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The Journal of Headache and Pain
Published in: The Journal of Headache and Pain 1/2013

Open Access 01-02-2013 | Poster presentation

The effects of botulinum toxin type A on the trigeminal TRPV1 containing neurons innervating the dura mater of rat

Authors: T Shimizu, M Shibata, H Toriumi, T Iwashita, M Funakubo, H Sato, T Kuroi, T Ebine, K Koizumi, N Suzuki

Published in: The Journal of Headache and Pain | Special Issue 1/2013

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Excerpt

Botulinum toxin type A (BTX-A) has been used for prophylactic treatment in chronic migraine. However, the precise mechanism of its action is obscure. We previously reported that the injection of BTX-A into the facial ophthalmic nerve region reduced the number of the TRPV1-immunoreactve (IR) neurons in the trigeminal ganglion (TG). The dura mater, known as an important site of headache generation, is densely innervated by trigeminal nociceptors. We have recently demonstrated the existence of TRPV1-IR nerve fibers in the dura mater that originate in TG. In this study, we explored the effect of BTX-A on the number of the TRPV1-IR TG neurons innervating the dura mater. …
Metadata
Title
The effects of botulinum toxin type A on the trigeminal TRPV1 containing neurons innervating the dura mater of rat
Authors
T Shimizu
M Shibata
H Toriumi
T Iwashita
M Funakubo
H Sato
T Kuroi
T Ebine
K Koizumi
N Suzuki
Publication date
01-02-2013
Publisher
Springer Milan
Published in
The Journal of Headache and Pain / Issue Special Issue 1/2013
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI
https://doi.org/10.1186/1129-2377-14-S1-P82

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