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Open Access 01-12-2013 | Research article

The eNOS 894G/T gene polymorphism and its influence on early and long-term mortality after on-pump cardiac surgery

Authors: José Hinz, Daniel Schöndorf, Christian Bireta, Christina Lipke, Onnen Moerer, Ingo Bergmann, Christoph Herman Wiese, Ashham Mansur, Hanna Schotola, Anton Sabashnikov, Michael Quintel, Friedrich Albert Schoendube, Aron Frederik Popov

Published in: Journal of Cardiothoracic Surgery | Issue 1/2013

Abstract

Background

The eNOS 894G/T polymorphism (GG, GT, and TT) is associated with cardiovascular mortality and may influence cardiovascular diseases as a genetic risk factor. Moreover, this polymorphism has an impact on intraoperative hemodynamics during cardiac surgery with cardiopulmonary bypass (CPB). In this study, we analyzed the influence of this gene polymorphism on early clinical outcome in patients who underwent cardiac surgery with CPB. Also, we performed a 5-year follow-up, assessing the impact of this polymorphism on long-term mortality.

Method

500 patients who underwent cardiac surgery with CPB between 2006 and 2007 were included in this prospective single centre study. Genotyping for the eNOS gene polymorphism was performed by polymerase chain reaction amplification.

Results

Genotype distribution of 894G/T was: GG 50.2%; GT 42.2%; TT 7.8%. Cardiovascular risk factors were equally distributed between the different genotypes of the eNOS 894G/T polymorphism. No significant difference among the groups was shown regarding Euroscore, SAPS II and APACHE II. Perioperative characteristics were also not affected by the genotypes, except for the consumption of norepinephrine (p = 0.03) and amiodarone (p = 0.01) which was higher in the GT allele carrier. The early postoperative course was quite uniform across the genotypes, except for mean intensive care unit length of stay which was significantly prolonged in GT carriers (p = 0.001). The five-year follow-up was 100% complete and showed no significant differences regarding mortality between the groups.

Conclusion

Our results show that the eNOS 894G /T polymorphism is not associated with early and late clinical outcome after cardiac surgery. Thus, this polymorphism can actually not help to identify high risk groups in the heterogeneous population of individuals who undergo cardiac surgery with CPB.

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Title: The eNOS 894G/T gene polymorphism and its influence on early and long-term mortality after on-pump cardiac surgery
Authors: José Hinz
Daniel Schöndorf
Christian Bireta
Christina Lipke
Onnen Moerer
Ingo Bergmann
Christoph Herman Wiese
Ashham Mansur
Hanna Schotola
Anton Sabashnikov
Michael Quintel
Friedrich Albert Schoendube
Aron Frederik Popov
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: Journal of Cardiothoracic Surgery / Issue 1/2013
Electronic ISSN: 1749-8090
DOI: https://doi.org/10.1186/1749-8090-8-199

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The eNOS 894G/T gene polymorphism and its influence on early and long-term mortality after on-pump cardiac surgery

Abstract

Background

Method

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Method

Results

Conclusion

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