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Allergy, Asthma & Clinical Immunology
Published in: Allergy, Asthma & Clinical Immunology 1/2014

Open Access 01-03-2014 | Meeting abstract

The effects of poly I:C stimulation of primary bronchial epithelial cells and TSLP secretion on CD34+ progenitor cell eosinophil and basophil differentiation

Authors: Ashley Yu, Claudia CK Hui, Judah A Denburg

Published in: Allergy, Asthma & Clinical Immunology | Special Issue 1/2014

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Excerpt

In asthmatic lungs, elevated levels of thymic stromal lymphopoetin (TSLP) are linked to eosinophilic inflammation and disease severity [1]. TSLP is involved in initiating a TH2 inflammatory response, through activation of T cells, and recently, CD34+ hemopoietic progenitor cells [2, 3]. However, the biological effects of epithelial-derived TSLP on human peripheral blood (PB) CD34+ progenitor eosinophil-basophil (Eo/B) lineage commitment have not been described. The aim of the current study is to examine the effects of primary bronchial epithelial cell-derived TSLP on CD34+ hemopoietic progenitor differentiation. …
Literature
1.
Shikotra A, Choy DF, Ohri CM, Doran E, Butler C, Hargadon B: Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma. J Allergy Clin Immunol. 2012, 129: 104-11. e1-9.)rintersCrossRefPubMed
2.
Wang WL, Li HY, Zhang MS, Gao PS, He SH, Zheng T, Zhu Z, Zhou LF: Thymic Stromal Lymphopoietin: A Promising Therapeutic Target for Allergic Diseases. Int Arch Allergy Immunol. 2013, 160: 18-26.CrossRefPubMed
3.
Kimura S, Pawankar R, Mori S, Nonaka M, Masuno S, Yagi T, Okubo K: Increased Expression and Role of Thymic Stromal Lymphopoietin in Nasal Polyposis. Allergy Asthma Immunol Res. 2011, 3: 186-PubMedCentralCrossRefPubMed
Metadata
Title
The effects of poly I:C stimulation of primary bronchial epithelial cells and TSLP secretion on CD34+ progenitor cell eosinophil and basophil differentiation
Authors
Ashley Yu
Claudia CK Hui
Judah A Denburg
Publication date
01-03-2014
Publisher
BioMed Central
DOI
https://doi.org/10.1186/1710-1492-10-S1-A47

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