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Journal of Orthopaedics and Traumatology

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Open Access 01-03-2015 | Original Article

The effect of tranexamic acid on artificial joint materials: a biomechanical study (the bioTRANX study)

Authors: Sattar Alshryda, James M. Mason, Praveen Sarda, T. Lou, Martin Stanley, Junjie Wu, Anthony Unsworth

Published in: Journal of Orthopaedics and Traumatology | Issue 1/2015

Abstract

Background

Tranexamic acid (TXA) has been successfully used to reduce bleeding in joint replacement. Recently local TXA has been advocated to reduce blood loss in total knee or hip replacement; however, this raised concerns about potential adverse effects of TXA upon the artificial joint replacement.

Materials and methods

In this biomechanical study we compared the effects of TXA and saline upon the following biomechanical properties of artificial joint materials—(1) tensile properties (ultimate strength, stiffness and Young’s modulus), (2) the wear rate using a multi-directional pin-on-plate machine, and (3) the surface topography of pins and plates before and after wear rate testing.

Results

There were no significant differences in tensile strength, wear rates or surface topography of either ultra-high-molecular-weight polyethylene pins or cobalt chromium molybdenum metal plates between specimens soaked in TXA and specimens soaked in saline.

Conclusion

Biomechanical testing shows that there are no biomechanical adverse affects on the properties of common artificial joint materials from using topical TXA.

Level of evidence

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Title: The effect of tranexamic acid on artificial joint materials: a biomechanical study (the bioTRANX study)
Authors: Sattar Alshryda
James M. Mason
Praveen Sarda
T. Lou
Martin Stanley
Junjie Wu
Anthony Unsworth
Publication date: 01-03-2015
Publisher: Springer International Publishing
Published in: Journal of Orthopaedics and Traumatology / Issue 1/2015
Print ISSN: 1590-9921
Electronic ISSN: 1590-9999
DOI: https://doi.org/10.1007/s10195-014-0312-0

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Springer Medicine

The effect of tranexamic acid on artificial joint materials: a biomechanical study (the bioTRANX study)

Abstract

Background

Materials and methods

Results

Conclusion

Level of evidence

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Materials and methods

Results

Conclusion

Level of evidence

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