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BMC Ophthalmology
Published in: BMC Ophthalmology 1/2018

Open Access 01-12-2018 | Research article

The efficacy and safety of Retcam in detecting neonatal retinal hemorrhages

Authors: Feng Chen, Dan Cheng, Jiandong Pan, Chongbin Huang, Xingxing Cai, Zhongxu Tian, Fan Lu, Lijun Shen

Published in: BMC Ophthalmology | Issue 1/2018

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Abstract

Background

To investigate the ability of characterizing neonatal retinal hemorrhage (RH) using RetCam in healthy newborns and the systemic effects during the procedure.

Methods

This prospective study enrolled 68 healthy newborns aged 2 to 4 days old. The RH was imaged and classified according to the location and numbers of hemorrhages. The heart rate (HR), respiration rate (RR), and oxygen saturation (OS) were recorded at 4 time points before (Phase 1, P1), during (P2 and P3) and after the examination (P4).

Results

The median exam time was 151 s. RH was present in 15 infants and 23 eyes. All 23 eyes had hemorrhage in Zone II. Grade II and III hemorrhages were present in 5 and 18 eyes, respectively. The HR increased to 168 beats per minute (bpm) in P3 and recovered to 122.5 bpm in P4. The RR increased to 38 bpm in P3 and recovered to 25 bpm in P4. The OS was reduced to 83% in P2 and recovered to 96% in P4.

Conclusions

RH in healthy newborns, mostly present in Zone II with grade II and III, can be characterized in detail by RetCam. Systemic effects during the process are mild and can be revolved spontaneously.
Literature
1.
Emerson MV, Pieramici DJ, Stoessel KM, Berreen JP, Gariano RF. Incidence and rate of disappearance of retinal hemorrhage in newborns. Ophthalmology. 2001;108(1):36–9.CrossRefPubMed
2.
Bergen R, Margolis S. Retinal hemorrhages in the newborn. Ann Ophthalmol. 1976;8(1):53–6.PubMed
3.
Besio R, Caballero C, Meerhoff E, Schwarcz R. Neonatal retinal hemorrhages and influence of perinatal factors. Am J Ophthalmol. 1979;87(1):74–6.CrossRefPubMed
4.
Van Noorden GK, Khodadoust A. Retinal hemorrhage in newborns and organic amblyopia. Arch Ophthalmol. 1973;89(2):91–3.CrossRefPubMed
5.
Laghmari M, Skiker H, Handor H, Mansouri B, Ouazzani Chahdi K, Lachkar R, Salhi Y, Cherkaoui O, Ouazzani Tnacheri B, Ibrahimy W, et al. Birth-related retinal hemorrhages in the newborn: incidence and relationship with maternal, obstetric and neonatal factors. Prospective study of 2,031 cases. Journal francais d'ophtalmologie. 2014;37(4):313–9.CrossRefPubMed
6.
Zhao Q, Zhang Y, Yang Y, Li Z, Lin Y, Liu R, Wei C, Ding X. Birth-related retinal hemorrhages in healthy full-term newborns and their relationship to maternal, obstetric, and neonatal risk factors. Graefes Arch Clin Exp Ophthalmol. 2015;253(7):1021–5.CrossRefPubMed
7.
Watts P, Maguire S, Kwok T, Talabani B, Mann M, Wiener J, Lawson Z, Kemp A. Newborn retinal hemorrhages: a systematic review. J AAPOS. 2013;17(1):70–8.CrossRefPubMed
8.
Callaway NF, Ludwig CA, Blumenkranz MS, Jones JM, Fredrick DR, Moshfeghi DM. Retinal and optic nerve hemorrhages in the newborn infant: one-year results of the newborn eye screen test study. Ophthalmology. 2016;123(5):1043–52.CrossRefPubMedPubMedCentral
9.
Suzuki Y, Awaya S. Long-term observation of infants with macular hemorrhage in the neonatal period. Jpn J Ophthalmol. 1998;42(2):124–8.CrossRefPubMed
10.
Zwaan J, Cardenas R, O'Connor PS. Long-term outcome of neonatal macular hemorrhage. J Pediatr Ophthalmol Strabismus. 1997;34(5):286–8.PubMed
11.
Li LH, Li N, Zhao JY, Fei P, Zhang GM, Mao JB, Rychwalski PJ. Findings of perinatal ocular examination performed on 3573, healthy full-term newborns. Br J Ophthalmol. 2013;97(5):588–91.CrossRefPubMedPubMedCentral
12.
Adams GG, Agrawal S, Sekhri R, Peters MJ, Pierce CM. Appearance and location of retinal haemorrhages in critically ill children. Br J Ophthalmol. 2013;97(9):1138–42.CrossRefPubMed
13.
Wu C, Petersen RA, VanderVeen DK. RetCam imaging for retinopathy of prematurity screening. J AAPOS. 2006;10(2):107–11.CrossRefPubMed
14.
Mukherjee AN, Watts P, Al-Madfai H, Manoj B, Roberts D. Impact of retinopathy of prematurity screening examination on cardiorespiratory indices: a comparison of indirect ophthalmoscopy and retcam imaging. Ophthalmology. 2006;113(9):1547–52.CrossRefPubMed
15.
16.
Rush R, Rush S, Nicolau J, Chapman K, Naqvi M. Systemic manifestations in response to mydriasis and physical examination during screening for retinopathy of prematurity. Retina. 2004;24(2):242–5.CrossRefPubMed
17.
Belda S, Pallas CR, De la Cruz J, Tejada P. Screening for retinopathy of prematurity: is it painful? Biol Neonate. 2004;86(3):195–200.CrossRefPubMed
18.
Mehta M, Adams GG, Bunce C, Xing W, Hill M. Pilot study of the systemic effects of three different screening methods used for retinopathy of prematurity. Early Hum Dev. 2005;81(4):355–60.CrossRefPubMed
19.
Kleberg A, Warren I, Norman E, Morelius E, Berg AC, Mat-Ali E, Holm K, Fielder A, Nelson N, Hellstrom-Westas L. Lower stress responses after newborn individualized developmental care and assessment program care during eye screening examinations for retinopathy of prematurity: a randomized study. Pediatrics. 2008;121(5):e1267–78.CrossRefPubMed
20.
Moral-Pumarega MT, Caserio-Carbonero S, De-La-Cruz-Bertolo J, Tejada-Palacios P, Lora-Pablos D, Pallas-Alonso CR. Pain and stress assessment after retinopathy of prematurity screening examination: indirect ophthalmoscopy versus digital retinal imaging. BMC Pediatr. 2012;12:132.CrossRefPubMedPubMedCentral
21.
Ju RH, Ke XY, Zhang JQ, Fu M. Outcomes of 957 preterm neonatal fundus examinations in a Guangzhou NICU through 2008 to 2011. Int J Ophthalmol. 2012;5(4):469–72.PubMedPubMedCentral
22.
Mulvihill AO, Jones P, Tandon A, Fleck BW, Minns RA. An inter-observer and intra-observer study of a classification of RetCam images of retinal haemorrhages in children. Br J Ophthalmol. 2011;95(1):99–104.CrossRefPubMed
23.
Studies of ocular complications of AIDS Foscarnet-Ganciclovir Cytomegalovirus Retinitis Trial: 1. Rationale, design, and methods. AIDS Clinical Trials Group (ACTG). Control Clin Trials 1992, 13(1):22–39.
24.
Hughes LA, May K, Talbot JF, Parsons MA. Incidence, distribution, and duration of birth-related retinal hemorrhages: a prospective study. J AAPOS. 2006;10(2):102–6.CrossRefPubMed
25.
26.
Clarke WN, Hodges E, Noel LP, Roberts D, Coneys M. The oculocardiac reflex during ophthalmoscopy in premature infants. Am J Ophthalmol. 1985;99(6):649–51.CrossRefPubMed
Metadata
Title
The efficacy and safety of Retcam in detecting neonatal retinal hemorrhages
Authors
Feng Chen
Dan Cheng
Jiandong Pan
Chongbin Huang
Xingxing Cai
Zhongxu Tian
Fan Lu
Lijun Shen
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Ophthalmology / Issue 1/2018
Electronic ISSN: 1471-2415
DOI
https://doi.org/10.1186/s12886-018-0887-y

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