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Nutrition & Metabolism
Published in: Nutrition & Metabolism 1/2014

Open Access 01-12-2014 | Research

The effect of the macrobiotic Ma-Pi 2 diet vs. the recommended diet in the management of type 2 diabetes: the randomized controlled MADIAB trial

Authors: Andreea Soare, Yeganeh M Khazrai, Rossella Del Toro, Elena Roncella, Lucia Fontana, Sara Fallucca, Silvia Angeletti, Valeria Formisano, Francesca Capata, Vladimir Ruiz, Carmen Porrata, Edlira Skrami, Rosaria Gesuita, Silvia Manfrini, Francesco Fallucca, Mario Pianesi, Paolo Pozzilli

Published in: Nutrition & Metabolism | Issue 1/2014

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Abstract

Background

Diet is an important component of type 2 diabetes therapy. Low adherence to current therapeutic diets points out to the need for alternative dietary approaches. This study evaluated the effect of a different dietary approach, the macrobiotic Ma-Pi 2 diet, and compared it with standard diets recommended for patients with type 2 diabetes.

Methods

A randomized, controlled, open-label, 21-day trial was undertaken in patients with type 2 diabetes comparing the Ma-Pi 2 diet with standard (control) diet recommended by professional societies for treatment of type 2 diabetes. Changes in fasting blood glucose (FBG) and post-prandial blood glucose (PPBG) were primary outcomes. HbA1c, insulin resistance (IR), lipid panel and anthropometrics were secondary outcomes.

Results

After correcting for age, gender, BMI at baseline, and physical activity, there was a significantly greater reduction in the primary outcomes FBG (95% CI: 1.79; 13.46) and PPBG (95% CI: 5.39; 31.44) in those patients receiving the Ma-Pi 2 diet compared with those receiving the control diet. Statistically significantly greater reductions in the secondary outcomes, HbA1c (95% CI: 1.28; 5.46), insulin resistance, total cholesterol, LDL cholesterol and LDL/HDL ratio, BMI, body weight, waist and hip circumference were also found in the Ma-Pi 2 diet group compared with the control diet group. The latter group had a significantly greater reduction of triglycerides compared with the Ma-Pi 2 diet group.

Conclusions

Intervention with a short-term Ma-Pi 2 diet resulted in significantly greater improvements in metabolic control in patients with type 2 diabetes compared with intervention with standard diets recommended for these patients.

Trial registration

Current Controlled Trials ISRCTN10467793.
Appendix
Available only for authorised users
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Metadata
Title
The effect of the macrobiotic Ma-Pi 2 diet vs. the recommended diet in the management of type 2 diabetes: the randomized controlled MADIAB trial
Authors
Andreea Soare
Yeganeh M Khazrai
Rossella Del Toro
Elena Roncella
Lucia Fontana
Sara Fallucca
Silvia Angeletti
Valeria Formisano
Francesca Capata
Vladimir Ruiz
Carmen Porrata
Edlira Skrami
Rosaria Gesuita
Silvia Manfrini
Francesco Fallucca
Mario Pianesi
Paolo Pozzilli
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Nutrition & Metabolism / Issue 1/2014
Electronic ISSN: 1743-7075
DOI
https://doi.org/10.1186/1743-7075-11-39

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