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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-05-2018 | Retinal Disorders

The effects of aging vitreous on contrast sensitivity function

Authors: Giancarlo A. Garcia, Matin Khoshnevis, Kenneth M. P. Yee, Justin H. Nguyen, Jeannie Nguyen-Cuu, Alfredo A. Sadun, J. Sebag

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 5/2018

Abstract

Purpose

Contrast sensitivity function (CSF) declines with age. When unassociated with cataracts, this is hypothesized to be due to macular ganglion cell complex (GCC) thinning. However, other studies found associations with increased vitreous echodensity and posterior vitreous detachment (PVD). We investigate the relationship between CSF, vitreous echodensity, PVD, and GCC thickness as related to age in the same subjects.

Methods

Age, CSF (Weber index: %W), vitreous echodensity (quantitative ultrasonography [QUS]), lens status (phakia or pseudophakia), best-corrected visual acuity (BCVA), and GCC thickness (SD-OCT) were evaluated in 57 eyes of 57 subjects with (n = 32, mean age = 62 years) and without (n = 25, mean age = 44 years) PVD (P < 0.001). A multivariate linear regression analysis was performed to assess the effects of independent variables on CSF.

Results

CSF was 51.2% worse in eyes with PVD (2.98 ± 0.31 %W) compared to no PVD (1.97 ± 0.24 %W; P < 0.001). QUS was 55.8% greater in eyes with PVD than those without (P < 0.001). Among all subjects, PVD status, vitreous echodensity, and age were the only independent variables demonstrating significant effects on CSF. Lens status, BCVA, and GCC thickness did not demonstrate association with CSF.

Conclusions

PVD, vitreous echodensity, and age are determinants of CSF. PVD and increased vitreous echodensity are each associated with diminished CSF, independent of age. Thus, in the absence of GCC thinning and cataracts, vitreous changes may be a cause of decreased CSF with age.

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Title: The effects of aging vitreous on contrast sensitivity function
Authors: Giancarlo A. Garcia
Matin Khoshnevis
Kenneth M. P. Yee
Justin H. Nguyen
Jeannie Nguyen-Cuu
Alfredo A. Sadun
J. Sebag
Publication date: 01-05-2018
Publisher: Springer Berlin Heidelberg
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 5/2018
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-018-3957-1

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Springer Medicine

The effects of aging vitreous on contrast sensitivity function

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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