. (1997). Paracetamol overdose in pregnancy. Analysis of the outcome of 300 cases referred to the teratology information service. Reproductive Toxicology, 11, 85–94.PubMedCrossRef
26.
go back to reference Gidai, J., Acs, N., Banhidy, F., et al. (2008). A study of the effects of large doses of medazepam used for self-poisoning in 10 pregnant women on fetal development. Toxicology and Industrial Health, 24, 61–68.PubMedCrossRef Gidai, J., Acs, N., Banhidy, F., et al. (2008). A study of the effects of large doses of medazepam used for self-poisoning in 10 pregnant women on fetal development. Toxicology and Industrial Health, 24, 61–68.PubMedCrossRef
27.
go back to reference Gidai, J., Acs, N., Banhidy, F., et al. (2008). A study of the teratogenic and fetotoxic effects of large doses of chlordiasepoxide used for self-poisoning by 35 pregnant women. Toxicology and Industrial Health, 24, 41–51.PubMedCrossRef Gidai, J., Acs, N., Banhidy, F., et al. (2008). A study of the teratogenic and fetotoxic effects of large doses of chlordiasepoxide used for self-poisoning by 35 pregnant women. Toxicology and Industrial Health, 24, 41–51.PubMedCrossRef
28.
go back to reference Czeizel, A. E., Timar, L., & Susanszky, E. (1999). Timing of suicide attempts by self-poisoning during pregnancy and pregnancy outcomes. Int J Gynaecol Obstet, 65, 39–45.PubMedCrossRef Czeizel, A. E., Timar, L., & Susanszky, E. (1999). Timing of suicide attempts by self-poisoning during pregnancy and pregnancy outcomes. Int J Gynaecol Obstet, 65, 39–45.PubMedCrossRef
29.
go back to reference Sein Anand, J., Chodorowski, Z., Ciechanowicz, R., et al. (2005). Acute suicidal self-poisonings during pregnancy. Przeglad Lekarski, 62(6), 434–435.PubMed Sein Anand, J., Chodorowski, Z., Ciechanowicz, R., et al. (2005). Acute suicidal self-poisonings during pregnancy. Przeglad Lekarski, 62(6), 434–435.PubMed
30.
go back to reference Czeizel, A. E., Tomcsik, M., & Timar, L. (1997). Teratologic evaluation of 178 infants born to mothers who attempted suicide by drugs during pregnancy. Obstetrics and Gynecology, 90(2), 195–201.PubMedCrossRef Czeizel, A. E., Tomcsik, M., & Timar, L. (1997). Teratologic evaluation of 178 infants born to mothers who attempted suicide by drugs during pregnancy. Obstetrics and Gynecology, 90(2), 195–201.PubMedCrossRef
31.
go back to reference Flint, C., Larsen, H., Nielsen, G. L., et al. (2002). Pregnancy outcome after suicide attempt by drug use: A Danish population-based study. Acta Obstetricia et Gynecologica Scandinavica, 81, 516–522.PubMedCrossRef Flint, C., Larsen, H., Nielsen, G. L., et al. (2002). Pregnancy outcome after suicide attempt by drug use: A Danish population-based study. Acta Obstetricia et Gynecologica Scandinavica, 81, 516–522.PubMedCrossRef
32.
go back to reference Herrchen, B., Gould, J. B., & Nesbitt, T. S. (1997). Vital statistics linked birth/infant death and hospital discharge record linkage for epidemiological studies. Computers and Biomedical Research, 30, 290–305.PubMedCrossRef Herrchen, B., Gould, J. B., & Nesbitt, T. S. (1997). Vital statistics linked birth/infant death and hospital discharge record linkage for epidemiological studies. Computers and Biomedical Research, 30, 290–305.PubMedCrossRef
33.
go back to reference Greenblatt, J. F., Dannenberg, A. L., & Johnson, C. J. (1997). Incidence of hospitalized injuries among pregnant women in Maryland, 1979–1990. American Journal of Preventive Medicine, 13, 374–379.PubMed Greenblatt, J. F., Dannenberg, A. L., & Johnson, C. J. (1997). Incidence of hospitalized injuries among pregnant women in Maryland, 1979–1990. American Journal of Preventive Medicine, 13, 374–379.PubMed
34.
go back to reference Dannenberg, A., Carter, D., Lawson, H., et al. (1995). Homicide and other injuries as causes of maternal death in New York City, 1987 through 1991. American Journal of Obstetrics and Gynecology, 172, 1557–1564.PubMedCrossRef Dannenberg, A., Carter, D., Lawson, H., et al. (1995). Homicide and other injuries as causes of maternal death in New York City, 1987 through 1991. American Journal of Obstetrics and Gynecology, 172, 1557–1564.PubMedCrossRef
35.
go back to reference Rosner, B. (1994). Fundamental of biostatistics (4th ed.). Belmont (CA): Duxbury Press. Rosner, B. (1994). Fundamental of biostatistics (4th ed.). Belmont (CA): Duxbury Press.
36.
go back to reference Forrester, M. B., & Stanley, S. K. (2004). Exposures and treatments among women of childbearing age and pregnant women reported to Texas poison centers. Veterinary and Human Toxicology, 46, 210–212.PubMed Forrester, M. B., & Stanley, S. K. (2004). Exposures and treatments among women of childbearing age and pregnant women reported to Texas poison centers. Veterinary and Human Toxicology, 46, 210–212.PubMed
37.
go back to reference Watson, W. A., Litovitz, T. L., Rodgers, G. C., et al. (2005). 2004 annual report of the American association of poison control centers toxic exposure surveillance system. American Journal of Emergency Medicine, 23, 589–666.PubMedCrossRef Watson, W. A., Litovitz, T. L., Rodgers, G. C., et al. (2005). 2004 annual report of the American association of poison control centers toxic exposure surveillance system. American Journal of Emergency Medicine, 23, 589–666.PubMedCrossRef
38.
go back to reference Rayburn, W., Aronow, R., DeLancey, B., et al. (1984). Drug overdose during pregnancy: An overview from a metropolitan poison control center. Obstetrics and Gynecology, 64, 611–614.PubMed Rayburn, W., Aronow, R., DeLancey, B., et al. (1984). Drug overdose during pregnancy: An overview from a metropolitan poison control center. Obstetrics and Gynecology, 64, 611–614.PubMed
Metadata
Title
The Epidemiology of Acute Poisonings in Women of Reproductive Age and During Pregnancy, California, 2000–2004
Authors
Candace K. McClure
Kenneth D. Katz
Thelma E. Patrick
Sheryl F. Kelsey
Harold B. Weiss
Publication date
01-10-2011
Publisher
Springer US
Published in
Maternal and Child Health Journal / Issue 7/2011
Print ISSN: 1092-7875
Electronic ISSN: 1573-6628
DOI
https://doi.org/10.1007/s10995-010-0571-1

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