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Journal of Orthopaedic Surgery and Research

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Open Access 01-12-2018 | Research Article

The efficacy and safety of topical administration of tranexamic acid in spine surgery: a meta-analysis

Authors: Wei Luo, Ru-xin Sun, Han Jiang, Xin-long Ma

Published in: Journal of Orthopaedic Surgery and Research | Issue 1/2018

Abstract

Background

We conducted a meta-analysis from randomized controlled trials (RCTs) and non-RCTs to assess the efficacy and safety of tranexamic acid (TXA) in spine surgery.

Methods

Potentially relevant academic articles were identified from the Cochrane Library, MEDLINE (1966–2017.11), PubMed (1966–2017.11), Embase (1980–2017.11), and ScienceDirect (1985–2017.11). Secondary sources were identified from the references of the included literature. The pooled data were analyzed using RevMan 5.1.

Results

Three RCTs and one non-RCT met the inclusion criteria. There were significant differences in total blood loss (MD = − 267.53, 95% CI − 373.04 to − 106.02, P < 0.00001), drainage volume (MD = − 157.00, 95% CI − 191.17 to − 122.84, P < 0.00001), postoperative hemoglobin level (MD = 0.95, 95% CI 0.44 to 1.47, P = 0.0003), and length of hospital stay (MD = − 1.42, 95% CI − 1.92 to − 0.93, P < 0.00001). No significant differences were found regarding transfusion requirement, deep vein thrombosis (DVT), pulmonary embolism (PE), wound hematoma, and infection between the two groups.

Conclusions

The present meta-analysis indicated that the topical application of TXA in spinal surgery decreases the total blood loss and drainage volume and preserves higher postoperative hemoglobin level without increasing the risk of DVT infection, hematoma, DVT, and PE.

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Title: The efficacy and safety of topical administration of tranexamic acid in spine surgery: a meta-analysis
Authors: Wei Luo
Ru-xin Sun
Han Jiang
Xin-long Ma
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: Journal of Orthopaedic Surgery and Research / Issue 1/2018
Electronic ISSN: 1749-799X
DOI: https://doi.org/10.1186/s13018-018-0815-0

At a glance: The STEP trials

Springer Medicine

The efficacy and safety of topical administration of tranexamic acid in spine surgery: a meta-analysis

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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